INT63238

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 10.86
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mt1) intracellular (Mt1) lysosome (Mt1)
Anatomy Link Frequency
PSCs 2
neuronal 2
astrocytes 2
MT2 1
liver 1
Mt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 27 98.70 Very High Very High Very High
Spinal cord 48 98.52 Very High Very High Very High
cytokine 66 97.68 Very High Very High Very High
peptic ulcer disease 1 97.52 Very High Very High Very High
agonist 30 92.28 High High
Inflammation 323 87.68 High High
fibrosis 6 71.28 Quite High
Chronic pancreatitis 3 68.32 Quite High
cva 2 62.96 Quite High
Inflammatory response 41 60.60 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 70 99.88 Very High Very High Very High
Adenocarcinoma 3 99.82 Very High Very High Very High
Gastritis 4 99.74 Very High Very High Very High
Stress 225 99.66 Very High Very High Very High
Motor Neuron Diseases 428 99.20 Very High Very High Very High
Pancreatitis 6 99.08 Very High Very High Very High
Toxicity 63 98.90 Very High Very High Very High
Disease 348 97.64 Very High Very High Very High
Ulcers 3 97.52 Very High Very High Very High
Primary Sclerosing Cholangitis 3 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, expression levels of metallothionein 1 and 2 mRNAs were different: no change of hepatic metallothionein 1 and 2 mRNA expression was induced by 100 mg/kg fenofibrate on Day 2 or 3, while 30 mg/kg Wy-14,643 administration increased expression of both genes by 1.8-fold on Day 3.
Gene_expression (expression) of metallothionein 1
1) Confidence 0.65 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11798191 Disease Relevance 0.06 Pain Relevance 0.22
However, expression levels of metallothionein 1 and 2 mRNAs were different: no change of hepatic metallothionein 1 and 2 mRNA expression was induced by 100 mg/kg fenofibrate on Day 2 or 3, while 30 mg/kg Wy-14,643 administration increased expression of both genes by 1.8-fold on Day 3.
Gene_expression (expression) of metallothionein 1
2) Confidence 0.58 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11798191 Disease Relevance 0.07 Pain Relevance 0.22
During our expression analysis of the motor cortex we identified several candidate genes, such as AQP1, CEBPD, SERPINA3, and the MT1 and MT2 family members, which are exclusively expressed in non-neuronal cells.
Gene_expression (expressed) of MT1 in neuronal
3) Confidence 0.48 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.79 Pain Relevance 0.09
Helicobacter-induced gastritis in mice not expressing metallothionein-I and II.
Gene_expression (expressing) of metallothionein-I associated with gastritis
4) Confidence 0.44 Published 2003 Journal Helicobacter Section Title Doc Link 14536000 Disease Relevance 0.49 Pain Relevance 0.10
During our expression analysis of the motor cortex we identified several candidate genes, such as AQP1, CEBPD, SERPINA3, and the MT1 and MT2 family members, which are exclusively expressed in non-neuronal cells.
Gene_expression (expression) of MT1 in neuronal
5) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.90 Pain Relevance 0.08
protein, MT-1 protein comprises many subtypes encoded by a set of MT-1 genes

(MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1H, and MT-1X), accounting for the

Gene_expression (genes) of MT-1G
6) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.22 Pain Relevance 0.04
protein, MT-1 protein comprises many subtypes encoded by a set of MT-1 genes

(MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1H, and MT-1X), accounting for the

Gene_expression (genes) of MT-1H
7) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.22 Pain Relevance 0.04
protein, MT-1 protein comprises many subtypes encoded by a set of MT-1 genes

(MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1H, and MT-1X), accounting for the

Gene_expression (genes) of MT-1F
8) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.22 Pain Relevance 0.04
protein, MT-1 protein comprises many subtypes encoded by a set of MT-1 genes

(MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1H, and MT-1X), accounting for the

Gene_expression (genes) of MT-1
9) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.21 Pain Relevance 0.04
protein, MT-1 protein comprises many subtypes encoded by a set of MT-1 genes

(MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1H, and MT-1X), accounting for the

Gene_expression (genes) of MT-1E
10) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.22 Pain Relevance 0.04
proteins are conventionally subdivided into 4 groups: MT-1, MT-2, MT-3, and
Gene_expression (subdivided) of MT-1 in MT-3
11) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.17 Pain Relevance 0.04
protein, MT-1 protein comprises many subtypes encoded by a set of MT-1 genes

(MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1H, and MT-1X), accounting for the

Gene_expression (genes) of MT-1B
12) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.22 Pain Relevance 0.04
protein, MT-1 protein comprises many subtypes encoded by a set of MT-1 genes

(MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1H, and MT-1X), accounting for the

Gene_expression (genes) of MT-1X
13) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.22 Pain Relevance 0.04
Importantly, endogenous MT1 and MT2 are undetectable in pure motoneuron cultures, which can be protected against oxidative stress by experimental MT1 overexpression [109], indicating the importance of metallothionein-mediated protection normally provided by astrocytes.


Gene_expression (overexpression) of MT1 in astrocytes associated with stress
14) Confidence 0.37 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.74 Pain Relevance 0.11
Metallothioneins of the MT1 and MT2 families are expressed in astrocytes, and are increased in spinal cord of ALS patients and in transgenic mutant-SOD1 mice, where their experimental reduction significantly reduces survival.
Gene_expression (expressed) of MT1 in astrocytes associated with targeted disruption, motor neuron diseases and spinal cord
15) Confidence 0.37 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.06 Pain Relevance 0.16
In normally developing mice exposed to increasing amounts of GnRH, there is a decline in MT1 expression in the pituitary gland, but in hpg mice which are not exposed to GnRH, this decline does not occur [22].
Gene_expression (expression) of MT1 in pituitary gland
16) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.07 Pain Relevance 0
A recent study of the expression of the pituitary melatonin receptor 1 (MT1) gene provides good evidence that the pituitary gland in hpg mice is arrested at an immature stage of development [22].
Gene_expression (expression) of MT1 in pituitary
17) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1249589 Disease Relevance 0.08 Pain Relevance 0
Because MT1 receptor expression in the SCN is decreased it is certainly possible that melatonin will be ineffective as a synchronizing agent although it is possible that a higher dose of melatonin or a more potent melatonin agonist such as ramelteon may be useful.
Gene_expression (expression) of MT1 associated with agonist
18) Confidence 0.33 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.74 Pain Relevance 0.05
It has been shown that with degeneration of the SCN, the master body clock, there is a decrease in the expression of MT1 receptors so that strength of melatonin as a synchronizing agent is reduced [126].
Gene_expression (expression) of MT1 in body
19) Confidence 0.33 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.65 Pain Relevance 0
We show that MT1, but not MT2, is occasionally expressed in PSCs in normal tissue, while in the diseased tissue MT1 is found at high rates in activated PSCs at all stages, and, additionally, in ductal epithelial cells.
Neg (not) Gene_expression (expressed) of MT1 in PSCs
20) Confidence 0.33 Published 2008 Journal Wien Med Wochenschr Section Abstract Doc Link 18998076 Disease Relevance 0.47 Pain Relevance 0.17

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