INT63365

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 12.90
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Spg21) nucleus (Spg21) biological_process (Spg21)
cytoplasm (Spg21)
Anatomy Link Frequency
mast cell 16
urine 2
embryo 1
cleavage 1
connective tissue 1
Spg21 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 200 100.00 Very High Very High Very High
Nerve growth factor 41 100.00 Very High Very High Very High
Inflammation 708 99.74 Very High Very High Very High
Chronic pancreatitis 165 99.32 Very High Very High Very High
Pain 168 98.92 Very High Very High Very High
fibrosis 15 94.08 High High
Neuropeptide 56 84.96 Quite High
antagonist 16 79.24 Quite High
agonist 20 78.88 Quite High
substance P 106 78.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 824 99.74 Very High Very High Very High
Hypersensitivity 48 99.48 Very High Very High Very High
Pancreatitis 210 99.32 Very High Very High Very High
Pain 117 98.92 Very High Very High Very High
Cystitis 60 98.04 Very High Very High Very High
Bladder Cancer 12 97.84 Very High Very High Very High
Bladder Disease 3 97.76 Very High Very High Very High
Frailty 3 97.00 Very High Very High Very High
Inflammatory Bowel Disease 106 96.68 Very High Very High Very High
Cancer 41 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serine proteases such as thrombin, trypsin and mast cell tryptase can act on different cell types through protease-activated receptors (PARs).
Gene_expression (proteases) of mast in mast cell
1) Confidence 0.65 Published 2009 Journal Pain Section Abstract Doc Link 19674841 Disease Relevance 0.38 Pain Relevance 0.32
Mast cell degranulation was determined histologically and by measurement of tissue and serum levels of rat mast cell protease-II, a mediator specific to mucosal mast cells.
Gene_expression (levels) of mast in mast cells
2) Confidence 0.58 Published 1996 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 8730246 Disease Relevance 0.16 Pain Relevance 0
Significantly more mast cells were present in WT mice with chronic pancreatitis, adding to the validity of this model for use in studies on the role of mast cells in pancreatitis.
Gene_expression (present) of mast in mast cells associated with pancreatitis and chronic pancreatitis
3) Confidence 0.13 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 1.77 Pain Relevance 1.47
Similarly, other mast cell degranulation products such as tryptase and histamine are capable of modulating neuronal function [27-32].
Gene_expression (products) of mast in mast cell
4) Confidence 0.10 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 0.93 Pain Relevance 0.67
As to be expected, no mast cells were present in pancreas of MCDM.


Gene_expression (present) of mast in mast cells
5) Confidence 0.10 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 1.20 Pain Relevance 1.11
The presence of mast cells or the mast cell-produced proteinase Mcpt4 (chymase) was recently shown to enhance the permeability of jejunal segments studied ex vivo [8].
Gene_expression (produced) of mast in mast cell
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923184 Disease Relevance 0.49 Pain Relevance 0.21
IL-10-deficient mast cells produced more pro-inflammatory cytokines in vitro both constitutively and when triggered, compared with wild type mast cells.
Gene_expression (deficient) of mast in mast cells associated with inflammation and cytokine
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923184 Disease Relevance 1.21 Pain Relevance 0.32
A second possible mechanism is that IL-33 and ST2 are required to enhance mast cell production of TNF, or other mediators, and IL-33 does enhance mast cell production of TNF [38].
Gene_expression (production) of mast in mast cell
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.40 Pain Relevance 0.12
We then investigated if mast cell-expressed IL-33 had undergone cleavage or not.
Gene_expression (expressed) of mast in cleavage
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.04
A second possible mechanism is that IL-33 and ST2 are required to enhance mast cell production of TNF, or other mediators, and IL-33 does enhance mast cell production of TNF [38].
Gene_expression (production) of mast in mast cell
10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.41 Pain Relevance 0.11
As a consequence of inflammation, products of mast cell degranulation, such as tryptase, can be found in the urine of both bladder cancer and cystitis patients [9].
Gene_expression (degranulation) of mast in urine associated with inflammation, bladder cancer and cystitis
11) Confidence 0.06 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.49 Pain Relevance 0.44
PARs provide an answer to the question of how mast cell products, such as tryptase, produce signals and induce bladder inflammation.
Gene_expression (products) of mast in bladder associated with inflammation
12) Confidence 0.06 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.94 Pain Relevance 0.44
IL-33 itself has been shown to be a potent inducer of mast cell cytokine production [15], [16], [17], [38], independent of Fc?
Neg (independent) Gene_expression (independent) of mast in mast cell associated with cytokine
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.09
To investigate the functional effects of mast cell-derived IL-33, we utilized neutralizing antibodies against ST2 or IL-33 and ST2?
Spec (investigate) Gene_expression (cell) of mast in mast cell
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.33 Pain Relevance 0.05
IL-33 itself has been shown to be a potent inducer of mast cell cytokine production [15], [16], [17], [38], independent of Fc?
Gene_expression (production) of mast in mast cell associated with cytokine
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.09
Mouse mast cell protease-7 is a tryptase predominantly expressed in differentiated connective tissue-type mast cells [66].
Gene_expression (expressed) of mast in connective tissue
16) Confidence 0.06 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.34 Pain Relevance 0.20
In addition, IL-9 stimulates the production of mast cell proteases and the expression of the high-affinity IgE receptor [Fc?
Gene_expression (production) of mast in mast cell
17) Confidence 0.03 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.30 Pain Relevance 0.07
As a consequence of inflammation, products of mast cell degranulation, such as tryptase, can be found in the urine of cystitis patients [15].
Gene_expression (degranulation) of mast in urine associated with inflammation and cystitis
18) Confidence 0.03 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 1.13 Pain Relevance 0.28
Mast cell proteases mcpt5 (chymase), mcpt6 and 7 (tryptases) are expressed during the development of the mouse embryo [49].
Gene_expression (expressed) of Mast in embryo
19) Confidence 0.03 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.45 Pain Relevance 0.18
Mouse mast cell protease-7 is a tryptase predominantly expressed in differentiated connective tissue-type mast cells [52].
Gene_expression (expressed) of mast in mast cells
20) Confidence 0.03 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.47 Pain Relevance 0.18

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