INT63349

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 199
Total Number 202
Disease Relevance 166.03
Pain Relevance 36.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
endothelial cells 25
leukocyte 22
endothelium 8
granulocytes 7
neural 6
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2795 100.00 Very High Very High Very High
cytokine 1213 100.00 Very High Very High Very High
rheumatoid arthritis 1202 100.00 Very High Very High Very High
metalloproteinase 503 100.00 Very High Very High Very High
Glutamate 53 100.00 Very High Very High Very High
chemokine 610 99.90 Very High Very High Very High
Inflammatory mediators 79 99.80 Very High Very High Very High
cINOD 94 99.56 Very High Very High Very High
Arthritis 404 99.32 Very High Very High Very High
Morphine 33 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 3584 100.00 Very High Very High Very High
INFLAMMATION 3147 100.00 Very High Very High Very High
Rheumatoid Arthritis 1213 100.00 Very High Very High Very High
Cancer 994 100.00 Very High Very High Very High
Necrosis 175 100.00 Very High Very High Very High
Psoriasis 160 100.00 Very High Very High Very High
Infection 371 99.98 Very High Very High Very High
Nicotine Addiction 4213 99.92 Very High Very High Very High
Crohn's Disease 109 99.92 Very High Very High Very High
Polymyalgia Rheumatica 38 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adhesion molecule (ICAM-1) expression on endothelial cells: 20,000 Endothelial cell (HDMEC, Lonza Inc., USA) per well in quadruplicate wells were treated with medium, vehicle, TNF?
Gene_expression (expression) of Adhesion molecule in endothelial cells associated with adhesions
1) Confidence 0.75 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.21 Pain Relevance 0.11
Topical treatment with capsiate significantly decreased UVB-induced skin damage and inhibited the expression of COX-2, proinflammatory cytokines, and angiogenic factors, including platelet/endothelial cell adhesion molecule-1 and intercellular adhesion molecule-1.
Gene_expression (expression) of platelet/endothelial cell adhesion molecule in endothelial cell associated with adhesions and cytokine
2) Confidence 0.75 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20123015 Disease Relevance 0.33 Pain Relevance 0.29
Turnout cells expressed the endothelial markers CD31,
Gene_expression (expressed) of CD31
3) Confidence 0.73 Published 1997 Journal Sarcoma Section Abstract Doc Link PMC2395360 Disease Relevance 0.70 Pain Relevance 0.22
RESULTS: In a drug free group, digestion of a single tablet of aspirin resulted in a significantly (p<0.05) diminished expression of PECAM-1, GP IIb, fibrinogen binding with PAC-1 antibody, GP Ib, P-selectin, and CD151.
Gene_expression (expression) of PECAM-1
4) Confidence 0.69 Published 2001 Journal Thromb. Res. Section Body Doc Link 11728532 Disease Relevance 0.06 Pain Relevance 0
These differences reached statistical significance (p<0.05) for PECAM-1, GPIIb, and P-selectin expression.
Gene_expression (expression) of PECAM-1
5) Confidence 0.69 Published 2001 Journal Thromb. Res. Section Body Doc Link 11728532 Disease Relevance 0.05 Pain Relevance 0
METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.
Spec (determine) Gene_expression (expression) of CD31 in neutrophil
6) Confidence 0.62 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0
In addition, we used immunohistochemistry to assess the expression of the vascular markers VEGF and CD31 as well as the bone formation marker ALP.
Gene_expression (expression) of CD31
7) Confidence 0.62 Published 2010 Journal Okajimas Folia Anat Jpn Section Abstract Doc Link 20560451 Disease Relevance 0.17 Pain Relevance 0.06
Immunohistochemistry plays an important role in identifying these rare entities, confirming the endothelial origin of the neoplasm with the expression of at least one of the vascular markers CD31, CD34, or factor VIII-related antigen.
Gene_expression (expression) of CD31 associated with cancer
8) Confidence 0.59 Published 2010 Journal Pathol. Res. Pract. Section Abstract Doc Link 20089367 Disease Relevance 1.11 Pain Relevance 0
Immunohistochemically, the neoplastic cells were positive for vimentin, smooth muscle actin, desmin and calponin, negative for S-100 protein, CD34, CD31 and cytokeratins (AE1/AE3, Cam 5.2).
Neg (negative) Gene_expression (negative) of CD31 in smooth muscle
9) Confidence 0.59 Published 2005 Journal Pathologica Section Abstract Doc Link 16619980 Disease Relevance 0.15 Pain Relevance 0.08
Under these conditions, we observed the formation of colonies with spindle-like cells expressing Ve-cadherin and CD31 endothelial markers from both normal and dystrophic CD133+CXCR4+CD34- cell populations.
Gene_expression (expressing) of CD31
10) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.13 Pain Relevance 0
Using a human Stem Cell Gene Array, we found that the CD133+CXCR4+CD34- sorted cells expressed genes reflective of vascular progenitors, including CD31, FZD 2/3/4/7, CXCR4, LIFR, and Notch promoter 1 (data not shown).
Gene_expression (expressed) of CD31 in Notch
11) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.39 Pain Relevance 0
Therefore, attention has inevitably turned to examinations of the influence of tobacco smoking on adhesion molecule expression by vascular endothelial cells.
Gene_expression (expression) of adhesion molecule in endothelial cells associated with nicotine addiction and adhesions
12) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.05 Pain Relevance 0.15
However, although smokers had thus retained the ability to upregulate adhesion molecule expression, an integral part of the inflammatory response, other signs of smoking-induced immune dysregulation in the gingival microvasculature were apparent.
Gene_expression (expression) of adhesion molecule associated with inflammatory response, nicotine addiction and adhesions
13) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.72 Pain Relevance 0.17
In summary, there is growing evidence that smoking influences tissue and cellular adhesion molecule expression profiles in several smoking-induced diseases: COPD; vascular diseases; and CIPD.
Gene_expression (expression) of adhesion molecule associated with nicotine addiction, chronic obstructive pulmonary disease, periodontal disease, increased venous pressure under development, disease and adhesions
14) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.98 Pain Relevance 0.07
B activation in the upregulation of endothelial adhesion molecule expression.
Gene_expression (expression) of adhesion molecule associated with adhesions
15) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.18 Pain Relevance 0.14
In summary, there is growing evidence that smoking influences tissue and cellular adhesion molecule expression profiles in several smoking-induced diseases: COPD; vascular diseases; and CIPD.
Gene_expression (expression) of adhesion molecule associated with nicotine addiction, chronic obstructive pulmonary disease, periodontal disease, increased venous pressure under development, disease and adhesions
16) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.98 Pain Relevance 0.07
However, a recent comparison of adhesion molecule expression profiles on leukocyte (L-selectin, VLA-4, and the three ?
Gene_expression (expression) of adhesion molecule in leukocyte associated with adhesions
17) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.11 Pain Relevance 0
However, although smokers had thus retained the ability to upregulate adhesion molecule expression, an integral part of the inflammatory response, other signs of smoking-induced immune dysregulation in the gingival microvasculature were apparent.
Gene_expression (expression) of adhesion molecule associated with inflammatory response, nicotine addiction and adhesions
18) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.72 Pain Relevance 0.17
B activation in the upregulation of endothelial adhesion molecule expression.
Gene_expression (expression) of adhesion molecule associated with adhesions
19) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.18 Pain Relevance 0.14
Therefore, attention has inevitably turned to examinations of the influence of tobacco smoking on adhesion molecule expression by vascular endothelial cells.
Gene_expression (expression) of adhesion molecule in endothelial cells associated with nicotine addiction and adhesions
20) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.05 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox