INT63357

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Context Info
Confidence 0.33
First Reported 1996
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
dura mater 4
leukocyte 2
neutrophil 2
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 96.52 Very High Very High Very High
Inflammation 11 96.12 Very High Very High Very High
Multiple sclerosis 6 93.28 High High
Restless leg syndrome 2 80.28 Quite High
Pain 1 69.04 Quite High
Migraine 4 50.00 Quite Low
depression 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 13 98.80 Very High Very High Very High
INFLAMMATION 13 96.12 Very High Very High Very High
Disease Progression 1 94.92 High High
Demyelinating Disease 7 93.28 High High
Encephalitis 1 92.48 High High
Amputation 1 87.92 High High
Peripheral Arterial Disease 5 86.24 High High
Paralysis 1 81.44 Quite High
Increased Venous Pressure Under Development 8 80.28 Quite High
Pain 1 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of CD11a in neutrophil
1) Confidence 0.33 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0
Lovastatin treatment also attenuated the transmigration of mononuclear cells by downregulating the expression of leukocyte function antigen-1 (LFA-1), a ligand for intercellular adhesion molecule (ICAM), in endothelial-leukocyte interaction [88] and mononuclear cell infiltration into the CNS has been implicated in MS [89].
Negative_regulation (downregulating) of Gene_expression (expression) of LFA-1 in leukocyte associated with multiple sclerosis and adhesions
2) Confidence 0.09 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.59 Pain Relevance 0.56
The progressive decrease in sICAM-1 levels during attacks and the down-regulation of LFA-1 expression by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks.


Negative_regulation (down) of Gene_expression (expression) of LFA-1 in dura mater
3) Confidence 0.03 Published 2006 Journal Headache Section Body Doc Link 16492228 Disease Relevance 0.05 Pain Relevance 0
The progressive decrease in sICAM-1 levels during attacks and the down-regulation of LFA-1 expression by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks.


Negative_regulation (regulation) of Gene_expression (expression) of LFA-1 in dura mater
4) Confidence 0.03 Published 2006 Journal Headache Section Body Doc Link 16492228 Disease Relevance 0.05 Pain Relevance 0

General Comments

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