INT63394

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Context Info
Confidence 0.76
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.85
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd5) signal transducer activity (Drd5)
Anatomy Link Frequency
blood 2
neuronal 1
prefrontal 1
Drd5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 150 100.00 Very High Very High Very High
Migraine 4 97.76 Very High Very High Very High
cocaine 315 97.32 Very High Very High Very High
withdrawal 7 96.72 Very High Very High Very High
antagonist 15 90.64 High High
drug abuse 3 84.60 Quite High
dopamine receptor 35 84.40 Quite High
adenocard 9 81.76 Quite High
addiction 17 77.92 Quite High
Neuropeptide 10 61.60 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 33 100.00 Very High Very High Very High
Schizophrenia 220 99.28 Very High Very High Very High
Headache 4 97.76 Very High Very High Very High
Drug Dependence 6 84.60 Quite High
Stress 17 66.12 Quite High
Hypersensitivity 2 65.24 Quite High
Congenital Anomalies 46 61.28 Quite High
Urological Neuroanatomy 6 45.72 Quite Low
Attention Deficit Hyperactivity Disorder 16 45.32 Quite Low
Galactorrhea 4 24.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of dopamine D5 receptor was investigated in peripheral blood lymphocytes of 11 migraine patients and of ten healthy control subjects using a radioligand binding technique with [3H]SCH 23390 as a ligand. [3H]SCH 23390 is a benzazepine derivative with potent antagonist properties at the dopamine D1-like receptors. [3H]SCH 23390 was specifically bound to peripheral blood lymphocytes of migraineurs and control subjects in a manner consistent with the labelling of a dopamine D5 receptor.
Gene_expression (expression) of dopamine D5 receptor in blood associated with dopamine, antagonist and migraine
1) Confidence 0.76 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8731424 Disease Relevance 0.17 Pain Relevance 0.42
Increased density of dopamine D5 receptor in peripheral blood lymphocytes of migraineurs: a marker for migraine?
Gene_expression (density) of dopamine D5 receptor in blood associated with dopamine and migraine
2) Confidence 0.66 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 8731424 Disease Relevance 0.26 Pain Relevance 0.48
Altered gene expression of Adora2b, Arc, CART, Cd47, Drd5, Egr1, Fos, Nefl, NPY, and Nr4a1 were confirmed by qPCR.
Gene_expression (expression) of Drd5 associated with aids-related complex
3) Confidence 0.57 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.27 Pain Relevance 0.45
The changes in Drd5, Adora2b, CD47 and CART expression may indicate a decrease in intracellular Ca2+ signaling that occurs with cocaine self-administration and persists into periods of abstinence [40,52,55,56].
Gene_expression (expression) of Drd5 associated with cocaine
4) Confidence 0.49 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.13 Pain Relevance 0.28
This work identified altered expression of two G-protein coupled receptors (GPCRs; Adora2b, Drd5), a cell-surface signaling molecule (CD47), and a component of the neuronal cytoskeleton (Nefl).
Gene_expression (expression) of Drd5 in neuronal
5) Confidence 0.44 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.32 Pain Relevance 0.36
Postsynaptic D5-receptor protein expression has been identified at the light and electron microscope level in rats and monkeys (Ciliax et al., 2000; Baufreton et al., 2003; Rommelfanger et al., 2010).


Gene_expression (expression) of D5-receptor
6) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.25
For example, estrogen or estrogen plus PG protects against 8-hydroxy-2-dipropylaminotetralin–induced disruption of prepulse inhibition of acoustic startle, an animal model of schizophrenia.20 Estrogen and PG also restore TH innervation following reductions in fiber density in the dorsolateral prefrontal cortex in ovariectomized female macaque monkeys,141 and subtle “miswirings” of TH-immunoreactive varicose fibers in the cingulate gyrus have been reported in schizophrenia.142 PG with estrogen also augments DA D5 receptor expression in certain hypothalamic neurons.143 D5 receptors are D1 like, and decreases in D1-like receptors are associated with schizophrenia.143
Gene_expression (expression) of DA D5 receptor in prefrontal associated with dopamine and schizophrenia
7) Confidence 0.03 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.70 Pain Relevance 0.05

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