INT63356

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Context Info
Confidence 0.23
First Reported 1996
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.29
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD44) plasma membrane (CD44)
Anatomy Link Frequency
neutrophils 1
CD44 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 99.84 Very High Very High Very High
Snapping jaw 1 87.92 High High
fibrosis 74 86.32 High High
Inflammatory response 11 85.60 High High
Inflammation 71 69.60 Quite High
cytokine 26 57.04 Quite High
Nicotine 20 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
transdermal 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 212 100.00 Very High Very High Very High
Pancreatitis 2 99.84 Very High Very High Very High
Adenocarcinoma 6 98.20 Very High Very High Very High
Nicotine Addiction 368 97.72 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 44 96.52 Very High Very High Very High
Malignant Neoplastic Disease 6 95.64 Very High Very High Very High
Disease 59 91.84 High High
Metastasis 12 90.44 High High
Temporomandibular Joint Syndrome 1 87.92 High High
Pulmonary Fibrosis 65 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in surface markers (CD105, CD44, SSEA, PDGFR alpha) after the differentiation treatments were also analyzed.
Regulation (Changes) of CD44
1) Confidence 0.23 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 18454697 Disease Relevance 0.09 Pain Relevance 0.09
Although there is extensive, and growing, knowledge of the molecular mechanisms that regulate transcription, expression, and shedding of ICAM-1, CD44, and other adhesion molecules, studies that address how tobacco smoke may influence these control networks are minimal.
Regulation (regulate) of CD44 associated with nicotine addiction and adhesions
2) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.87 Pain Relevance 0.08
Although there is extensive, and growing, knowledge of the molecular mechanisms that regulate transcription, expression, and shedding of ICAM-1, CD44, and other adhesion molecules, studies that address how tobacco smoke may influence these control networks are minimal.
Regulation (regulate) of CD44 associated with nicotine addiction and adhesions
3) Confidence 0.23 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.87 Pain Relevance 0.08
The effects on TIMP-1 and MMP-1 expression appeared to be mostly dependent on CD44, while the effect on MMP-7 expression was dependent on CD44 and integrin signaling.
Regulation (dependent) of CD44
4) Confidence 0.18 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.40 Pain Relevance 0.20
In contrast, the expression of other adhesion molecules by neutrophils was unaffected (CD11a, CD31, CD44) or slightly increased (CD11b).
Neg (unaffected) Regulation (unaffected) of CD44 in neutrophils
5) Confidence 0.17 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.12 Pain Relevance 0
To our knowledge the effect of

CVVHD on the important adhesion molecules CD11a, CD11b, CD18 and CD44 has not been investigated before.

Spec (investigated) Regulation (effect) of CD44 associated with adhesions
6) Confidence 0.14 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.07 Pain Relevance 0
This study has investigated standard CD44 (CD44s) and CD44v6 expression immunohistochemically in 6 samples of normal pancreatic tissue, 4 of tissue affected by chronic pancreatitis, and 24 of tissue from metastasizing and nonmetastasizing pancreatic adenocarcinomas.
Regulation (affected) of CD44s associated with adenocarcinoma and chronic pancreatitis
7) Confidence 0.03 Published 1996 Journal Virchows Arch. Section Abstract Doc Link 8972753 Disease Relevance 0.88 Pain Relevance 0.17

General Comments

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