INT63268

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Context Info
Confidence 0.32
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.51
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncor1) DNA binding (Ncor1) cytoplasm (Ncor1)
Anatomy Link Frequency
plasma 1
liver 1
MCF-7 1
ventral 1
Ncor1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 28 96.00 Very High Very High Very High
Inflammation 2 82.08 Quite High
agonist 9 74.40 Quite High
Bile 2 22.40 Low Low
Pain 1 10.00 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5 95.60 Very High Very High Very High
Injury 12 92.56 High High
INFLAMMATION 2 82.08 Quite High
Repression 6 79.60 Quite High
Hyperalgesia 1 49.80 Quite Low
Obesity 3 25.76 Quite Low
Body Weight 20 5.00 Very Low Very Low Very Low
Abscess 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Adenocarcinoma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the bicuculline treated animals, SMRT decreased linearly with increasing plasma thiopentone concentrations (P < 0.001).
Negative_regulation (decreased) of SMRT in plasma
1) Confidence 0.32 Published 1996 Journal Can J Anaesth Section Body Doc Link 8723858 Disease Relevance 0 Pain Relevance 0
Accordingly, a significant down-regulation of NCoR-1-specific mRNA was found with a minimum at 6 h (Fig. 7a).
Negative_regulation (regulation) of NCoR-1-specific
2) Confidence 0.30 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0
N-CoR protein is reduced by acute administration of E2 in MCF-7 cells (Frasor et al. 2005) and by chronic hydroxytamoxifen in a mouse tumor model (Lavinsky et al. 1998).
Negative_regulation (reduced) of N-CoR protein in MCF-7 associated with cancer
3) Confidence 0.25 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0.18 Pain Relevance 0.04
SRC-1 protein levels were not significantly affected in prostate (Figure 6), but N-CoR protein levels were reduced after exposure to 0.7, 7 and 24 mg/kg 4-MBC (Figure 6), to 55.3, 64.5, and 76.1% in dorsolateral prostate, and 102.4, 85.8, and 75.8% in ventral prostate, respectively.


Negative_regulation (reduced) of N-CoR protein in ventral
4) Confidence 0.18 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0 Pain Relevance 0
Down-regulation of N-CoR may have implications for gene expression on a broad scale because N-CoR is recruited by many transcription factors, it also interacts with AR (Cheng S et al. 2002; Hodgson et al. 2005).
Negative_regulation (regulation) of N-CoR
5) Confidence 0.18 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0.16 Pain Relevance 0.03
1, DOR, and NCoR1 are down-regulated in the liver during APR, whereas the negative signaling factor TR?
Negative_regulation (regulated) of NCoR1 in liver
6) Confidence 0.13 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.17 Pain Relevance 0.27

General Comments

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