INT63338

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 11
Speculated 9
Reported most in Abstract
Documents 42
Total Number 51
Disease Relevance 28.26
Pain Relevance 9.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
endothelial cell 20
alveolar macrophages 11
neutrophil 8
monocyte 4
endothelium 4
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 676 100.00 Very High Very High Very High
dexamethasone 90 100.00 Very High Very High Very High
lidocaine 21 100.00 Very High Very High Very High
substance P 20 100.00 Very High Very High Very High
Ultiva 2 100.00 Very High Very High Very High
Neuropeptide 12 99.98 Very High Very High Very High
cytokine 262 99.80 Very High Very High Very High
qutenza 6 99.74 Very High Very High Very High
cINOD 16 99.66 Very High Very High Very High
Nicotine 80 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 932 100.00 Very High Very High Very High
INFLAMMATION 763 100.00 Very High Very High Very High
Nicotine Addiction 1491 99.84 Very High Very High Very High
Atherosclerosis 111 99.64 Very High Very High Very High
Inflammatory Bowel Disease 72 99.32 Very High Very High Very High
Recurrence 4 99.18 Very High Very High Very High
Injury 41 99.16 Very High Very High Very High
Reperfusion Injury 3 99.12 Very High Very High Very High
Pain 3 98.68 Very High Very High Very High
Renal Cancer 5 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, dexamethasone did not influence rIFN-gamma-induced ICAM-1 expression.
Neg (not) Regulation (influence) of Gene_expression (expression) of ICAM-1 associated with dexamethasone
1) Confidence 0.62 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.23 Pain Relevance 0.26
Modulation of ICAM-1 expression in human alveolar macrophages in vitro.
Regulation (Modulation) of Gene_expression (expression) of ICAM-1 in alveolar macrophages
2) Confidence 0.62 Published 1996 Journal Eur. Respir. J. Section Title Doc Link 8730005 Disease Relevance 0.36 Pain Relevance 0.17
We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function.
Spec (examined) Regulation (effect) of Gene_expression (expression) of ICAM-1 in endothelial cell associated with adhesions and substance p
3) Confidence 0.61 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.20 Pain Relevance 0.36
Whereas dexamethasone did not influence ICAM-1 expression in AM, it downregulated TNF alpha production at least in part at the transcriptional level.
Neg (not) Regulation (influence) of Gene_expression (expression) of ICAM-1 associated with dexamethasone
4) Confidence 0.61 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8906220 Disease Relevance 0.53 Pain Relevance 0.35
Furthermore, we have studied the effects of the glucocorticoid dexamethasone, the key drug for the treatment of allograft rejection, on the expression of ICAM-1 and TNF alpha induced in vitro in AM, at the levels of protein production and of transcription.
Regulation (effects) of Gene_expression (expression) of ICAM-1 associated with dexamethasone
5) Confidence 0.61 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8906220 Disease Relevance 0.55 Pain Relevance 0.27
In studies of the pulmonary endothelium, there is some evidence that ICAM-1 expression by bronchial vessels may not be affected by smoking [95].
Regulation (affected) of Gene_expression (expression) of ICAM-1 in endothelium associated with nicotine addiction
6) Confidence 0.60 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.24 Pain Relevance 0.04
In studies of the pulmonary endothelium, there is some evidence that ICAM-1 expression by bronchial vessels may not be affected by smoking [95].
Neg (not) Regulation (affected) of Gene_expression (expression) of ICAM-1 in endothelium associated with nicotine addiction
7) Confidence 0.60 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.24 Pain Relevance 0.04
To investigate the effects of pancreatic proteases on ICAM-1 expression and their role in the early process of leukocyte migration, human umbilical vein endothelial cells (HUVECs) were incubated with serum subjected to limited trypsin digestion and Wistar rats were injected with trypsin.
Spec (investigate) Regulation (effects) of Gene_expression (expression) of ICAM-1 in endothelial cells
8) Confidence 0.60 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.27 Pain Relevance 0
Effects of remifentanil on neutrophil adhesion, transmigration, and intercellular adhesion molecule expression.
Regulation (Effects) of Gene_expression (expression) of intercellular adhesion molecule in neutrophil associated with ultiva and adhesions
9) Confidence 0.59 Published 2000 Journal Acta Anaesthesiol Scand Section Title Doc Link 11065203 Disease Relevance 0.39 Pain Relevance 0.34
B1 p50 oligonucleotides did not affect the expression of ICAM-1 in HUVEC, no matter whether added individually or simultaneously.


Neg (not) Spec (whether) Regulation (affect) of Spec (whether) Gene_expression (expression) of ICAM-1
10) Confidence 0.56 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Modulation of intercellular adhesion molecule-1 (ICAM-1) expression may be a basic mechanism by which alveolar macrophages (AMs) regulate the inflammatory process in the lung in response to local stimuli.
Regulation (Modulation) of Gene_expression (expression) of adhesion molecule-1 in alveolar macrophages associated with inflammation and adhesions
11) Confidence 0.54 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.36 Pain Relevance 0.16
Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function.
Regulation (regulation) of Gene_expression (expression) of ICAM-1 in endothelial cell associated with neuropeptide
12) Confidence 0.53 Published 1998 Journal Am. J. Physiol. Section Title Doc Link 9843720 Disease Relevance 0.19 Pain Relevance 0.63
As a model for studying the anti-inflammatory activity of drugs on human AMs, we investigated the effects of fusafungine, an antibiotic for local use by aerosol with anti-inflammatory properties, and that of the glucocorticoid dexamethasone, on ICAM-1 expression induced in vitro by recombinant interferon-gamma (rIFN-gamma).
Spec (investigated) Regulation (effects) of Gene_expression (expression) of ICAM-1 in AMs associated with inflammation and dexamethasone
13) Confidence 0.45 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.38 Pain Relevance 0.20
Modulation of intercellular adhesion molecule-1 (ICAM-1) expression may be a basic mechanism by which alveolar macrophages (AMs) regulate the inflammatory process in the lung in response to local stimuli.
Regulation (Modulation) of Gene_expression (expression) of ICAM-1 in alveolar macrophages associated with inflammation and adhesions
14) Confidence 0.45 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.36 Pain Relevance 0.16
We examined the direct effect of SP on human dermal microvascular endothelial cell (HDMEC) intercellular adhesion molecule 1 (ICAM-1) expression and function.
Spec (examined) Regulation (effect) of Gene_expression (expression) of intercellular adhesion molecule 1 in endothelial cell associated with adhesions and substance p
15) Confidence 0.45 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.20 Pain Relevance 0.36
We investigated the effects of lidocaine on activated human umbilical vein endothelial cell (HUVEC) interleukin (IL)-1beta, IL-6, and IL-8 concentrations and intercellular adhesion molecule-1 (ICAM-1) expression.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of ICAM-1 in endothelial cell associated with lidocaine and adhesions
16) Confidence 0.44 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.46 Pain Relevance 0.42
We investigated the effects of lidocaine on activated human umbilical vein endothelial cell (HUVEC) interleukin (IL)-1beta, IL-6, and IL-8 concentrations and intercellular adhesion molecule-1 (ICAM-1) expression.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of intercellular adhesion molecule-1 in endothelial cell associated with lidocaine and adhesions
17) Confidence 0.44 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.46 Pain Relevance 0.42
Activated endothelial IL-1beta, IL-6, and IL-8 concentrations and ICAM-1 expression are attenuated only by lidocaine at concentrations larger than clinically relevant concentrations.
Regulation (attenuated) of Gene_expression (expression) of ICAM-1 associated with lidocaine
18) Confidence 0.44 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.25 Pain Relevance 0.52
The reduced angiogenic response and compromised endothelial ICAM-1 expression profiles in the gingival tissues of smokers may help explain this initially surprising observation.
Regulation (response) of Gene_expression (expression) of ICAM-1 associated with nicotine addiction
19) Confidence 0.44 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.68 Pain Relevance 0.06
Adams et al. [102] were able to show upregulation of ICAM-1 (but not VCAM-1 or E-selectin) expression on HUVECs exposed to smokers' serum, and to confirm increased monocyte-endothelium adhesion in smokers selected to exhibit no other major risk factor for vascular disease.
Regulation (upregulation) of Gene_expression (expression) of ICAM-1 in monocyte associated with nicotine addiction, increased venous pressure under development and adhesions
20) Confidence 0.44 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.85 Pain Relevance 0.18

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