INT63328

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Context Info
Confidence 0.37
First Reported 1996
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 1.50
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
plasma 2
tail 2
Notch 1
Fgf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
analgesia 4 98.12 Very High Very High Very High
tail-flick 4 97.12 Very High Very High Very High
medulla 21 94.08 High High
Osteoarthritis 76 84.24 Quite High
Analgesic 12 75.00 Quite High
cytokine 21 73.52 Quite High
Central nervous system 3 68.12 Quite High
metalloproteinase 16 54.56 Quite High
Pain 12 52.52 Quite High
Arthritis 30 46.36 Quite Low
Disease Link Frequency Relevance Heat
Retinal Degeneration 29 91.04 High High
Aids-related Complex 10 85.28 High High
Osteoarthritis 78 84.24 Quite High
Injury 96 71.44 Quite High
Cancer 6 71.20 Quite High
Apoptosis 7 66.92 Quite High
INFLAMMATION 18 59.32 Quite High
Convulsion 1 56.96 Quite High
Pain 12 52.52 Quite High
Synovial Sarcoma 2 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraperitoneal (i.p.) injection of acidic fibroblast growth factor (aFGF) to Sprague-Dawley rats induced short-lasting analgesia as measured by tail-flick latency (TFL) test.
acidic fibroblast growth factor Binding (injection) of in tail associated with tail-flick and analgesia
1) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8728478 Disease Relevance 0 Pain Relevance 0.39
Intraperitoneal (i.p.) injection of acidic fibroblast growth factor (aFGF) to Sprague-Dawley rats induced short-lasting analgesia as measured by tail-flick latency (TFL) test.
aFGF Binding (injection) of in tail associated with tail-flick and analgesia
2) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8728478 Disease Relevance 0 Pain Relevance 0.39
On Western blot analysis, the FGF1 monoclonal antibody was recognized with the 15.8 kDa of recombinant human FGF1 (140 amino acid form) [5].
FGF1 Binding (recognized) of
3) Confidence 0.36 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0 Pain Relevance 0.05
To prepare the reagent for the immunoabsorption test, we used heparin-coated sepharose beads to remove the FGF1/FGF1 antibody complex, because FGF1 often reacts with heparan sulphate in tissues.
FGF1 Binding (complex) of
4) Confidence 0.36 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0 Pain Relevance 0.09
To prepare the reagent for the immunoabsorption test, we used heparin-coated sepharose beads to remove the FGF1/FGF1 antibody complex, because FGF1 often reacts with heparan sulphate in tissues.
FGF1 Binding (complex) of
5) Confidence 0.36 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0 Pain Relevance 0.09
The results of Fujimoto's study [19] demonstrated that the FGF receptor was expressed on the plasma membrane of regenerating axons and that exogenously applied FGF bound to the basal lamina, indicating that the binding of FGF and to its receptor facilitates axon regeneration.
FGF Binding (bound) of in plasma
6) Confidence 0.13 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0
The results of Fujimoto's study [19] demonstrated that the FGF receptor was expressed on the plasma membrane of regenerating axons and that exogenously applied FGF bound to the basal lamina, indicating that the binding of FGF and to its receptor facilitates axon regeneration.
FGF Binding (binding) of in plasma
7) Confidence 0.13 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0
Four different high-affinity receptors (FGFR1, FGFR2, FGFR3, and FGFR4) bind FGF ligands and display varying patterns of expression [14].
FGF Binding (bind) of
8) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.19 Pain Relevance 0.06
KM1334 recognized FGF8b and FGF8f specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family.
FGF Neg (little) Binding (binding) of
9) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.45 Pain Relevance 0.28
Among FGFs, in vivo and in vitro studies have revealed that basic FGF (FGF-2) has been recognized as an important neuro-survival factor.
basic FGF Binding (recognized) of
10) Confidence 0.03 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.79 Pain Relevance 0.03
Other growth factors, including Notch, FGF and BMP family members and their corresponding receptors, as well as the cell surface glycoprotein CD44 were also increased on the SuperArray, however, changes in their expression levels remain to be validated (Table S1).


FGF Binding (receptors) of in Notch
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.07 Pain Relevance 0.04

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