INT63270

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Context Info
Confidence 0.56
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 0.65
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncor1) DNA binding (Ncor1) cytoplasm (Ncor1)
Anatomy Link Frequency
myometrium 1
liver 1
hepatocytes 1
nucleus 1
endometrium 1
Ncor1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 70 87.76 High High
agonist 6 84.16 Quite High
Bile 5 33.36 Quite Low
Pain 1 10.00 Low Low
anesthesia 12 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 2 97.12 Very High Very High Very High
Cleidocranial Dysplasia 2 96.32 Very High Very High Very High
Benign Prostatic Hypertrophy 2 95.88 Very High Very High Very High
Repression 4 89.36 High High
Abscess 10 76.48 Quite High
Cancer 7 70.72 Quite High
Hyperalgesia 1 68.72 Quite High
Congenital Anomalies 2 8.52 Low Low
Injury 30 5.00 Very Low Very Low Very Low
Thyroid Disease 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the second protocol (20 rats), the effects of administration of saline, muscimol 0.5 mg.kg-1, or the competitive GABAA antagonist, bicuculline 0.25 mg.kg-1, upon the SMRT-reducing effects of a standardized thiopentone infusion were observed.
Gene_expression (reducing) of SMRT
1) Confidence 0.56 Published 1996 Journal Can J Anaesth Section Body Doc Link 8723858 Disease Relevance 0.07 Pain Relevance 0
T3 treatment of hepatocytes significantly induced early gene expression of DOR, NCoR-1, and TR?
Gene_expression (expression) of NCoR-1 in hepatocytes
2) Confidence 0.54 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0
Transcripts specific for DOR, nuclear receptor co-repressor 1 (NCoR-1), and TR?
Gene_expression (specific) of nuclear receptor co-repressor 1
3) Confidence 0.47 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2977073 Disease Relevance 0.08 Pain Relevance 0.04
1, NCoR-1, and the recently identified DOR/TP53INP2 are abundantly expressed and down-regulated in liver cells during APR.
Gene_expression (expressed) of NCoR-1 in liver
4) Confidence 0.42 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2977073 Disease Relevance 0.05 Pain Relevance 0.04
Reduced baseline AR levels in presence of reduced sensitivity to E2 and N-CoR levels indicate that the chronic condition probably resulted from a combination of multiple developmental and adult processes (Weihua et al. 2001; Woodham et al. 2003).
Gene_expression (levels) of N-CoR
5) Confidence 0.29 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0.16 Pain Relevance 0.04
The investigation revealed effects on classic toxicologic end points, expression of estrogen-regulated genes at mRNA and protein levels, estrogen sensitivity of target genes, and nuclear receptor co-repressor levels.
Gene_expression (expression) of nuclear receptor co-repressor
6) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0.29 Pain Relevance 0
Data are shown as fold-changes in mRNA expression of DOR, NCoR-1, TR?
Gene_expression (expression) of NCoR-1
7) Confidence 0.18 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0
Fold-change in mRNA expression of DOR, NCoR1, TR?
Gene_expression (expression) of NCoR1
8) Confidence 0.18 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0.03
They have reported that SMRT expression is found only sporadically both in the nucleus and in the cytoplasm of the glandular and stromal cells in the proliferative phase of the human endometrium.
Gene_expression (expression) of SMRT in nucleus
9) Confidence 0.10 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1931486 Disease Relevance 0 Pain Relevance 0
In another study, SMRT were also detected by multiprobe ribonuclease protection assay and real-time reverse transcriptase polymerase chain reaction, which showed that SMRT are expressed during the menstrual cycle in both endometrium and myometrium [33].
Gene_expression (expressed) of SMRT in myometrium
10) Confidence 0.10 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1931486 Disease Relevance 0 Pain Relevance 0
In another study, SMRT were also detected by multiprobe ribonuclease protection assay and real-time reverse transcriptase polymerase chain reaction, which showed that SMRT are expressed during the menstrual cycle in both endometrium and myometrium [33].
Gene_expression (expressed) of SMRT in endometrium
11) Confidence 0.03 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1931486 Disease Relevance 0 Pain Relevance 0

General Comments

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