INT6335

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Context Info
Confidence 0.44
First Reported 1980
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 39
Total Number 40
Disease Relevance 10.88
Pain Relevance 7.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TSPO) mitochondrion (TSPO) aging (TSPO)
response to stress (TSPO)
Anatomy Link Frequency
bladder 2
CNS 2
erythrocytes 1
ear skin 1
pore 1
TSPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 43 100.00 Very High Very High Very High
cINOD 19 100.00 Very High Very High Very High
gABA 12 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
Cholecystokinin 2 99.80 Very High Very High Very High
agonist 15 99.76 Very High Very High Very High
Central nervous system 17 99.72 Very High Very High Very High
lidocaine 2 99.42 Very High Very High Very High
imagery 12 99.34 Very High Very High Very High
Antihistamine 5 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bladder Disease 34 100.00 Very High Very High Very High
Breast Cancer 5 99.76 Very High Very High Very High
Epilepsy 20 99.66 Very High Very High Very High
Cancer 162 99.54 Very High Very High Very High
Apoptosis 63 99.26 Very High Very High Very High
INFLAMMATION 133 98.96 Very High Very High Very High
Malformations Of Cortical Development 10 98.92 Very High Very High Very High
Overactive Bladder 29 98.56 Very High Very High Very High
Panic Disorder 1 98.44 Very High Very High Very High
Anxiety Disorder 15 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, an investigation of a direct influence of GABA-A agonist propofol, GABA-A and PBR-agonist etomidate, and the local anesthetic drug lidocaine, which can also bind to the GABA-A receptor and PBR, on migration of breast carcinoma cells was performed.
PBR Binding (bind) of associated with gaba, breast cancer, agonist, lidocaine and local anesthetic
1) Confidence 0.44 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 12139540 Disease Relevance 0.35 Pain Relevance 0.49
The 2 aryl-3-indoleacetamides (FGIN-1) are a new class of compounds that potently (nM) and selectively bind to glial mitochondrial diazepam binding inhibitor (DBI) receptors (MDR), previously called peripheral benzodiazepine receptors, and increase mitochondrial steroidogenesis.
DBI Binding (bind) of
2) Confidence 0.36 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1326631 Disease Relevance 0 Pain Relevance 0.21
l of 0.5% biotin free BSA (Sigma-Aldrich)-PBS and blocked with 200 ?
PBS Binding (biotin) of
3) Confidence 0.36 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0 Pain Relevance 0
Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice.
PBR Binding (binding) of associated with agonist and imagery
4) Confidence 0.36 Published 2009 Journal Exp. Neurol. Section Title Doc Link 19320004 Disease Relevance 0.82 Pain Relevance 0.30
When bound to cholesterol alone, OSBP1 exists in the cytoplasm and ER, where it also binds two phosphatases, the serine/threonine phosphatase PP2A and a PTPPBS class tyrosine phosphatase.
PBS Binding (binds) of
5) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
Lastly, probably indirect interactions between benzodiazepine receptor and cholecystokinin system are important to be considered, with possible consequences on anxiety regulations.
benzodiazepine receptor Binding (interactions) of associated with anxiety disorder and cholecystokinin
6) Confidence 0.35 Published 1995 Journal Encephale Section Abstract Doc Link 7781584 Disease Relevance 0.53 Pain Relevance 0.37
This prescribed non-benzodiazepine anxiolytic was shown previously to stimulate neurosteroidogenesis in its early step after binding to the mitochondrial translocator protein complex (TSPO).
TSPO Binding (binding) of associated with anxiety disorder
7) Confidence 0.35 Published 2009 Journal Pain Section Abstract Doc Link 19786322 Disease Relevance 0.65 Pain Relevance 0.66
Several benzodiazepines were shown to bind irreversibly to the receptor upon exposure to ultraviolet light and these agents can be used to facilitate solubilization and purification of the benzodiazepine receptor.
benzodiazepine receptor Binding (solubilization) of
8) Confidence 0.33 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6998742 Disease Relevance 0 Pain Relevance 0.17
A submerged MBR of approximately 21 L active volume equipped with two flat sheet membranes (A4 size, area 0.106 m2, pore size 0.4 ?
MBR Binding (equipped) of in pore
9) Confidence 0.29 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0 Pain Relevance 0.03
This, in broad terms, requires that pharmacoeconomic experts on the Pharmaceutical Benefits Advisory Committee (PBAC), can only recommend PBS listing of a pharmaceutical submitted by its manufacturer after a positive determination of its cost-effectiveness in relation to alternative therapies (whether or not involving drugs).
PBS Binding (recommend) of
10) Confidence 0.26 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1894805 Disease Relevance 0.07 Pain Relevance 0
Most importantly, in relation to the PBS and the AUSFTA Annex 2C provisions he stated:
PBS Binding (relation) of
11) Confidence 0.26 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1894805 Disease Relevance 0 Pain Relevance 0
IBP is associated with extremely low demands on health care resources and maximum responsiveness to patient needs.
IBP Binding (associated) of
12) Confidence 0.24 Published 2001 Journal Journal of Medical Internet Research Section Body Doc Link PMC1761892 Disease Relevance 0.14 Pain Relevance 0
Several PET receptor ligands have been used to investigate the neurochemical basis of the epilepsies. 11C-Flumazenil binds to the central benzodiazepine receptor (cBZR)-gamma-aminobutyric acid (GABA) A receptor complex; 11C-diprenorphine, 18F-cyclofoxy, and 11C-carfentanil to opiate receptors; and 11C-Deprenyl to monoamine oxidase B.
benzodiazepine receptor Binding (binds) of associated with epilepsy, gaba, opiate and monoamine
13) Confidence 0.22 Published 1999 Journal Adv Neurol Section Abstract Doc Link 10514872 Disease Relevance 0.21 Pain Relevance 0.30
There followed a search for endogenous substances capable of binding to the benzodiazepine receptor, with CNS inhibitory effects.
benzodiazepine receptor Binding (binding) of in CNS associated with central nervous system
14) Confidence 0.21 Published 1998 Journal Am J Ther Section Abstract Doc Link 10099035 Disease Relevance 0.82 Pain Relevance 0.27
This has refocused research to discover whether one or more endogenous substances that bind to the benzodiazepine receptor in the CNS are responsible for the inhibition of CNS function of advanced liver failure.
benzodiazepine receptor Binding (bind) of in CNS associated with liver failure and central nervous system
15) Confidence 0.21 Published 1998 Journal Am J Ther Section Abstract Doc Link 10099035 Disease Relevance 0.81 Pain Relevance 0.56
Finally, the lowest bias between the IBP and IGP was obtained with the bladder infused with 50 ml saline.
IBP Binding (bias) of in bladder
16) Confidence 0.21 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0 Pain Relevance 0
Several endogenous ligands for the benzodiazepine receptor(s) have been postulated.
benzodiazepine receptor Binding (ligands) of
17) Confidence 0.19 Published 1984 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6146163 Disease Relevance 0.25 Pain Relevance 0.31
This latter group, which competitively antagonizes the pharmacological and biochemical effects of the benzodiazepines, has the highest affinity for the benzodiazepine receptor of all compounds thus far examined; however, none of these compounds has been conclusively identified as the endogenous ligand akin to the enkephalins and endorphins at the opiate receptor.
benzodiazepine receptor Spec (examined) Binding (affinity) of associated with opiate and enkephalin
18) Confidence 0.19 Published 1984 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6146163 Disease Relevance 0.22 Pain Relevance 0.36
Heterocycles as physiological ligands for the benzodiazepine receptor and for other binding sites.
benzodiazepine receptor Binding (ligands) of
19) Confidence 0.18 Published 1989 Journal Pharmacol. Res. Section Title Doc Link 2560546 Disease Relevance 0 Pain Relevance 0.11
Extensive training is needed to achieve the required proficiency level, a great deal of which involves training of operator interaction with the IBP interface [4–7].
IBP Binding (interaction) of
20) Confidence 0.12 Published 2010 Journal World J Surg Section Body Doc Link PMC2848730 Disease Relevance 0 Pain Relevance 0

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