INT63361

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2010
Negated 6
Speculated 4
Reported most in Body
Documents 126
Total Number 130
Disease Relevance 71.58
Pain Relevance 12.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD44) plasma membrane (CD44)
Anatomy Link Frequency
lung 9
stem cells 7
temporomandibular joint 4
chondrocytes 3
hematopoietic cell 3
CD44 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 682 100.00 Very High Very High Very High
rheumatoid arthritis 128 100.00 Very High Very High Very High
fibrosis 106 99.96 Very High Very High Very High
diclofenac 10 99.30 Very High Very High Very High
lidocaine 24 99.28 Very High Very High Very High
COX2 46 99.26 Very High Very High Very High
cytokine 247 99.18 Very High Very High Very High
Snapping jaw 39 99.00 Very High Very High Very High
Nicotine 220 98.58 Very High Very High Very High
Inflammation 974 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 2424 100.00 Very High Very High Very High
Rheumatoid Arthritis 128 100.00 Very High Very High Very High
Pulmonary Fibrosis 65 99.96 Very High Very High Very High
Metaplasia 5 99.96 Very High Very High Very High
Adenocarcinoma 62 99.86 Very High Very High Very High
Prostate Cancer 1680 99.84 Very High Very High Very High
Apoptosis 322 99.80 Very High Very High Very High
Carcinoma 201 99.78 Very High Very High Very High
Obesity 123 99.70 Very High Very High Very High
Skin Cancer 232 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression pattern of the cell adhesion molecule CD44 standard form (CD44H) in dysfunctional human temporomandibular joint (TMJ) discs was studied immunohistochemically and compared with normal disc pattern in order to evaluate the expression of this adhesion molecule and correlate it to histopathological changes.
Gene_expression (expression) of CD44 in temporomandibular joint associated with snapping jaw and adhesions
1) Confidence 0.77 Published 2000 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11030403 Disease Relevance 0.53 Pain Relevance 0.34
In the discs showing areas of fibrocartilaginous metaplasia, CD44H expression was upregulated in fibrochondrocytes and fibroblastlike cells, especially around the chondroid tissue.
Gene_expression (expression) of CD44H associated with metaplasia
2) Confidence 0.77 Published 2000 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11030403 Disease Relevance 0.85 Pain Relevance 0.54
The expression pattern of the cell adhesion molecule CD44 standard form (CD44H) in dysfunctional human temporomandibular joint (TMJ) discs was studied immunohistochemically and compared with normal disc pattern in order to evaluate the expression of this adhesion molecule and correlate it to histopathological changes.
Gene_expression (expression) of CD44H in temporomandibular joint associated with snapping jaw and adhesions
3) Confidence 0.77 Published 2000 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11030403 Disease Relevance 0.54 Pain Relevance 0.34
CD44 standard form (CD44H) expression and distribution in dysfunctional human temporomandibular joint discs.
Gene_expression (expression) of CD44H in temporomandibular joint associated with snapping jaw
4) Confidence 0.77 Published 2000 Journal Int J Oral Maxillofac Surg Section Title Doc Link 11030403 Disease Relevance 0.72 Pain Relevance 0.48
With respect to CD44 receptor expression, incubation with lidocaine resulted in an increase of up to 43%, while suppression of up to 56% was observed with verapamil.
Gene_expression (expression) of CD44 associated with lidocaine
5) Confidence 0.77 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942692 Disease Relevance 0.30 Pain Relevance 0.54
The question is to what extent can specific modulation of the ion channel activity regulate proliferation, CD44 expression and the apoptosis behavior of human chondrocytes.
Gene_expression (expression) of CD44 in chondrocytes associated with apoptosis
6) Confidence 0.77 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942692 Disease Relevance 0.27 Pain Relevance 0.18
The influence of lidocaine and verapamil on the proliferation, CD44 expression and apoptosis behavior of human chondrocytes.
Gene_expression (expression) of CD44 in chondrocytes associated with apoptosis and lidocaine
7) Confidence 0.77 Published 2005 Journal Int. J. Mol. Med. Section Title Doc Link 15942692 Disease Relevance 0.24 Pain Relevance 0.19
METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.
Spec (determine) Gene_expression (expression) of CD44 in neutrophil
8) Confidence 0.68 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0
CD44 standard form (CD44H) expression and distribution in dysfunctional human temporomandibular joint discs.
Gene_expression (expression) of CD44 in temporomandibular joint associated with snapping jaw
9) Confidence 0.68 Published 2000 Journal Int J Oral Maxillofac Surg Section Title Doc Link 11030403 Disease Relevance 0.72 Pain Relevance 0.48
Proof of the CD44 membrane protein was performed by flow cytometry with an FITC-conjugated CD44 antibody (anti-CD44H-FITC).
Gene_expression (Proof) of CD44
10) Confidence 0.67 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942692 Disease Relevance 0.38 Pain Relevance 0.41
Our results demonstrate a significant increase in the surface expression of CD44 in PC3/OPN cells.
Gene_expression (expression) of CD44
11) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Both PC3/OPN (RGA) and PC3/SiRNA cells exhibited a decrease in the surface expression of vCD44 (lanes 3 and 4).
Gene_expression (expression) of vCD44
12) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
Surface expression of CD44 splice variants (vCD44) was markedly increased in PC3/OPN cells (Figure 2A, lane 2) as compared with PC3 cells (lane 1).
Gene_expression (expression) of CD44
13) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
The expression of MMPs and variant CD44 (vCD44) correlates strongly with cancer cell invasiveness and metastasis [13,14].
Gene_expression (expression) of CD44 associated with cancer, metalloproteinase and metastasis
14) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.94 Pain Relevance 0.28
These results suggest that the surface expression of CD44 is required for the activation of MMP-9.
Gene_expression (expression) of CD44
15) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.05 Pain Relevance 0
In many tumor cells, MMPs and CD44 were strongly expressed [12].
Gene_expression (expressed) of CD44 associated with cancer and metalloproteinase
16) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.88 Pain Relevance 0.27
Surface expression of CD44 splice variants (vCD44) was markedly increased in PC3/OPN cells (Figure 2A, lane 2) as compared with PC3 cells (lane 1).
Gene_expression (expression) of vCD44
17) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0 Pain Relevance 0
The expression of MMPs and variant CD44 (vCD44) correlates strongly with cancer cell invasiveness and metastasis [13,14].
Gene_expression (expression) of vCD44 associated with cancer, metalloproteinase and metastasis
18) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.94 Pain Relevance 0.28
Therapeutic activity of liposomal Diclofenac was evaluated in CT-26 cells that possess the CD44 hyaluronan receptors and integrins, and are a bench-mark for intracellular COX enzymes.
Gene_expression (possess) of CD44 associated with diclofenac
19) Confidence 0.65 Published 2008 Journal Biochim. Biophys. Acta Section Abstract Doc Link 18230331 Disease Relevance 0.22 Pain Relevance 0.51
Nicotine and its primary metabolite – cotinine – have both been shown to alter CD44 expression profiles on lung microvascular endothelial cells (LEISVO), and bone marrow-derived (STR-12) endothelial cells [211].
Gene_expression (expression) of CD44 in lung associated with nicotine
20) Confidence 0.65 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.78 Pain Relevance 0.12

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