INT63284

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Context Info
Confidence 0.66
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.34
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
brain 1
endothelium 1
microglial cells 1
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 11 100.00 Very High Very High Very High
Pain 4 98.52 Very High Very High Very High
cINOD 3 92.92 High High
cOX1 3 86.56 High High
COX2 7 81.72 Quite High
ischemia 3 77.52 Quite High
Inflammation 4 72.72 Quite High
Disease Link Frequency Relevance Heat
Pain 2 98.52 Very High Very High Very High
INFLAMMATION 7 95.04 Very High Very High Very High
Non-small-cell Lung Cancer 6 92.36 High High
Lung Cancer 2 88.32 High High
Cancer 2 86.16 High High
Acute-phase Reaction 2 77.72 Quite High
Cv Unclassified Under Development 3 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prescription of high doses of aspirin and selective cyclooxygenase-2 inhibitors is reported to increase cardiovascular events through suppression of the vasodilative prostanoid prostaglandin I(2) in endothelium.
Transcription (Prescription) of cyclooxygenase in endothelium associated with aspirin
1) Confidence 0.66 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19879866 Disease Relevance 0.24 Pain Relevance 0.34
In the peritoneal cells, the mRNA expression for the constitutive cyclooxygenase-1 (COX-1) was unchanged by PQ administration.
Transcription (expression) of cyclooxygenase-1
2) Confidence 0.51 Published 1998 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 9661217 Disease Relevance 0.07 Pain Relevance 0.04
Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide.
Transcription (Expression) of cyclooxygenase in brain
3) Confidence 0.20 Published 1996 Journal Brain Res. Section Title Doc Link 8724976 Disease Relevance 0.17 Pain Relevance 0.29
By RT-PCR, both cyclooxygenase (COX)-1 and COX-2 mRNAs are detected in NCI-H157 and H1264 cells.
Transcription (detected) of cyclooxygenase
4) Confidence 0.15 Published 1998 Journal Anticancer Res. Section Abstract Doc Link 9615719 Disease Relevance 0.76 Pain Relevance 0.31
METHODS: The effects of amygdalin extracted from Armeniacae semen on the LPS-stimulated mRNA expressions of cyclooxygenase (COX)-1, COX-2 and inducible nitric oxide synthase (iNOS) in the mouse BV2 microglial cells were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (expressions) of cyclooxygenase in microglial cells
5) Confidence 0.08 Published 2007 Journal Neurol. Res. Section Body Doc Link 17359643 Disease Relevance 0.10 Pain Relevance 0

General Comments

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