INT63349

Context Info Confidence 0.75 First Reported 1996 Last Reported 2010 Negated 5 Speculated 3 Reported most in Body Documents 199 Total Number 202 Disease Relevance 166.03 Pain Relevance 36.76

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1) plasma membrane (PECAM1)

Anatomy Link Frequency endothelial cells 25 leukocyte 22 endothelium 8 granulocytes 7 neural 6 PECAM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2795 100.00 cytokine 1213 100.00 rheumatoid arthritis 1202 100.00 metalloproteinase 503 100.00 Glutamate 53 100.00 chemokine 610 99.90 Inflammatory mediators 79 99.80 cINOD 94 99.56 Arthritis 404 99.32 Morphine 33 99.10

Disease Link Frequency Relevance Heat Adhesions 3584 100.00 INFLAMMATION 3147 100.00 Rheumatoid Arthritis 1213 100.00 Cancer 994 100.00 Necrosis 175 100.00 Psoriasis 160 100.00 Infection 371 99.98 Nicotine Addiction 4213 99.92 Crohn's Disease 109 99.92 Polymyalgia Rheumatica 38 99.92

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Adhesion molecule (ICAM-1) expression on endothelial cells: 20,000 Endothelial cell (HDMEC, Lonza Inc., USA) per well in quadruplicate wells were treated with medium, vehicle, TNF?

Gene_expression (expression) of Adhesion molecule in endothelial cells associated with adhesions

1) Confidence 0.75 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.21 Pain Relevance 0.11

Topical treatment with capsiate significantly decreased UVB-induced skin damage and inhibited the expression of COX-2, proinflammatory cytokines, and angiogenic factors, including platelet/endothelial cell adhesion molecule-1 and intercellular adhesion molecule-1.

Gene_expression (expression) of platelet/endothelial cell adhesion molecule in endothelial cell associated with adhesions and cytokine

2) Confidence 0.75 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.33 Pain Relevance 0.29

Turnout cells expressed the endothelial markers CD31,

Gene_expression (expressed) of CD31

3) Confidence 0.73 Published 1997 Journal Sarcoma Section Abstract Doc Link PMC2395360 Disease Relevance 0.70 Pain Relevance 0.22

RESULTS: In a drug free group, digestion of a single tablet of aspirin resulted in a significantly (p<0.05) diminished expression of PECAM-1, GP IIb, fibrinogen binding with PAC-1 antibody, GP Ib, P-selectin, and CD151.

Gene_expression (expression) of PECAM-1

4) Confidence 0.69 Published 2001 Journal Thromb. Res. Section Body Doc Link 11728532 Disease Relevance 0.06 Pain Relevance 0

These differences reached statistical significance (p<0.05) for PECAM-1, GPIIb, and P-selectin expression.

Gene_expression (expression) of PECAM-1

5) Confidence 0.69 Published 2001 Journal Thromb. Res. Section Body Doc Link 11728532 Disease Relevance 0.05 Pain Relevance 0

METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.

Spec (determine) Gene_expression (expression) of CD31 in neutrophil

6) Confidence 0.62 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0

In addition, we used immunohistochemistry to assess the expression of the vascular markers VEGF and CD31 as well as the bone formation marker ALP.

Gene_expression (expression) of CD31

7) Confidence 0.62 Published 2010 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 20560451 Disease Relevance 0.17 Pain Relevance 0.06

Immunohistochemistry plays an important role in identifying these rare entities, confirming the endothelial origin of the neoplasm with the expression of at least one of the vascular markers CD31, CD34, or factor VIII-related antigen.

Gene_expression (expression) of CD31 associated with cancer

8) Confidence 0.59 Published 2010 Journal Pathol. Res. Pract. Section Abstract Doc Link 20089367 Disease Relevance 1.11 Pain Relevance 0

Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).

Neg (negative) Gene_expression (negative) of CD31 in smooth muscle

9) Confidence 0.59 Published 2005 Journal Pathologica Section Abstract Doc Link 16619980 Disease Relevance 0.15 Pain Relevance 0.08

Under these conditions, we observed the formation of colonies with spindle-like cells expressing Ve-cadherin and CD31 endothelial markers from both normal and dystrophic CD133+CXCR4+CD34- cell populations.

Gene_expression (expressing) of CD31

10) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.13 Pain Relevance 0

Using a human Stem Cell Gene Array, we found that the CD133+CXCR4+CD34- sorted cells expressed genes reflective of vascular progenitors, including CD31, FZD 2/3/4/7, CXCR4, LIFR, and Notch promoter 1 (data not shown).

Gene_expression (expressed) of CD31 in Notch

11) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.39 Pain Relevance 0

Therefore, attention has inevitably turned to examinations of the influence of tobacco smoking on adhesion molecule expression by vascular endothelial cells.

Gene_expression (expression) of adhesion molecule in endothelial cells associated with nicotine addiction and adhesions

12) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.05 Pain Relevance 0.15

However, although smokers had thus retained the ability to upregulate adhesion molecule expression, an integral part of the inflammatory response, other signs of smoking-induced immune dysregulation in the gingival microvasculature were apparent.

Gene_expression (expression) of adhesion molecule associated with inflammatory response, nicotine addiction and adhesions

13) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.72 Pain Relevance 0.17

In summary, there is growing evidence that smoking influences tissue and cellular adhesion molecule expression profiles in several smoking-induced diseases: COPD; vascular diseases; and CIPD.

Gene_expression (expression) of adhesion molecule associated with nicotine addiction, chronic obstructive pulmonary disease, periodontal disease, increased venous pressure under development, disease and adhesions

14) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.98 Pain Relevance 0.07

B activation in the upregulation of endothelial adhesion molecule expression.

Gene_expression (expression) of adhesion molecule associated with adhesions

15) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.18 Pain Relevance 0.14

In summary, there is growing evidence that smoking influences tissue and cellular adhesion molecule expression profiles in several smoking-induced diseases: COPD; vascular diseases; and CIPD.

Gene_expression (expression) of adhesion molecule associated with nicotine addiction, chronic obstructive pulmonary disease, periodontal disease, increased venous pressure under development, disease and adhesions

16) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.98 Pain Relevance 0.07

However, a recent comparison of adhesion molecule expression profiles on leukocyte (L-selectin, VLA-4, and the three ?

Gene_expression (expression) of adhesion molecule in leukocyte associated with adhesions

17) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.11 Pain Relevance 0

However, although smokers had thus retained the ability to upregulate adhesion molecule expression, an integral part of the inflammatory response, other signs of smoking-induced immune dysregulation in the gingival microvasculature were apparent.

Gene_expression (expression) of adhesion molecule associated with inflammatory response, nicotine addiction and adhesions

18) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.72 Pain Relevance 0.17

B activation in the upregulation of endothelial adhesion molecule expression.

Gene_expression (expression) of adhesion molecule associated with adhesions

19) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.18 Pain Relevance 0.14

Therefore, attention has inevitably turned to examinations of the influence of tobacco smoking on adhesion molecule expression by vascular endothelial cells.

Gene_expression (expression) of adhesion molecule in endothelial cells associated with nicotine addiction and adhesions

20) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.05 Pain Relevance 0.15

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