INT63418

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Context Info
Confidence 0.44
First Reported 1996
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 8
Total Number 12
Disease Relevance 3.67
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
brain 1
nucleus 1
heart 1
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 1 100.00 Very High Very High Very High
antagonist 19 99.96 Very High Very High Very High
Morphine 2 98.92 Very High Very High Very High
bradykinin 29 97.64 Very High Very High Very High
analgesia 5 97.40 Very High Very High Very High
isoflurane 10 96.52 Very High Very High Very High
halothane 6 94.96 High High
antinociception 5 92.60 High High
cerebral cortex 1 88.56 High High
medulla 10 84.44 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 47 100.00 Very High Very High Very High
Stress 21 99.08 Very High Very High Very High
Pressure And Volume Under Development 16 97.96 Very High Very High Very High
Poisoning 2 95.36 Very High Very High Very High
Chronic Renal Failure 162 94.80 High High
Cough 3 87.76 High High
Diuresis 1 80.00 Quite High
Ganglion Cysts 4 77.68 Quite High
Hypertrophy 11 75.48 Quite High
Pressure Volume 2 Under Development 8 72.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the present study was to determine the effects of an angiotensin II (AII) AT1 antagonist, losartan 10, 15, and 20 mg/kg IP, and the AII AT2 antagonist, PD 123319, 20 mg/kg IP on ethanol (EtOH) intoxication as measured by the aerial righting reflex in male rats.
Spec (determine) Regulation (effects) of AT1 associated with antagonist and poisoning
1) Confidence 0.44 Published 1996 Journal Alcohol Section Abstract Doc Link 8734844 Disease Relevance 0.10 Pain Relevance 0.25
Therefore we tested the effect of Ang II AT1-receptor antagonist losartan and [7-D-Ala]-Ang 1-7 on the renal response to exogenous Ang 1-7 in standard renal-clearance experiments in the anesthetized rat.
Regulation (effect) of AT1 associated with antagonist
2) Confidence 0.44 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9676737 Disease Relevance 0.08 Pain Relevance 0.05
Role of the AT1 Angiotensin II Subtype Receptors into the RVLM in Renal Hypertension
Regulation (Role) of AT1 associated with pressure and volume under development
3) Confidence 0.29 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 1.26 Pain Relevance 0.21
In the present study, we aimed to examine the effects of AngII AT1 receptor blockade on the expression of major renal sodium transporters (NHE3, BSC-1, and TSC) and vasopressin-regulated aquaporin-2 (AQP2) in rats with an early stage of CRF induced by 5/6 nephrectomy.
Spec (examine) Regulation (effects) of AT1 receptor associated with chronic renal failure
4) Confidence 0.26 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.24 Pain Relevance 0.14
The effect of heart failure on the AT1 receptor is down-regulation and reduced gene expression.
Regulation (effect) of AT1 receptor in heart associated with myocardial infarction
5) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.93 Pain Relevance 0.18
Participation of AT1 and AT2 receptors in the differential interaction between angiotensin II or III and alpha-2 adrenoceptors in the nucleus reticularis gigantocellularis in cardiovascular regulation and antinociception in rats.
Regulation (Participation) of AT1 in nucleus associated with antinociception
6) Confidence 0.14 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8930186 Disease Relevance 0.14 Pain Relevance 0.38
Similarly, none of the anaesthetics tested affected AT1A signalling.
Regulation (affected) of AT1A
7) Confidence 0.07 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0 Pain Relevance 0.15
To determine the site of action of the volatile anaesthetics we compared anaesthetic effects on m1, m3 and AT1A receptor function and studied the effects of volatile anaesthetics on signalling induced by intracellular injection of the second messenger IP3.
Regulation (effects) of AT1A
8) Confidence 0.07 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0.13 Pain Relevance 0.30
Angiotensin II is the main effector peptide of the RAS and acts on two main receptor subtypes: angiotensin type I (AT1); and angiotensin type II (AT2).
Regulation (acts) of angiotensin type I
9) Confidence 0.04 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.20 Pain Relevance 0
AIM: To study the regulation of monoamine oxidase-B (MAO-B) activity and imidazoline receptors (I-R) during long term treatment of morphine.
Regulation (regulation) of I-R associated with morphine and monoamine
10) Confidence 0.03 Published 2001 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11749830 Disease Relevance 0 Pain Relevance 0.22
The purpose of present study was to examine the modulation of AT1 receptor in the immobilization stress and angiotensin II (AngII)-induced analgesia and impaired retention, and to determine whether resultant behavioral changes involve common sensory signals.
Spec (examine) Regulation (modulation) of AT1 receptor associated with stress and analgesia
11) Confidence 0.02 Published 1999 Journal Peptides Section Abstract Doc Link 10447091 Disease Relevance 0.59 Pain Relevance 0.33
A1R and P2Y2R immunoreactivities were present in all three rat brain regions examined (Figure 3A, B, F).
Spec (examined) Regulation (immunoreactivities) of A1R in brain
12) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.22

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