INT6323

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Context Info
Confidence 0.70
First Reported 1981
Last Reported 2011
Negated 2
Speculated 15
Reported most in Abstract
Documents 213
Total Number 229
Disease Relevance 45.08
Pain Relevance 124.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 19
brain 12
neuronal 7
embryos 5
cerebrospinal fluid 3
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 5478 100.00 Very High Very High Very High
agonist 776 100.00 Very High Very High Very High
Neurotransmitter 618 100.00 Very High Very High Very High
Glutamate 525 100.00 Very High Very High Very High
GABA receptor 235 100.00 Very High Very High Very High
tetrodotoxin 156 100.00 Very High Very High Very High
Ventral tegmentum 50 100.00 Very High Very High Very High
Gabapentin 133 99.98 Very High Very High Very High
Morphine 97 99.98 Very High Very High Very High
Raphe 76 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 166 100.00 Very High Very High Very High
Epilepsy 137 100.00 Very High Very High Very High
Hypoxia 60 99.98 Very High Very High Very High
Respiratory Failure 38 99.88 Very High Very High Very High
Pain 91 99.76 Very High Very High Very High
Convulsion 464 99.64 Very High Very High Very High
Neuropathic Pain 107 99.40 Very High Very High Very High
Syndrome 72 99.24 Very High Very High Very High
Targeted Disruption 656 99.14 Very High Very High Very High
Congenital Anomalies 179 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that stimulation of both GABAA and GABAB receptor sites has an antinociceptive effect, but that the involvement of a GABAergic mechanism in stress-induced antinociception is unlikely.
Positive_regulation (stimulation) of GABAA associated with stress, antinociception, gabaergic and antinociceptive
1) Confidence 0.70 Published 1992 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1463371 Disease Relevance 0.70 Pain Relevance 1.04
It is concluded that GABAA receptor activation has a modulatory role in the naloxone sensitive analgesic effect of central type BZ-receptor agonists.
Positive_regulation (activation) of GABAA receptor associated with analgesic, agonist and narcan
2) Confidence 0.69 Published 1987 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 3035297 Disease Relevance 0 Pain Relevance 1.30
For example, at higher concentrations menthol directly activates GABAA receptors [42] and has an inhibitory effect on T-type Ca channel activity [43].
Positive_regulation (activates) of GABAA
3) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.25 Pain Relevance 0.04
However, in CeA neurons of HET mice, the previously characterized ethanol-induced increase of GABAA-IPSPs was abolished.
Positive_regulation (increase) of GABAA in neurons associated with amygdala
4) Confidence 0.67 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.15 Pain Relevance 0.37
A novel form of "tonic inhibition" has been described in the central nervous system (CNS) that is generated by the persistent activation of extrasynaptic gamma-aminobutyric acid type A receptors (GABAA-Rs).
Positive_regulation (activation) of GABAA in central nervous system associated with central nervous system
5) Confidence 0.67 Published 2007 Journal Alcohol Section Abstract Doc Link 17521848 Disease Relevance 0.17 Pain Relevance 0.60
These data indicate allopregnanolone increases and DHEAS decreases responsiveness of GnRH neurons to activation of GABAA receptors by differentially modulating current flow through GABAA receptor chloride channels.
Positive_regulation (activation) of GABAA in neurons
6) Confidence 0.66 Published 2003 Journal Endocrinology Section Abstract Doc Link 12960018 Disease Relevance 0 Pain Relevance 0.26
It is concluded that both GABAA and GABAB receptor activation reduced Straub tail induced by morphine.
Positive_regulation (activation) of GABAA in tail associated with morphine
7) Confidence 0.63 Published 2006 Journal Int. J. Neurosci. Section Abstract Doc Link 16861161 Disease Relevance 0 Pain Relevance 0.75
In addition, acetylcholine released after activation of GABAA receptors stimulates 5-HT release.
Positive_regulation (activation) of GABAA
8) Confidence 0.60 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2475352 Disease Relevance 0 Pain Relevance 0.32
Also, antinociception produced by i.c.v. heroin was inhibited by intrathecal administration of bicuculline and picrotoxin consistent with the concept that delta1 receptors in the brain mediated the antinociceptive response through descending neuronal pathways to the spinal cord to activate GABAA and GABAB receptors rather than spinal alpha2-adrenergic and serotonergic receptors activated originally by the mu agonist action in naive mice.
Positive_regulation (activate) of GABAA in neuronal associated with antinociception, agonist, antinociceptive, spinal cord and intrathecal
9) Confidence 0.59 Published 2000 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10806416 Disease Relevance 0 Pain Relevance 1.39
In contrast, in nicotine-treated mice, morphine increased GABA levels in the presence of nipecotic acid.
Positive_regulation (increased) of GABA associated with gaba, nicotine and morphine
10) Confidence 0.59 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18786163 Disease Relevance 0 Pain Relevance 1.58
Probably, the magnitude of the GABA level increase by vigabatrin is not sufficient to induce changes in the BDZ receptor (Maloteaux et al 1987).
Positive_regulation (increase) of GABA associated with gaba
11) Confidence 0.58 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.24 Pain Relevance 0.51
Our results indicate that activation of GABAA receptors at the supraspinal sites by i.c.v. injection of muscimol antagonizes antinociception induced by supraspinally administered mu-, epsilon-, delta-, and kappa-opioid receptor agonists.
Positive_regulation (activation) of GABAA associated with antinociception, agonist and kappa opioid receptor
12) Confidence 0.58 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9053732 Disease Relevance 0 Pain Relevance 1.47
Bicuculline concentration dependently decreased (1 microM) or increased (10, 50 microM) the release of 5-HT and 5-HIAA, indicating that endogenous GABA also activates stimulatory and inhibitory GABAA receptors.
Positive_regulation (activates) of GABAA associated with gaba
13) Confidence 0.52 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2475352 Disease Relevance 0 Pain Relevance 0.35
Chronic morphine administration augments benzodiazepine binding and GABAA receptor function.
Positive_regulation (augments) of GABAA receptor associated with morphine
14) Confidence 0.50 Published 1990 Journal Psychopharmacology (Berl.) Section Title Doc Link 1697078 Disease Relevance 0 Pain Relevance 0.86
These results indicate that chronic morphine but not naltrexone enhances benzodiazepine binding and GABAA receptor function, perhaps by an action at opioid receptors.
Positive_regulation (enhances) of GABAA receptor associated with opioid receptor and morphine
15) Confidence 0.50 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1697078 Disease Relevance 0 Pain Relevance 0.81
This effect was mediated via activation of GABAA receptors because when the cultures or slices were incubated in the presence of the GABAA antagonist bicuculline, dendritic growth was severely disrupted (mostly by reducing the number and length of primary dendrites), yielding dendritic arbors with much less complexity (Gascon et al., 2006).
Positive_regulation (activation) of GABAA in dendrites associated with antagonist
16) Confidence 0.50 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.31
At higher concentration, anesthetics directly activate GABAA receptors without the help of GABA [28].
Positive_regulation (activate) of GABAA associated with gaba
17) Confidence 0.49 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0 Pain Relevance 0.49
The failure of diazepam to suppress NK activity also suggests that increased chloride flux through diazepam-sensitive GABA-A receptors (which is caused by EtOH as well as diazepam) does not mediate NK suppression in this model.
Positive_regulation (increased) of GABA-A associated with gaba
18) Confidence 0.49 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.55
GABA-A involvement in the expression of PMP22 is confirmed by the finding that in cultured rat Schwann cells a specific GABA antagonist such as bicuculline completely abolishes the stimulatory effect exerted by 5?
Positive_regulation (involvement) of GABA-A in Schwann cells associated with gaba and antagonist
19) Confidence 0.49 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2873263 Disease Relevance 0.55 Pain Relevance 0.60
RESULTS: Like propofol, 4-iodopropofol enhanced GABA-induced currents in recombinant GABAA receptors, inhibited synaptic transmission in rat hippocampal slices, and inhibited sodium channel-mediated glutamate release from synaptosomes, but with reduced potency.
Positive_regulation (enhanced) of GABAA
20) Confidence 0.49 Published 2001 Journal Anesthesiology Section Body Doc Link 11465597 Disease Relevance 0 Pain Relevance 0

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