INT63339

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.92
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
HCEC 1
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 6 98.98 Very High Very High Very High
ischemia 7 98.74 Very High Very High Very High
dexamethasone 4 96.16 Very High Very High Very High
chemokine 11 95.88 Very High Very High Very High
Inflammation 75 84.72 Quite High
cINOD 2 81.60 Quite High
Neuropeptide 4 76.68 Quite High
qutenza 2 75.92 Quite High
Inflammatory response 11 75.40 Quite High
cytokine 4 52.96 Quite High
Disease Link Frequency Relevance Heat
Polymyalgia Rheumatica 38 99.96 Very High Very High Very High
Giant Cell Arteritis 39 99.64 Very High Very High Very High
Hypoxia 1 98.92 Very High Very High Very High
Cv Unclassified Under Development 7 98.74 Very High Very High Very High
Adhesions 194 96.56 Very High Very High Very High
Bladder Cancer 4 96.24 Very High Very High Very High
Injury 1 88.88 High High
Pressure And Volume Under Development 1 86.88 High High
Encephalitis 1 84.72 Quite High
INFLAMMATION 89 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of ICAM-1 downregulation was mainly post-transcriptional, but also partly transcriptional.
Transcription (post-transcriptional) of ICAM-1
1) Confidence 0.69 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.25 Pain Relevance 0.26
ICAM-1 biallelic polymorphisms
Transcription (polymorphisms) of ICAM-1
2) Confidence 0.54 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.69 Pain Relevance 0.12
The addition of SP to HDMEC resulted in a rapid increase in cellular ICAM-1 mRNA levels, followed by a fivefold increase in ICAM-1 cell surface expression.
Transcription (levels) of ICAM-1 associated with substance p
3) Confidence 0.53 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.16 Pain Relevance 0.50
Transcriptional regulation of ICAM-1 is particularly complex, with unusual post-transcriptional control mechanisms described [50,51,66].
Transcription (Transcriptional) of ICAM-1
4) Confidence 0.52 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.43 Pain Relevance 0.03
Transcriptional regulation of ICAM-1 is particularly complex, with unusual post-transcriptional control mechanisms described [50,51,66].
Transcription (Transcriptional) of ICAM-1
5) Confidence 0.52 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.43 Pain Relevance 0.03
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Transcription (express) of ICAM-1 in HCEC associated with chemokine, hypoxia and ischemia
6) Confidence 0.47 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 0.97 Pain Relevance 0.43

General Comments

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