INT63401

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Context Info
Confidence 0.72
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 18.66
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
plasma 4
T cell 3
thymocyte 2
PBMC 2
mast cells 2
Il5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 106 100.00 Very High Very High Very High
Inflammation 82 100.00 Very High Very High Very High
antagonist 10 100.00 Very High Very High Very High
Inflammatory mediators 6 100.00 Very High Very High Very High
Migraine 23 99.72 Very High Very High Very High
chemokine 27 98.72 Very High Very High Very High
Sumatriptan 3 98.30 Very High Very High Very High
ischemia 68 96.44 Very High Very High Very High
Inflammatory response 20 95.36 Very High Very High Very High
lidocaine 20 91.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 112 100.00 Very High Very High Very High
Nasal Polyps 69 99.84 Very High Very High Very High
Rhinitis 21 99.76 Very High Very High Very High
Headache 17 99.72 Very High Very High Very High
Sepsis 8 99.66 Very High Very High Very High
Gastritis 35 99.54 Very High Very High Very High
Hypersensitivity 35 99.54 Very High Very High Very High
Eosinophilia 15 99.16 Very High Very High Very High
Middle Cerebral Artery Infarction 49 99.08 Very High Very High Very High
Migraine Without Aura 7 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no consistent association between the presence of eosinophils and either IL-5 or eotaxin in smooth muscle cells, suggesting that mechanisms other than IL-5 or eotaxin production may account for the eosinophilia.
Gene_expression (production) of IL-5 in eosinophils associated with eosinophilia
1) Confidence 0.72 Published 2001 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 11444199 Disease Relevance 1.69 Pain Relevance 0.12
It may work by interfering with the immunological function of type 2 T-helper cells, including IL-5 production responsible for the growth and differentiation of eosinophils.
Gene_expression (production) of IL-5 in T-helper cells
2) Confidence 0.43 Published 1996 Journal Br. J. Dermatol. Section Abstract Doc Link 8733389 Disease Relevance 0.37 Pain Relevance 0.09
IMMC is an enriched source of inflammatory mediators such as histamine, prostaglandin D2, leukotriene, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-16, TNF-?
Gene_expression (source) of IL-5 associated with inflammatory mediators
3) Confidence 0.26 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 1.64 Pain Relevance 0.52
Gene expression of various neurotrophic factors (GDNF, BDNF, VEGF and BMP7) and anti-inflammatory cytokines (IL4 and IL5) was up-regulated in transplanted HMO6 cells of brain tissue compared with those in culture.
Gene_expression (expression) of IL5 in brain associated with inflammation and cytokine
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909196 Disease Relevance 0.97 Pain Relevance 0.24
and IL2 and type 2 (Th2) produces IL4, IL5, IL9, IL10 and IL13.
Gene_expression (produces) of IL5
5) Confidence 0.20 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.67 Pain Relevance 0.43
Interleukine-5 (IL-5) has found to be significantly raised in NP compared with healthy controls and the concentration of IL-5 was independent of the atopic status of the patient (Bachert et al 2001).
Gene_expression (raised) of IL-5 associated with nasal polyps
6) Confidence 0.19 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504067 Disease Relevance 1.37 Pain Relevance 0
Vacuole density was linked to the expression of wee1 tyrosine kinase (D31838) and a nuclear co-repressor (AF059311) as well as IL-5 and -12 (AJ011299 and AF083329), all involved in cell-cycle regulation and signaling.
Gene_expression (expression) of IL-5
7) Confidence 0.16 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.41 Pain Relevance 0.11
Interestingly, we observed low to undetectable IL-5 and IL-4 levels, whereas high IL-10 levels were seen in 52.2% of the patients.
Gene_expression (undetectable) of IL-5
8) Confidence 0.10 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.26 Pain Relevance 0.46
After treatment with sumatriptan, 10 patients showed a subsequent decrease in IL-10 and an increase in both IL-4 and IL-5 plasma levels.
Gene_expression (levels) of IL-5 in plasma associated with sumatriptan
9) Confidence 0.10 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.24 Pain Relevance 0.50
RESULTS: Stimulation with ConA increased the production of IL-5 and IFN-gamma.
Gene_expression (production) of IL-5
10) Confidence 0.09 Published 1999 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 10619341 Disease Relevance 0.07 Pain Relevance 0
On the other hand, Df stimulation increased IL-5 production only.
Gene_expression (production) of IL-5
11) Confidence 0.09 Published 1999 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 10619341 Disease Relevance 0.06 Pain Relevance 0
Plasma levels of interleukin (IL)-4, IL-5, IL-10, and interferon-gamma were measured by enzyme-linked immunosorbent assay techniques.
Gene_expression (levels) of IL-5 in Plasma
12) Confidence 0.09 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.27 Pain Relevance 0.38
Dermatophagoides farinae-induced overproduction of IL-5 was inhibited by SCG and Dex.
Gene_expression (overproduction) of IL-5
13) Confidence 0.08 Published 1999 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 10619341 Disease Relevance 0.06 Pain Relevance 0
Cytokines and migraine: increase of IL-5 and IL-4 plasma levels.
Gene_expression (levels) of IL-5 in plasma associated with migraine and cytokine
14) Confidence 0.08 Published 1998 Journal Headache Section Title Doc Link 9664752 Disease Relevance 0.37 Pain Relevance 0.62
To this end, plasma levels of IFN-gamma, IL-4, IL-5, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA) techniques.
Gene_expression (levels) of IL-5 in plasma
15) Confidence 0.07 Published 1998 Journal Headache Section Abstract Doc Link 9664752 Disease Relevance 0.34 Pain Relevance 0.52
Pathogenesis includes both immediate (immunoglobulin E degranulation of mast cells and basophiles) and delayed hypersensitivity reactions (activation of TH and IL-5 production).
Gene_expression (production) of IL-5 in mast cells associated with hypersensitivity
16) Confidence 0.05 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2830978 Disease Relevance 2.06 Pain Relevance 0.04
Effects of lidocaine on proliferative response, mRNA expression, and protein production of IL-5 and IFN-gamma by PBMCs were investigated after stimulation with Dermatophagoides farinae, purified protein derivative, and phorbol 12-myristate 13-acetate plus calcium ionophore.
Gene_expression (production) of IL-5
17) Confidence 0.05 Published 2002 Journal J. Allergy Clin. Immunol. Section Body Doc Link 11897996 Disease Relevance 0.08 Pain Relevance 0
Upon Ag stimulation, 20 out of the 24 Hp-reactive clones (83%) produced IFN-gamma, but not IL-4 or IL-5 (Th1-like), whereas 4 produced IFN-gamma, IL-4, and IL-5 (Th0-like).
Gene_expression (produced) of IL-5 associated with gastritis
18) Confidence 0.05 Published 1997 Journal J. Immunol. Section Abstract Doc Link 8993017 Disease Relevance 1.78 Pain Relevance 0.25
Upon Ag stimulation, 20 out of the 24 Hp-reactive clones (83%) produced IFN-gamma, but not IL-4 or IL-5 (Th1-like), whereas 4 produced IFN-gamma, IL-4, and IL-5 (Th0-like).
Gene_expression (produced) of IL-5 associated with gastritis
19) Confidence 0.05 Published 1997 Journal J. Immunol. Section Abstract Doc Link 8993017 Disease Relevance 1.80 Pain Relevance 0.25
In sepsis patients, IL-2, IL-5, and IL-10 productions by isolated PBMC were diminished on ConA-induced activation but not in response to PHA and anti-CD3; in CPB patients, only anti-CD3-induced IL-10 production was significantly reduced.
Gene_expression (productions) of IL-5 in PBMC associated with sepsis
20) Confidence 0.04 Published 2000 Journal Shock Section Abstract Doc Link 10718372 Disease Relevance 0.43 Pain Relevance 0.16

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