INT6339

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Context Info
Confidence 0.14
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.71
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Anatomy Link Frequency
nerve 1
brain 1
ear 1
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 48 100.00 Very High Very High Very High
Enkephalin 3 99.96 Very High Very High Very High
Dynorphin 43 99.42 Very High Very High Very High
Morphine 30 99.32 Very High Very High Very High
gABA 4 99.28 Very High Very High Very High
antagonist 19 99.16 Very High Very High Very High
Clonidine 1 98.20 Very High Very High Very High
tail-flick 19 97.96 Very High Very High Very High
Catecholamine 1 97.76 Very High Very High Very High
Somatostatin 17 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 33 99.48 Very High Very High Very High
Obesity 7 88.96 High High
Hyperphagia 1 88.48 High High
Body Weight 3 75.00 Quite High
Targeted Disruption 12 71.12 Quite High
Hyperalgesia 4 62.32 Quite High
INFLAMMATION 34 60.72 Quite High
Pain 28 53.68 Quite High
Lifespan 33 50.00 Quite Low
Aging 15 7.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early lack of GHRH in ME, as observed here, may be due to less GHRH neurons, fewer nerve endings, or diminished GHRH.
Negative_regulation (lack) of ME in nerve
1) Confidence 0.14 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.24
A 4-hr pretreatment with the irreversible mu receptor antagonist beta-funaltrexamine (0.01-0.4 nmol i.t.) blocked [D-Ala2, N-Me-Phe4, Gly5-ol]enkephalin but not [D-Pen2,5]enkephalin or calcium (i.t.)
Negative_regulation (blocked) of N-Me-Phe4 associated with antagonist and enkephalin
2) Confidence 0.13 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1326632 Disease Relevance 0 Pain Relevance 0.82
Dynorphin (Dyn) and methionine-enkephalin (ME) levels were also decreased.
Negative_regulation (decreased) of ME associated with dynorphin and enkephalin
3) Confidence 0.08 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893279 Disease Relevance 0.25 Pain Relevance 0.52
The selective action of Bestatin might indicate the regional differences of ME catabolism in the brain and also differences in the contribution of APN to the inactivation of ME and LE.
Negative_regulation (inactivation) of ME in brain
4) Confidence 0.07 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.24 Pain Relevance 0.43
Preparation of control ME mix for ear edema experiments
Negative_regulation (Preparation) of ME in ear associated with pressure and volume under development
5) Confidence 0.06 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.16 Pain Relevance 0.03
When LE or ME administered by i.c.v. together with the peptidase inhibitors, Bestatin and Thiorphan, the antinociceptive effects were significantly reversed by a selective DOR1 antagonist but not by a selective DOR2 antagonist.
Negative_regulation (reversed) of ME associated with antagonist and antinociceptive
6) Confidence 0.05 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.05 Pain Relevance 0.72
The inhibitory effects of E and mE but not those of GABA were antagonized by iontophoretic applications of the preferential alpha 2-antagonists piperoxane and yohimbine, but not by the alpha 1-antagonist prazosin or the beta-antagonist sotalol when similarly applied.
Negative_regulation (effects) of mE associated with gaba and antagonist
7) Confidence 0.00 Published 1982 Journal Brain Res. Section Abstract Doc Link 6329415 Disease Relevance 0 Pain Relevance 0.67

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