INT6322

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 46
Total Number 48
Disease Relevance 32.13
Pain Relevance 12.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) plasma membrane (Ceacam1)
Anatomy Link Frequency
spike 4
brain 3
B cells 3
plasma cell 1
spleens 1
Ceacam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 25 100.00 Very High Very High Very High
Inflammation 750 99.92 Very High Very High Very High
antagonist 19 99.80 Very High Very High Very High
spondylitis 9 99.72 Very High Very High Very High
opioid receptor 3 98.96 Very High Very High Very High
Morphine 25 97.96 Very High Very High Very High
Spinal cord 561 97.92 Very High Very High Very High
Demyelination 2091 97.76 Very High Very High Very High
analgesia 3 97.68 Very High Very High Very High
Analgesic 10 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 1469 100.00 Very High Very High Very High
Sprains And Strains 1450 100.00 Very High Very High Very High
Epstein-barr Virus 152 100.00 Very High Very High Very High
Adhesions 117 100.00 Very High Very High Very High
Meningitis 102 100.00 Very High Very High Very High
Demyelinating Disease 3893 99.98 Very High Very High Very High
INFLAMMATION 751 99.92 Very High Very High Very High
Stomach Cancer 58 99.84 Very High Very High Very High
Low Back Pain 10 99.72 Very High Very High Very High
Lymphatic System Cancer 109 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For convenience and clarity, in subsequent sections these recombinant strains were labeled in different names though they are the same but presented in different names, Penn 98-1 and Penn 98-2 are referred to as RSMHV2 (viruses expressing the MHV-2 spike in the MHV-A59 background) and wtR13 as RSA59 (viruses expressing the MHV-A59 spike in the MHV-A59 background).
Gene_expression (expressing) of MHV in spike associated with sprains and strains
1) Confidence 0.75 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 0.65 Pain Relevance 0.29
In addition, it was observed that higher doses of C-CAM were required to produce a shift down in the fentanyl dose-effect curve than were required to produce a shift down in the morphine dose-effect curve, which suggests that fentanyl is more efficacious than morphine.
Gene_expression (produce) of C-CAM associated with morphine
2) Confidence 0.67 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1326622 Disease Relevance 0 Pain Relevance 1.22
Antibodies against the HV2 loop of Opa I, AbHV2I linear, also demonstrated bactericidal activity against a homologous variant with a bactericidal50 concentration of 26 µg/mL.
Gene_expression (linear) of HV2
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.19 Pain Relevance 0
Taken together, these results suggest that C-CAM may be producing its antagonist action at opioid receptors through a nonequilibrium mechanism.
Gene_expression (producing) of C-CAM associated with antagonist and opioid receptor
4) Confidence 0.53 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1326622 Disease Relevance 0 Pain Relevance 1.04
After systemic administration, C-CAM produced a dose-dependent decrease in the Bmax values of both [3H]DAMGO ([D-Ala2, N-MePhe4, Gly5-ol][tyrosyl-3,5-3H]enkephalin) and [3H]naltrexone without affecting the Kd value of either ligand.
Neg (without) Gene_expression (produced) of C-CAM associated with enkephalin
5) Confidence 0.50 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965787 Disease Relevance 0 Pain Relevance 0.90
It was shown that CEACAM expression is elevated in many solid tumors [48,49].
Gene_expression (expression) of CEACAM associated with solid tumor
6) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.43 Pain Relevance 0.06
To our knowledge, the simultaneous overexpression of CEACAM-1, -5 and -6 proteins in pancreatic cancer cells has not been reported before.
Gene_expression (overexpression) of CEACAM associated with pancreatic cancer
7) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.49 Pain Relevance 0.11
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Gene_expression (overexpressed) of CEACAM associated with adhesions
8) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0
The pancreatic carcinoma cell markers (cytokeratins, CA 19-9) as well as the other overexpressed proteins identified in PaCa 5061 cell line (MUC 4, EGFR, CEACAM 1, -5, and -6) were analyzed by IHC in mouse primary tumor and corresponding metastasis and compared with the expression of this marker in the primary tumor of the patient.
Spec (analyzed) Gene_expression (overexpressed) of CEACAM associated with cancer, pancreatic cancer and metastasis
9) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.95 Pain Relevance 0
The top hits of overexpressed genes (fold change > 10) were Mucin 4 (MUC4) and some family members of the carcinoembryonic antigen-related adhesion molecules (CEACAM 1, CEACAM 5 and CEACAM 6).
Gene_expression (overexpressed) of CEACAM associated with adhesions
10) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.39 Pain Relevance 0.26
The top hits of overexpressed genes (fold change > 10) were Mucin 4 (MUC4) and some family members of the carcinoembryonic antigen-related adhesion molecules (CEACAM 1, CEACAM 5 and CEACAM 6).
Gene_expression (overexpressed) of CEACAM associated with adhesions
11) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.38 Pain Relevance 0.26
Specifically highly overexpressed genes (fold change > 10) were identified as EGFR, MUC4, CEACAM1, CEACAM5 and CEACAM6.
Gene_expression (overexpressed) of CEACAM1
12) Confidence 0.35 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2927995 Disease Relevance 0.66 Pain Relevance 0
Therefore, the elevated CEACAM 1, -5 and -6 and MUC4 levels in PaCa 5061 cells may well contribute to the high metastatic potential of these cells as well.
Gene_expression (levels) of CEACAM
13) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.31 Pain Relevance 0.05
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Gene_expression (overexpressed) of CEACAM associated with adhesions
14) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Gene_expression (overexpressed) of CEACAM associated with adhesions
15) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Gene_expression (overexpressed) of CEACAM associated with adhesions
16) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0
For convenience and clarity, in subsequent sections these recombinant strains were labeled in different names though they are the same but presented in different names, Penn 98-1 and Penn 98-2 are referred to as RSMHV2 (viruses expressing the MHV-2 spike in the MHV-A59 background) and wtR13 as RSA59 (viruses expressing the MHV-A59 spike in the MHV-A59 background).
Gene_expression (expressing) of MHV-2 in spike associated with sprains and strains
17) Confidence 0.34 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 0.64 Pain Relevance 0.29
For convenience and clarity, in subsequent sections these recombinant strains were labeled in different names though they are the same but presented in different names, Penn 98-1 and Penn 98-2 are referred to as RSMHV2 (viruses expressing the MHV-2 spike in the MHV-A59 background) and wtR13 as RSA59 (viruses expressing the MHV-A59 spike in the MHV-A59 background).
Gene_expression (expressing) of MHV-A59 in spike associated with sprains and strains
18) Confidence 0.34 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 0.57 Pain Relevance 0.26
Marked differences in the profiles of antagonism produced by beta-FNA and C-CAM were also apparent, as C-CAM, but not beta-FNA, produced insurmountable antagonism.
Neg (not) Gene_expression (produced) of C-CAM
19) Confidence 0.31 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649297 Disease Relevance 0 Pain Relevance 1.32
Marked differences in the profiles of antagonism produced by beta-FNA and C-CAM were also apparent, as C-CAM, but not beta-FNA, produced insurmountable antagonism.
Gene_expression (produced) of C-CAM
20) Confidence 0.31 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649297 Disease Relevance 0 Pain Relevance 1.27

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