INT63351

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 16.06
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
neutrophil 8
leukocyte 6
neural 4
forebrain 2
coronary artery 2
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 248 100.00 Very High Very High Very High
cytokine 69 100.00 Very High Very High Very High
chemokine 14 100.00 Very High Very High Very High
addiction 3 99.28 Very High Very High Very High
Morphine 15 99.18 Very High Very High Very High
rheumatoid arthritis 54 98.16 Very High Very High Very High
ketamine 16 98.10 Very High Very High Very High
withdrawal 12 97.72 Very High Very High Very High
Angina 13 97.64 Very High Very High Very High
Arthritis 65 93.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 277 100.00 Very High Very High Very High
Adhesions 270 100.00 Very High Very High Very High
Stress 75 99.44 Very High Very High Very High
Morphine Dependence 2 99.28 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 44 99.20 Very High Very High Very High
Apoptosis 110 98.56 Very High Very High Very High
Rheumatoid Arthritis 54 98.16 Very High Very High Very High
Nicotine Addiction 366 97.72 Very High Very High Very High
Cv General 3 Under Development 13 97.64 Very High Very High Very High
Vasculitis 1 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In a drug free group, digestion of a single tablet of aspirin resulted in a significantly (p<0.05) diminished expression of PECAM-1, GP IIb, fibrinogen binding with PAC-1 antibody, GP Ib, P-selectin, and CD151.
Negative_regulation (diminished) of Gene_expression (expression) of PECAM-1
1) Confidence 0.52 Published 2001 Journal Thromb. Res. Section Body Doc Link 11728532 Disease Relevance 0.06 Pain Relevance 0
Taken together with the nearly complete lack of CD31 expression (>99%), this strongly suggests that endothelial cells were not present in significant quantities in cultures from AG explants.
Negative_regulation (lack) of Gene_expression (expression) of CD31 in endothelial cells
2) Confidence 0.34 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.06 Pain Relevance 0
METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of CD31 in neutrophil
3) Confidence 0.34 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0
However, a recent comparison of adhesion molecule expression profiles on leukocyte (L-selectin, VLA-4, and the three ?
Negative_regulation (comparison) of Gene_expression (expression) of adhesion molecule in leukocyte associated with adhesions
4) Confidence 0.28 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.17 Pain Relevance 0
However, a recent comparison of adhesion molecule expression profiles on leukocyte (L-selectin, VLA-4, and the three ?
Negative_regulation (comparison) of Gene_expression (expression) of adhesion molecule in leukocyte associated with adhesions
5) Confidence 0.28 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.17 Pain Relevance 0
Morphine dependence was also associated with a drastic reduction in the expression levels of the polysialylated form of neural cell adhesion molecule (68% of control), an adhesion molecule expressed by newly generated neurons and involved in cell migration and structural plasticity.
Negative_regulation (reduction) of Gene_expression (expression) of adhesion molecule in neural associated with addiction, adhesions and morphine
6) Confidence 0.23 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15673448 Disease Relevance 0.62 Pain Relevance 1.03
Morphine dependence was also associated with a drastic reduction in the expression levels of the polysialylated form of neural cell adhesion molecule (68% of control), an adhesion molecule expressed by newly generated neurons and involved in cell migration and structural plasticity.
Negative_regulation (reduction) of Gene_expression (expressed) of adhesion molecule in neural associated with addiction, adhesions and morphine
7) Confidence 0.23 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15673448 Disease Relevance 0.63 Pain Relevance 1.09
Morphine, via nitric oxide, has the potential to diminish adhesion molecule expression and in so doing calm an inflammatory process between immunocytes and the endothelial surface.
Negative_regulation (diminish) of Gene_expression (expression) of adhesion molecule associated with inflammation, adhesions and morphine
8) Confidence 0.17 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9610675 Disease Relevance 0.38 Pain Relevance 0.67
Cilostazol inhibits high glucose-mediated endothelial-neutrophil adhesion by decreasing adhesion molecule expression via NO production.
Negative_regulation (decreasing) of Gene_expression (expression) of adhesion molecule in neutrophil associated with adhesions
9) Confidence 0.13 Published 2004 Journal Microvasc. Res. Section Title Doc Link 15313121 Disease Relevance 1.10 Pain Relevance 0.09
We have previously demonstrated that intra-articular glucocorticoids decrease synovial expression of ICAM-1 (intracellular adhesion molecule-1), an adhesion molecule essential for leukocyte migration, despite minimal changes in the inflammatory phenotype of the endothelial synovial cells [15].
Negative_regulation (decrease) of Gene_expression (expression) of adhesion molecule in articular associated with inflammation and adhesions
10) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656252 Disease Relevance 0.68 Pain Relevance 0.23
Decreased monocytic cell influx could be mediated by an effect of FP on production of monocyte-associated chemotactic factors or decreased adhesion molecule expression on endothelial cells lining the postcapillary venules.
Negative_regulation (decreased) of Gene_expression (expression) of adhesion molecule in venules associated with adhesions
11) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.19 Pain Relevance 0
In particular, rebamipide shows a variety of anti-inflammatory actions, such as scavenging of free radicals, inhibition of ROS and protease production by neutrophils, inhibition of adhesion molecule expression, and inhibition of cytokine production [46, 47, 48].
Negative_regulation (inhibition) of Gene_expression (expression) of adhesion molecule in neutrophils associated with inflammation, adhesions and cytokine
12) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 1.08 Pain Relevance 0.54
In our model we demonstrated that CORM-2 treatment reduced the extent of apoptosis and ameliorated the pro-inflammatory stress response as evidenced by a reduction in the expression of pro-inflammatory cytokines, vascular endothelial adhesion molecule and a markedly reduced influx of leukocytes
Negative_regulation (reduction) of Gene_expression (expression) of adhesion molecule in leukocytes associated with stress, inflammation, apoptosis, adhesions and cytokine
13) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.99 Pain Relevance 0.28
The reduction in expression of adhesion molecule on monocytes and lymphocytes and the concentrations of CRP and sICAM-1 may crucially contribute to the clinical benefit of atorvastatin in coronary artery disease, independent of cholesterol lowering effects.
Negative_regulation (reduction) of Gene_expression (expression) of adhesion molecule in coronary artery associated with coronary artery disease and adhesions
14) Confidence 0.01 Published 2007 Journal Rom J Intern Med Section Abstract Doc Link 18333374 Disease Relevance 1.12 Pain Relevance 0.55
In experiments with cultured newborn rat forebrain cells, ketamine caused an increase in DNA fragmentation, elevated immunoreactivity to nitrotyrosine, a marked reduction in the expression of neuronal marker polysialic acid neural cell adhesion molecule and a reduction in mitochondrial metabolism.
Negative_regulation (reduction) of Gene_expression (expression) of adhesion molecule in forebrain associated with ketamine and adhesions
15) Confidence 0.01 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.37 Pain Relevance 0.29
Most impressively, virtually all alterations in extracellular matrix and adhesion molecule gene expression induced by monocrotaline were fully or partially abrogated by tolafentrine (12 genes given in Figure 10).


Negative_regulation (abrogated) of Gene_expression (expression) of adhesion molecule in extracellular matrix associated with adhesions
16) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.62 Pain Relevance 0.03
CD49d was not modified by sensitization or antigen challenge, but feG treatment significantly reduced the expression of this adhesion molecule in OA-exposed animals to values that were 50% of those measured in rats receiving antigen only.


Negative_regulation (reduced) of Gene_expression (expression) of adhesion molecule associated with adhesions
17) Confidence 0.00 Published 2002 Journal BMC Physiol Section Body Doc Link PMC126222 Disease Relevance 0.38 Pain Relevance 0.10
prevents T cell accumulation in the joint, but they are likely to include reduced chemokine and adhesion molecule expression in the joint, as has been proposed for human RA (16, 17).
Negative_regulation (reduced) of Gene_expression (expression) of adhesion molecule in joint associated with chemokine, rheumatoid arthritis and adhesions
18) Confidence 0.00 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.68 Pain Relevance 0.27
The observed decrease in adhesion molecule expression could be explained in part by the reduction in vascularity discussed below.
Negative_regulation (decrease) of Gene_expression (expression) of adhesion molecule associated with adhesions
19) Confidence 0.00 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464872 Disease Relevance 1.09 Pain Relevance 0.36
HTS is a potent inhibitor of neutrophil function, downregulating neutrophil oxidative burst activity [21], reducing neutrophil adhesion molecule expression [22] and suppressing neutrophil activation and the release of pro-inflammatory cytokines [5,23].
Negative_regulation (reducing) of Gene_expression (expression) of adhesion molecule in neutrophil associated with inflammation, adhesions and cytokine
20) Confidence 0.00 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.47 Pain Relevance 0.21

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