INT63392

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Context Info
Confidence 0.46
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.73
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd5) signal transducer activity (Drd5)
Anatomy Link Frequency
blood 1
neurons 1
lymphocytes 1
Drd5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 218 100.00 Very High Very High Very High
Migraine 4 97.52 Very High Very High Very High
dopamine receptor 62 96.52 Very High Very High Very High
cocaine 210 96.48 Very High Very High Very High
antagonist 24 95.80 Very High Very High Very High
agonist 48 94.96 High High
adenocard 6 90.72 High High
addiction 14 86.88 High High
drug abuse 2 78.00 Quite High
long-term potentiation 2 68.08 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 22 99.88 Very High Very High Very High
Headache 4 97.52 Very High Very High Very High
Hypersensitivity 2 97.52 Very High Very High Very High
Parkinson's Disease 42 94.52 High High
Drug Dependence 4 87.28 High High
Muscle Rigidity 2 81.72 Quite High
Disease 46 74.40 Quite High
Attention Deficit Hyperactivity Disorder 8 12.52 Low Low
Cocaine Dependence 20 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased density of dopamine D5 receptor in peripheral blood lymphocytes may reflect the dopaminergic hypersensitivity displayed by migraineurs and may represent a relatively simple and reliable peripheral marker of altered dopaminergic function.
Positive_regulation (increased) of dopamine D5 receptor in lymphocytes associated with dopamine and hypersensitivity
1) Confidence 0.46 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8731424 Disease Relevance 0.25 Pain Relevance 0.45
Increased density of dopamine D5 receptor in peripheral blood lymphocytes of migraineurs: a marker for migraine?
Positive_regulation (Increased) of dopamine D5 receptor in blood associated with dopamine and migraine
2) Confidence 0.46 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 8731424 Disease Relevance 0.26 Pain Relevance 0.48
Persistent reductions in levels of CD47 and Arc, and inductions in levels of Drd5 and NPY suggest altered synaptic plasticity process involved in memory formation and removal of old memory traces, respectively [50,57,58].
Positive_regulation (inductions) of Drd5 associated with aids-related complex
3) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.18 Pain Relevance 0.16
Increased Drd5, and signaling through this receptor, have been reported to decrease responsiveness to cocaine [32,33].
Positive_regulation (Increased) of Drd5 associated with cocaine
4) Confidence 0.30 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.31 Pain Relevance 0.37
The contribution of D5-receptor activation to neuronal bursting in the STN has been exploited in recent experiments in which the dopamine receptor antagonist flupenthixol reduced bursting activities of STN neurons in the dopamine-depleted state, presumably through actions on constitutively active D5-receptors (Chetrit et al., 2010).
Positive_regulation (activation) of D5-receptor in neurons associated with dopamine, antagonist and dopamine receptor
5) Confidence 0.07 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.33 Pain Relevance 0.33
As D5-receptors are constitutively active, even in the absence of dopamine (Tiberi and Caron, 1994; Demchyshyn et al., 2000), D5-receptor activation in the dopamine-depleted state may contribute to the development of burst discharges in the STN (Baufreton et al., 2005b), a feature of parkinsonism in monkeys (Bergman et al., 1994) and humans (Hutchison et al., 1998).
Positive_regulation (activation) of D5-receptor associated with parkinson's disease and dopamine
6) Confidence 0.07 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.41 Pain Relevance 0.28

General Comments

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