INT63395

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.26
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 4
neuronal 3
parenchymal cells 2
immune cells 1
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 42 100.00 Very High Very High Very High
qutenza 34 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Inflammation 4 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
Spinal cord 6 99.84 Very High Very High Very High
antagonist 5 99.26 Very High Very High Very High
neuropeptide release 1 91.20 High High
Opioid 3 88.20 High High
Disease Link Frequency Relevance Heat
Nociception 6 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
INFLAMMATION 3 100.00 Very High Very High Very High
Wound Healing 5 98.98 Very High Very High Very High
Edema 6 91.96 High High
Injury 10 88.72 High High
Death 4 75.00 Quite High
Apoptosis 6 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with the selective NK-1R antagonist LY306,740 was used to determine the role of NK-1R activation in the regulation of nociception-induced NK-1R mRNA levels.
Spec (determine) Regulation (role) of Regulation (regulation) of NK-1R mRNA associated with nociception and antagonist
1) Confidence 0.45 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8913350 Disease Relevance 0.32 Pain Relevance 0.26
Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells.
Regulation (dependent) of Regulation (regulation) of NK-1R in neuronal associated with qutenza and substance p
2) Confidence 0.45 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15067207 Disease Relevance 0.19 Pain Relevance 1.14
Morphine application altered neurokinin-1 and neurokinin-2 receptor expression in inflammatory and parenchymal cells essential for wound healing in a cell-specific manner, demonstrating a direct effect of morphine on neurokinin receptor regulation within an array of cells involved in wound healing.
Regulation (effect) of Regulation (regulation) of neurokinin receptor in parenchymal cells associated with inflammation, wound healing and morphine
3) Confidence 0.26 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19428329 Disease Relevance 1.03 Pain Relevance 1.27
Effect of 5-HT on pain modulation of substance P in spinal cord of rats.
Regulation (Effect) of Regulation (modulation) of substance P in spinal cord associated with pain, spinal cord and substance p
4) Confidence 0.24 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 8732045 Disease Relevance 0.10 Pain Relevance 0.44
AIM: To study the effect of serotonin (5-HT) on pain modulation of substance P (SP) in spinal cord of rats.
Regulation (effect) of Regulation (modulation) of substance P in spinal cord associated with pain, serotonin, spinal cord and substance p
5) Confidence 0.24 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 8732045 Disease Relevance 0.17 Pain Relevance 0.40
Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells.
Regulation (dependent) of in immune cells Regulation (regulation) of NK-1R in neuronal associated with qutenza and substance p
6) Confidence 0.15 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15067207 Disease Relevance 0.19 Pain Relevance 1.14
Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.
Regulation (Influence) of Regulation (effects) of substance P associated with qutenza, inflammation and substance p
7) Confidence 0.09 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8938667 Disease Relevance 0.25 Pain Relevance 0.75

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