INT63375

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.17
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
neurons 2
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 119 100.00 Very High Very High Very High
Peripheral sensitization 1 99.64 Very High Very High Very High
nociceptor 4 98.52 Very High Very High Very High
backache 6 98.24 Very High Very High Very High
central sensitization 1 97.88 Very High Very High Very High
Dorsal horn neuron 1 96.88 Very High Very High Very High
Inflammation 3 91.00 High High
Hyperalgesia 2 89.32 High High
substance P 27 77.40 Quite High
Neuropeptide 21 76.60 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 10 98.40 Very High Very High Very High
Congenital Anomalies 1 96.96 Very High Very High Very High
INFLAMMATION 3 91.00 High High
Hyperalgesia 2 89.32 High High
Inflammatory Pain 3 75.00 Quite High
Nociception 14 73.88 Quite High
Osteoarthritis 6 63.60 Quite High
Pain 23 52.64 Quite High
Disease 20 49.68 Quite Low
Intervertebral Disk Degeneration 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether both NGF and BDNF are upregulated in the degenerate IVD, and as such play a key role in innervation and the pathogenesis of low back pain, however, remains to be determined.
Positive_regulation (role) of Positive_regulation (upregulated) of NGF associated with low back pain, nerve growth factor and backache
1) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.22 Pain Relevance 0.45
Whether both NGF and BDNF are upregulated in the degenerate IVD, and as such play a key role in innervation and the pathogenesis of low back pain, however, remains to be determined.
Positive_regulation (upregulated) of Positive_regulation (upregulated) of NGF associated with low back pain, nerve growth factor and backache
2) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.21 Pain Relevance 0.45
In particular, evidence is reviewed which suggests that increased NGF levels leads to both peripheral sensitization of nociceptors and central sensitization of dorsal horn neurons responding to noxious stimuli.
Positive_regulation (leads) of Positive_regulation (increased) of NGF in neurons associated with central sensitization, nerve growth factor, nociceptor, peripheral sensitization and dorsal horn neuron
3) Confidence 0.47 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730782 Disease Relevance 0.74 Pain Relevance 1.18

General Comments

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