INT63373

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.90
Pain Relevance 7.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
bladder 2
nociceptor 2
cholinergic neurons 2
sciatic nerve 2
nerve 2
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 91 100.00 Very High Very High Very High
Pain 37 100.00 Very High Very High Very High
ischemia 6 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
dexamethasone 19 99.98 Very High Very High Very High
nociceptor 7 99.96 Very High Very High Very High
Pain threshold 3 98.02 Very High Very High Very High
allodynia 5 97.60 Very High Very High Very High
Hyperalgesia 6 97.40 Very High Very High Very High
Neuropeptide 4 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 37 100.00 Very High Very High Very High
Stroke 23 100.00 Very High Very High Very High
Death 16 100.00 Very High Very High Very High
Cv Unclassified Under Development 5 100.00 Very High Very High Very High
Diabetes Mellitus 26 99.84 Very High Very High Very High
Neuropathic Pain 22 99.32 Very High Very High Very High
Cognitive Disorder 4 99.08 Very High Very High Very High
Cold Sores 367 98.64 Very High Very High Very High
Disease 135 97.88 Very High Very High Very High
Hyperalgesia 8 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGF-beta1 increased expression and synthesis of both fibronectin and nerve growth factor (NGF), whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression.
Negative_regulation (inhibited) of Gene_expression (expression) of NGF in nerve associated with nerve growth factor and dexamethasone
1) Confidence 0.57 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.16 Pain Relevance 0.70
In the older GK rats, both mRNA and protein expression of nerve growth factor (NGF) in the sciatic nerve were significantly reduced (p < 0.001 and p < 0.05), and NGFR TrkA (high affinity NGF receptor) and NGFRp75 (low affinity NGF-receptor) protein expression was reduced in dorsal root ganglia (DRG) (both p < 0.05).
Negative_regulation (reduced) of Gene_expression (expression) of NGF in sciatic nerve
2) Confidence 0.57 Published 2002 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 12469361 Disease Relevance 0 Pain Relevance 0
While NGF levels are acutely reduced in injured nerve trunks, neuropathic patients with chronic skin hyperalgesia and allodynia show marked local increases of NGF levels; here anti-NGF agents may provide analgesia.
Negative_regulation (reduced) of Gene_expression (levels) of NGF in skin associated with hyperalgesia, allodynia, nerve growth factor, neuropathic pain and analgesia
3) Confidence 0.43 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.15 Pain Relevance 1.28
Behavioural and electrophysiological studies have shown that sequestration of constitutively produced NGF leads to decrease nociceptor sensitivity. 2.
Negative_regulation (decrease) of Gene_expression (produced) of NGF in nociceptor associated with nerve growth factor and nociceptor
4) Confidence 0.43 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.65 Pain Relevance 0.89
By contrast, heat-pain threshold (HP 0.5, p = 0.003) and an intermediate level of heat-pain (HP 5.0, p < 0.001) were significantly lowered 1, 3, and 7 days (and in some cases at 3 hours and 14 and 21 days) after NGF injection.
Negative_regulation (lowered) of Gene_expression (injection) of NGF associated with pain, pain threshold and nerve growth factor
5) Confidence 0.43 Published 1997 Journal Neurology Section Abstract Doc Link 9040746 Disease Relevance 1.19 Pain Relevance 1.44
The application of both TGF-beta1 and dexamethasone resulted in an additional effect on fibronectin; however, dexamethasone inhibited the TGF-beta1-induced NGF expression.
Negative_regulation (inhibited) of Gene_expression (expression) of NGF associated with nerve growth factor and dexamethasone
6) Confidence 0.42 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.15 Pain Relevance 0.72
Pain-related differential expression of NGF, GDNF, IL-6, and their receptors in human vasculitic neuropathies.
Negative_regulation (Pain-related) of Gene_expression (expression) of NGF associated with pain
7) Confidence 0.41 Published 2003 Journal Intern. Med. Section Title Doc Link 14686749 Disease Relevance 0.20 Pain Relevance 0.45
Interestingly, there was a 5-fold decrease in NGF expression in hMNP when compared to hFibs (Fig.
Negative_regulation (decrease) of Gene_expression (expression) of NGF associated with nerve growth factor
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0 Pain Relevance 0.18
Moreover, in a model of diabetic cystopathy, HSV vector-mediated NGF gene therapy has been proved useful to restore decreased NGF expression in the bladder and bladder afferent pathways, thereby improving hypoactive bladder function in diabetes [62].
Negative_regulation (decreased) of Gene_expression (expression) of NGF in bladder associated with cold sores, nerve growth factor, diabetes mellitus and overactive bladder
9) Confidence 0.28 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.40 Pain Relevance 0.51
Additional studies have also established the expression of NGF in native nucleus pulposus (NP) and AF cells which increases after stimulation with proinflammatory cytokines which have been identified in IVD degeneration [17].
Negative_regulation (established) of Gene_expression (expression) of NGF in IVD associated with nerve growth factor and cytokine
10) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.34 Pain Relevance 0.51
A recent study has also reported that transplanted porcine choroids plexus in microcapsules improved behavioral performance and decreased the pathological lesion size in rat ischemia stroke model by producing several trophic factors including NGF, BDNF and GDNF [82].
Negative_regulation (decreased) of Gene_expression (producing) of NGF in choroids associated with stroke and ischemia
11) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.63 Pain Relevance 0.13
Via exercise induced nerve growth factor production, the death of cholinergic neurons could be prevented and perhaps attenuate cognitive decline (Scott and Crutcher, 1994).
Negative_regulation (prevented) of Gene_expression (production) of nerve growth factor in cholinergic neurons associated with cognitive disorder, nerve growth factor and death
12) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2917219 Disease Relevance 1.58 Pain Relevance 0.05
Levels of BDNF in BAL fluid were not increased and levels of NGF were undetectable.
Negative_regulation (undetectable) of Gene_expression (levels) of NGF
13) Confidence 0.24 Published 2009 Journal Respir Res Section Body Doc Link PMC2688489 Disease Relevance 0.63 Pain Relevance 0
Furthermore, circulating levels of IGFs and NGF are reduced in diabetes and to a greater degree in patients with thermal sensory deficits characteristic of neuropathy [19-21].
Negative_regulation (reduced) of Gene_expression (levels) of NGF associated with nerve growth factor, diabetes mellitus and neuropathic pain
14) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1142339 Disease Relevance 0.84 Pain Relevance 0.25

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