INT63333

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 30
Disease Relevance 30.09
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (RET) signal transduction (RET) plasma membrane (RET)
Anatomy Link Frequency
thyroid 4
lung 3
plasma 2
glial cell 2
germline 2
RET (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 218 99.74 Very High Very High Very High
Nerve growth factor 6 99.72 Very High Very High Very High
COX2 6 99.00 Very High Very High Very High
nociceptor 4 98.98 Very High Very High Very High
headache 9 98.52 Very High Very High Very High
backache 4 98.52 Very High Very High Very High
substance P 1 98.20 Very High Very High Very High
Calcitonin gene-related peptide 1 97.88 Very High Very High Very High
imagery 63 97.48 Very High Very High Very High
Neuropeptide 11 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 1335 100.00 Very High Very High Very High
Cancer 1245 100.00 Very High Very High Very High
Disease 652 100.00 Very High Very High Very High
Pheochromocytoma 131 100.00 Very High Very High Very High
Lung Cancer 47 99.96 Very High Very High Very High
Pancreatitis 5 99.96 Very High Very High Very High
Paraganglioma 96 99.92 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 77 99.88 Very High Very High Very High
Pancreatic Cancer 37 99.84 Very High Very High Very High
Multiple Endocrine Neoplasia 31 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high expression of RET (which, like EGFR, activates the RAS/ERK pathway) provides a plausible explanation of the failure of erlotinib to control proliferation of this tumor.
Gene_expression (expression) of RET associated with cancer
1) Confidence 0.76 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.76 Pain Relevance 0
The relationship between overexpression of glial cell-derived neurotrophic factor and its RET receptor with progression and prognosis of human pancreatic cancer.
Gene_expression (overexpression) of RET in glial cell associated with pancreatic cancer
2) Confidence 0.75 Published 2008 Journal J. Int. Med. Res. Section Title Doc Link 18652760 Disease Relevance 0.83 Pain Relevance 0.07
RET expression in pancreatic cancer tissues may be a useful prognostic marker.
Gene_expression (expression) of RET associated with pancreatic cancer
3) Confidence 0.75 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.96 Pain Relevance 0.08
We used immunohistochemical staining to assess protein over-expression of glial cell-derived neurotrophic factor (GDNF) and its RET receptor tyrosine kinase in patients with pancreatic cancer and benign pancreatic neoplasm, and assessed correlations with clinicopathological features and prognosis.
Gene_expression (expression) of RET in glial cell associated with pancreatic cancer
4) Confidence 0.75 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.55 Pain Relevance 0.05
Expression of neuropeptides calcitonin gene-related peptide and substance P, which specify peptidergic nociceptors, depends on nerve growth factor (NGF) signalling. ret expression indicative of non-peptidergic nociceptors is also promoted by the NGF-signalling pathway.
Gene_expression (expression) of ret in nociceptors associated with nerve growth factor, nociceptor, neuropeptide, substance p and calcitonin gene-related peptide
5) Confidence 0.75 Published 2009 Journal Cell Tissue Res. Section Abstract Doc Link 19387688 Disease Relevance 0.08 Pain Relevance 0.80
Prior to 2000, three different familial and syndromic diseases were known to result in PGL and/or PH: MEN-2 induced by germline inactivating mutations in the RET proto-oncogene; VHL disease due to mutations in the tumor suppressor gene VHL; and NF1 caused by mutations in the NF1 gene.
Gene_expression (disease) of RET in germline associated with cancer, paraganglioma, watson syndrome, disease and pheochromocytoma
6) Confidence 0.63 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.32 Pain Relevance 0.07
Mutational analysis for RET was negative.
Neg (negative) Gene_expression (negative) of RET
7) Confidence 0.60 Published 2003 Journal Pathologica Section Abstract Doc Link 14577203 Disease Relevance 1.07 Pain Relevance 0.10
[A case of multiple endocrine neoplasia type 2A (MEN2A) with a mutation in the RET gene].
Gene_expression (mutation) of RET gene associated with multiple endocrine neoplasia type 2a and multiple endocrine neoplasia
8) Confidence 0.59 Published 1999 Journal Hinyokika Kiyo Section Title Doc Link 10442282 Disease Relevance 0.79 Pain Relevance 0.15
Expression of RET was significantly related to lymphatic invasion, survival rate after tumour resection and degree of tumour cell differentiation.
Gene_expression (Expression) of RET associated with cancer
9) Confidence 0.58 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.95 Pain Relevance 0.10
In the lung tumor, RET was both highly amplified (hidden Markov model (HMM) level 4) and the most highly expressed known oncogene (34.5 fold change (FC) in lung relative to compendium; 123.2 FC in lung relative to blood) (Figure 2).
Gene_expression (expressed) of RET in lung associated with lung cancer
10) Confidence 0.57 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.68 Pain Relevance 0
Recently in a proteomics study of MTCs expressing RET germ-line mutations, Gorla and colleagues [25] demonstrated high-level expression of minimally phosphorylated EGFR in two separate MTC cell lines.
Gene_expression (expressing) of RET associated with thyroid neoplasm
11) Confidence 0.55 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.06 Pain Relevance 0
Prior to 2000, three different familial and syndromic diseases were known to result in PGL and/or PH: MEN-2 induced by germline inactivating mutations in the RET proto-oncogene; VHL disease due to mutations in the tumor suppressor gene VHL; and NF1 caused by mutations in the NF1 gene.
Gene_expression (/) of MEN-2 in germline associated with cancer, paraganglioma, watson syndrome, disease and pheochromocytoma
12) Confidence 0.55 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.42 Pain Relevance 0.08
The RET receptor tyrosine kinase (RTK)
Gene_expression (The) of RET receptor tyrosine kinase
13) Confidence 0.55 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.01 Pain Relevance 0.04
c-RET oncogene and its protein
Gene_expression (oncogene) of RET
14) Confidence 0.53 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 1.17 Pain Relevance 0.06
Two common oncogenes in papillary thyroid cancer, RET/PTC1 and RET/PTC 2, induce expression of COX2.
Gene_expression (/) of RET in thyroid associated with thyroid neoplasm and cox2
15) Confidence 0.53 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.19 Pain Relevance 0.10
However, in one study of 17 anaplastic cancers, no RET gene rearrangements were detected, providing no evidence for the evolution of papillary into anaplastic thyroid cancer [113].
Neg (no) Gene_expression (detected) of RET gene in thyroid associated with thyroid neoplasm and cancer
16) Confidence 0.53 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.50 Pain Relevance 0
The major genomic abnormalities detected in the lung tumor sample were the up-regulation of the MAPK pathways through RET over-expression and PTEN deletion.
Gene_expression (expression) of RET in lung associated with lung cancer and congenital anomalies
17) Confidence 0.51 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.72 Pain Relevance 0
The major genomic abnormalities detected in the lung tumor sample were the up-regulation of the MAPK pathways through RET over-expression and PTEN deletion.
Gene_expression (over) of RET in lung associated with lung cancer and congenital anomalies
18) Confidence 0.51 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.72 Pain Relevance 0
These rearrangements result in the production of chimeric proteins, named as RET/PTC and TRK.
Gene_expression (production) of RET associated with thyroid neoplasm
19) Confidence 0.47 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.31 Pain Relevance 0
Two common oncogenes in papillary thyroid cancer, RET/PTC1 and RET/PTC 2, induce expression of COX2.
Gene_expression (/) of PTC in thyroid associated with thyroid neoplasm and cox2
20) Confidence 0.46 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.24 Pain Relevance 0.10

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