INT63364

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Context Info
Confidence 0.64
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.92
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) extracellular region (Igfbp3) nucleus (Igfbp3)
Anatomy Link Frequency
plasma 3
pole 1
urine 1
Igfbp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 45 93.56 High High
Potency 2 89.84 High High
anesthesia 5 86.72 High High
chemokine 1 64.44 Quite High
Pain 2 57.52 Quite High
Clonidine 1 52.80 Quite High
Fibrositis 7 50.00 Quite Low
interstitial cystitis 3 50.00 Quite Low
Somatostatin 1 32.56 Quite Low
cytokine 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Fetal Weight 6 95.20 Very High Very High Very High
Bronchopulmonary Dysplasia 10 90.88 High High
Growth Problems 6 84.64 Quite High
Breast Cancer 3 81.52 Quite High
Sleep Disorders 6 78.80 Quite High
Cancer 3 78.36 Quite High
Chronic Fatigue Syndrome 5 75.88 Quite High
Metastasis 2 75.00 Quite High
Necrosis 1 70.52 Quite High
Intrauterine Growth Retardation 1 63.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased plasma levels of growth hormone, insulin-like growth factor (IGF)-I and IGF-binding protein 3 in pregnant rats with exercise.
Positive_regulation (Increased) of IGF-binding protein 3 in plasma
1) Confidence 0.64 Published 2006 Journal Tohoku J. Exp. Med. Section Title Doc Link 16340176 Disease Relevance 0.08 Pain Relevance 0.06
These results indicate that maternal exercise significantly increases plasma levels of GH, IGF-I and IGFBP-3 in the late period of pregnancy but causes adverse effects on fetal growth.
Positive_regulation (increases) of IGFBP-3 in plasma
2) Confidence 0.64 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340176 Disease Relevance 0.15 Pain Relevance 0.08
Plasma GH and IGF-I levels were elevated in exercising pregnant rats on D14 and D20, respectively, when compared to controls, and IGFBP-3 levels were increased on D14 and D20.
Positive_regulation (increased) of IGFBP-3 in Plasma
3) Confidence 0.64 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340176 Disease Relevance 0.17 Pain Relevance 0.09
Our data suggests that the upregulation of IGFBP-3 seen with exposure to the bone microenvironment is directly linked to an increase in TGF-beta mediated cell proliferation.
Positive_regulation (upregulation) of IGFBP-3
4) Confidence 0.57 Published 2003 Journal Clin. Exp. Metastasis Section Abstract Doc Link 14598881 Disease Relevance 0.81 Pain Relevance 0.09
The HN analog F6AHN has a single amino acid substitution of alanine for phenylalanine in position 6; this substitution abrogates IGFBP-3 binding.
Positive_regulation (abrogates) of IGFBP-3
5) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0.04
During E2, there was a small significant increase in IGFBP-3 values (1.06+/-0.58 vs. 1.20+/-0.69 mg/L, P < 0.02).
Positive_regulation (increase) of IGFBP-3
6) Confidence 0.12 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11095449 Disease Relevance 0.22 Pain Relevance 0.05
Earlier, we have shown that the first months of life are characterized by a pole reversal of the somatotropic axis: IGFBP-1 and 2 decrease and IGFBP-3 increases.
Positive_regulation (increases) of IGFBP-3 in pole
7) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721283 Disease Relevance 0.34 Pain Relevance 0.12
No significant differences were observed among any of the 3 patient groups and control subjects in the mean concentration of either IGF-I or IGFBP-3.
Positive_regulation (concentration) of IGFBP-3
8) Confidence 0.09 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730136 Disease Relevance 0.15 Pain Relevance 0
CONCLUSIONS: This study confirmed several previously reported urine alterations in interstitial cystitis, including increased anti-proliferative factor, epidermal growth factor, IGF binding protein-3 and IL-6, and decreased heparin-binding epidermal growth factor-like growth factor and cyclic guanosine monophosphate.
Positive_regulation (increased) of IGF binding protein-3 in urine
9) Confidence 0.03 Published 2002 Journal J. Urol. Section Body Doc Link 11992058 Disease Relevance 0 Pain Relevance 0

General Comments

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