INT63340

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 2
Speculated 7
Reported most in Body
Documents 109
Total Number 118
Disease Relevance 90.82
Pain Relevance 20.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
endothelial cells 30
leukocyte 16
neutrophil 15
macrophages 10
platelets 6
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1938 100.00 Very High Very High Very High
cytokine 902 100.00 Very High Very High Very High
chemokine 203 100.00 Very High Very High Very High
ischemia 71 99.98 Very High Very High Very High
lidocaine 22 99.92 Very High Very High Very High
substance P 50 99.50 Very High Very High Very High
Neuropeptide 20 99.28 Very High Very High Very High
cINOD 52 99.08 Very High Very High Very High
rheumatoid arthritis 270 99.04 Very High Very High Very High
Inflammatory stimuli 14 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2275 100.00 Very High Very High Very High
Adhesions 2024 100.00 Very High Very High Very High
Atherosclerosis 254 100.00 Very High Very High Very High
Cv Unclassified Under Development 62 99.98 Very High Very High Very High
Respiratory Syncytial Virus 4 99.96 Very High Very High Very High
Nicotine Addiction 2864 99.90 Very High Very High Very High
Cholesteatoma 144 99.72 Very High Very High Very High
Pressure And Volume Under Development 81 99.66 Very High Very High Very High
Thyroid Neoplasm 23 99.64 Very High Very High Very High
Cancer 872 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Culture for 24 h with rIFN-gamma resulted in a significant increase in ICAM-1 protein expression (82% of cells were strongly positive).
Positive_regulation (increase) of Gene_expression (expression) of ICAM-1
1) Confidence 0.70 Published 1996 Journal Eur. Respir. J. Section Abstract Doc Link 8730005 Disease Relevance 0.29 Pain Relevance 0.25
The results indicate that ICAM-1 targeted immunoliposomes may be used as carriers for the intracellular delivery of anti-inflammatory drugs to sites of inflammation characterised by an increased expression of ICAM-1.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1 associated with inflammation and cinod
2) Confidence 0.70 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.34 Pain Relevance 0.15
These results indicate that neuropeptides such as SP are capable of directly activating HDMEC to express increased levels of functional ICAM-1 and further support the role of the cutaneous neurological system in modulating inflammatory processes in the skin.
Positive_regulation (activating) of Gene_expression (express) of ICAM-1 in skin associated with inflammation, neuropeptide and substance p
3) Confidence 0.69 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.22 Pain Relevance 0.51
Conversely, expression of the adhesion molecule ICAM-1 was significantly increased in livers of brain-dead organ donors.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1 in livers
4) Confidence 0.68 Published 2006 Journal Neuroimmunomodulation Section Body Doc Link 16864968 Disease Relevance 0.14 Pain Relevance 0
RESULTS: Exposure to hypoxia-reoxygenation increased neutrophil CD11b (94.33+/-40.65 vs. 34.32+/-6.83 mean channel fluorescence (MCF), P = 0.02), CD18 (109.84+/-35.44 vs. 59.05+/-6.71 MCF, P = 0.03) and endothelial ICAM-1 (146.62+/-16.78 vs. 47.29+/-9.85 MCF, P < 0.001) expression compared to normoxia.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1 in neutrophil
5) Confidence 0.68 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0.22 Pain Relevance 0
In contrast to these reports, Haller et al. (22) reported that ICAM-1 expression was increased in serum from preeclamptic patients but VCAM-1 expression was not.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1
6) Confidence 0.68 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.63 Pain Relevance 0.07
ICAM-1 expression is increased in the gingival vasculature during episodes of experimental gingivitis, -induced on cessation of normal oral hygiene procedures-coincident with peak measurements of IL-1 in the gingival crevicular fluid (GCF; a serum-derived fluid that exudes from the gingival sulcus) [117].
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1 in sulcus associated with mouth disease
7) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.89 Pain Relevance 0.16
As mentioned earlier, constituents of tobacco smoke can induce ICAM-1 expression on endothelial cells [33,80,93,102].
Positive_regulation (induce) of Gene_expression (expression) of ICAM-1 in endothelial cells associated with nicotine addiction
8) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.20 Pain Relevance 0.12
As mentioned earlier, constituents of tobacco smoke can induce ICAM-1 expression on endothelial cells [33,80,93,102].
Positive_regulation (induce) of Gene_expression (expression) of ICAM-1 in endothelial cells associated with nicotine addiction
9) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.20 Pain Relevance 0.12
ICAM-1 expression is increased in the gingival vasculature during episodes of experimental gingivitis, -induced on cessation of normal oral hygiene procedures-coincident with peak measurements of IL-1 in the gingival crevicular fluid (GCF; a serum-derived fluid that exudes from the gingival sulcus) [117].
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1 in sulcus associated with mouth disease
10) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.89 Pain Relevance 0.16
Reflecting the relevance of protease-induced ICAM-1 expression in leukocyte migration, leukocyte-endothelium interaction, as assessed by intravital microscopy, was markedly increased by trypsin.
Positive_regulation (induced) of Gene_expression (expression) of ICAM-1 in leukocyte
11) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.21 Pain Relevance 0
RESULTS: I/R plasma (withdrawn 15 min following tourniquet release) increased isolated neutrophil CD11b (P = 0.03), CD18 (P = 0.01) and endothelial intercellular adhesion molecule-1 (ICAM-1) (P = 0.008) expression compared to baseline.
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1 in neutrophil
12) Confidence 0.64 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15717706 Disease Relevance 0.06 Pain Relevance 0
mediated expression of ICAM-1 in HCPSMC
Positive_regulation (mediated) of Gene_expression (expression) of ICAM-1
13) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
mediated expression of ICAM-1 indicate the existence of redundant pathways.
Positive_regulation (mediated) of Gene_expression (expression) of ICAM-1
14) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.06 Pain Relevance 0
mediated expression of ICAM-1 in HCAEC
Positive_regulation (mediated) of Gene_expression (expression) of ICAM-1
15) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
mediated expression of ICAM-1 in HUVEC
Positive_regulation (mediated) of Gene_expression (expression) of ICAM-1
16) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0.03
In an earlier report we have demonstrated that the expression of ICAM-1 in HCMSMC and HCPSMC is increased in a time and dose dependent manner after treatment with TNF-?
Positive_regulation (increased) of Gene_expression (expression) of ICAM-1
17) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.09 Pain Relevance 0.11
B mediated expression of ICAM-1.
Positive_regulation (mediated) of Gene_expression (expression) of ICAM-1
18) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
mediated expression of ICAM-1.
Positive_regulation (mediated) of Gene_expression (expression) of ICAM-1
19) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
induced expression of ICAM-1 (Fig. 4A).
Positive_regulation (induced) of Gene_expression (expression) of ICAM-1
20) Confidence 0.64 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0.03

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