INT63393

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd5) signal transducer activity (Drd5)
Anatomy Link Frequency
blood 4
prefrontal 2
Drd5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 47 100.00 Very High Very High Very High
Migraine 4 97.52 Very High Very High Very High
antagonist 4 86.24 High High
gABA 16 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 220 99.46 Very High Very High Very High
Headache 4 97.52 Very High Very High Very High
Stress 14 66.48 Quite High
Hypersensitivity 2 65.24 Quite High
Congenital Anomalies 44 61.28 Quite High
Urological Neuroanatomy 4 46.08 Quite Low
Galactorrhea 4 24.48 Low Low
Disease 26 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased density of dopamine D5 receptor in peripheral blood lymphocytes of migraineurs: a marker for migraine?
Positive_regulation (density) of Gene_expression (density) of dopamine D5 receptor in blood associated with dopamine and migraine
1) Confidence 0.49 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 8731424 Disease Relevance 0.26 Pain Relevance 0.48
Increased density of dopamine D5 receptor in peripheral blood lymphocytes of migraineurs: a marker for migraine?
Positive_regulation (Increased) of Gene_expression (density) of dopamine D5 receptor in blood associated with dopamine and migraine
2) Confidence 0.49 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 8731424 Disease Relevance 0.26 Pain Relevance 0.48
For example, estrogen or estrogen plus PG protects against 8-hydroxy-2-dipropylaminotetralin–induced disruption of prepulse inhibition of acoustic startle, an animal model of schizophrenia.20 Estrogen and PG also restore TH innervation following reductions in fiber density in the dorsolateral prefrontal cortex in ovariectomized female macaque monkeys,141 and subtle “miswirings” of TH-immunoreactive varicose fibers in the cingulate gyrus have been reported in schizophrenia.142 PG with estrogen also augments DA D5 receptor expression in certain hypothalamic neurons.143 D5 receptors are D1 like, and decreases in D1-like receptors are associated with schizophrenia.143
Positive_regulation (augments) of Gene_expression (expression) of DA D5 receptor in prefrontal associated with dopamine and schizophrenia
3) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.70 Pain Relevance 0.05

General Comments

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