INT63374

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.60
Pain Relevance 6.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 6
spinal 2
CSF 2
dental pulp 2
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 292 100.00 Very High Very High Very High
dexamethasone 11 100.00 Very High Very High Very High
Pain 170 99.52 Very High Very High Very High
endometriosis 168 98.40 Very High Very High Very High
substance P 77 98.10 Very High Very High Very High
Neuropeptide 46 97.88 Very High Very High Very High
Inflammation 79 97.36 Very High Very High Very High
cytokine 100 97.02 Very High Very High Very High
Lasting pain 26 95.32 Very High Very High Very High
Arthritis 3 94.60 High High
Disease Link Frequency Relevance Heat
Pain 185 99.20 Very High Very High Very High
Nociception 39 99.20 Very High Very High Very High
Injury 15 98.60 Very High Very High Very High
Endometriosis 224 98.40 Very High Very High Very High
INFLAMMATION 87 97.36 Very High Very High Very High
Intraoperative Complications 1 97.08 Very High Very High Very High
Arthritis 4 94.60 High High
Intervertebral Disk Degeneration 16 94.40 High High
Cystitis 1 94.16 High High
Headache 1 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prostate is one of the most abundant sources of nerve growth factor (NGF) in different species, including humans.
Regulation (one) of Gene_expression (sources) of NGF in nerve associated with nerve growth factor
1) Confidence 0.45 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.40 Pain Relevance 0.29
The prostate is one of the most abundant sources of nerve growth factor (NGF) in different species, including humans.
Regulation (one) of Gene_expression (sources) of nerve growth factor in nerve associated with nerve growth factor
2) Confidence 0.45 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.40 Pain Relevance 0.29
The endogenous production of NGF regulates the sensitivity of nociceptive systems.
Regulation (regulates) of Gene_expression (production) of NGF associated with nociception and nerve growth factor
3) Confidence 0.45 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.57 Pain Relevance 0.76
DISCUSSION: We did not detect any difference between patients with neuropathic versus nociceptive pain and nonpainful controls for spinal CNTF, BDNF, and NGF levels.
Neg (not) Regulation (controls) of Gene_expression (levels) of NGF in spinal
4) Confidence 0.45 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.22 Pain Relevance 0
RESULTS: The CSF concentrations of CNTF, BDNF, and NGF did not differ between the 3 patient cohorts.
Neg (not) Regulation (differ) of Gene_expression (concentrations) of NGF in CSF
5) Confidence 0.45 Published 2009 Journal Clin J Pain Section Body Doc Link 19920725 Disease Relevance 0.26 Pain Relevance 0
Using immunohistochemistry we have therefore investigated NGF and BDNF expression, including expression of the receptors Trk-A and Trk-B, in non-degenerate, moderately degenerate and severely degenerate human IVD tissue, and we have examined the effects of IL-1?
Spec (investigated) Regulation (investigated) of Spec (investigated) Gene_expression (expression) of NGF associated with nerve growth factor
6) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.16 Pain Relevance 0.34
Vice versa, pro-inflammatory cytokines may induce the expression of neuropeptides such as SP and NGF and their cognate receptors [167, 168], which might provide an explanation for the up-regulation of NGF expression in inflamed areas, e.g., in peritoneal endometriosis [121].
Regulation (regulation) of Gene_expression (expression) of NGF associated with endometriosis, nerve growth factor, inflammation, neuropeptide, substance p and cytokine
7) Confidence 0.31 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.56 Pain Relevance 1.69
ELISA assay for in vitro production of human NGF and BDNF
Regulation (assay) of Gene_expression (production) of NGF
8) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0 Pain Relevance 0
Different roles of dexamethasone on transforming growth factor-beta1-induced fibronectin and nerve growth factor expression in dental pulp cells.
Regulation (roles) of Gene_expression (expression) of nerve growth factor in dental pulp associated with nerve growth factor and dexamethasone
9) Confidence 0.27 Published 2007 Journal J Endod Section Title Doc Link 17931932 Disease Relevance 0.19 Pain Relevance 0.61
had little effect on the relative gene expression of NGF in non-degenerate and degenerate NP cells.
Neg (little) Regulation (effect) of Gene_expression (expression) of NGF associated with nerve growth factor
10) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.05 Pain Relevance 0.33
Indeed a number of studies have demonstrated regulation of NGF expression and NGF-associated pain processes by IL-1?
Regulation (regulation) of Gene_expression (expression) of NGF associated with pain and nerve growth factor
11) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.44 Pain Relevance 0.46
Additional studies investigating innervation in the degenerate IVD have also demonstrated expression of Trk-A, the high-affinity receptor for nerve growth factor (NGF), on ingrowing nerves – indicating that such nerves are NGF sensitive [4].
Regulation (sensitive) of Gene_expression (expression) of nerve growth factor in nerves associated with nerve growth factor
12) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.28 Pain Relevance 0.52
Increased expression and release of NGF have been demonstrated in several painful conditions in animal models (for example, UV injury, surgical injury) [146,147] and in human conditions, including arthritis, cystitis, prostitis and headache [148-150].
Regulation (demonstrated) of Gene_expression (expression) of NGF associated with pain, nerve growth factor, injury, cystitis, headache, intraoperative complications and arthritis
13) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.08 Pain Relevance 1.11

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