INT63419

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 109
Total Number 110
Disease Relevance 40.83
Pain Relevance 23.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
chondrocytes 7
PGE2 6
HMSM 4
amnion 3
articular cartilage 3
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 893 100.00 Very High Very High Very High
COX2 71 100.00 Very High Very High Very High
Inflammatory mediators 40 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
melanocortin 1 receptor 8 99.88 Very High Very High Very High
cINOD 161 99.84 Very High Very High Very High
cytokine 448 99.82 Very High Very High Very High
Enkephalin 14 99.70 Very High Very High Very High
rheumatoid arthritis 33 99.48 Very High Very High Very High
Dopamine 4 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1072 100.00 Very High Very High Very High
Targeted Disruption 37 99.80 Very High Very High Very High
Glioma 2 99.56 Very High Very High Very High
Rheumatoid Arthritis 33 99.48 Very High Very High Very High
Herpes Simplex Virus 714 99.46 Very High Very High Very High
Sprains And Strains 11 99.30 Very High Very High Very High
Nociception 2 99.24 Very High Very High Very High
Atherosclerosis 26 98.84 Very High Very High Very High
Osteoarthritis 1107 98.76 Very High Very High Very High
Schizophrenia 7 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mPGES-2 mRNA increased with term labour and PTL and expression of COX-2 and mPGES-1 mRNA with term labour, whereas cPGES expression did not change.
Gene_expression (expression) of mPGES-1 mRNA
1) Confidence 0.77 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.06 Pain Relevance 0.14
We have determined (i) the immuno-localization of all three PGES enzymes in lower segment pregnant human myometrium, (ii) the expression of PGES and COX-2 mRNA expression at term and preterm gestation with and without labour and (iii) the effect of interleukin (IL)-1beta on COX-2 and PGES mRNA and protein expression in human myometrial smooth muscle (HMSM) cell cultures.
Gene_expression (expression) of PGES in HMSM
2) Confidence 0.77 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.07 Pain Relevance 0.18
We have determined (i) the immuno-localization of all three PGES enzymes in lower segment pregnant human myometrium, (ii) the expression of PGES and COX-2 mRNA expression at term and preterm gestation with and without labour and (iii) the effect of interleukin (IL)-1beta on COX-2 and PGES mRNA and protein expression in human myometrial smooth muscle (HMSM) cell cultures.
Gene_expression (expression) of PGES in HMSM
3) Confidence 0.77 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0.08 Pain Relevance 0.20
Thus, COX-2 expression and mPGES-1 expression are co-ordinately up-regulated in lower segment myometrium with term labour and with IL-1beta treatment in HMSM cells.
Gene_expression (expression) of mPGES-1 in HMSM
4) Confidence 0.77 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0 Pain Relevance 0
In inflammation and clinically relevant biological systems, mPGES-1 expression, like COX-2 expression was induced in cell context- and time-dependent manner, consistent with the kinetics of PGE(2) synthesis.
Gene_expression (expression) of mPGES-1 associated with inflammation
5) Confidence 0.76 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.58 Pain Relevance 0.39
Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour.
Gene_expression (Expression) of prostaglandin E synthase in myometrium associated with cox2
6) Confidence 0.75 Published 2007 Journal Mol. Hum. Reprod. Section Title Doc Link 17105783 Disease Relevance 0.10 Pain Relevance 0.34
It is interesting that early growth response-1 (Egr-1) protein, which is a key transcription factor in regulating the inducible expression of microsomal PGE synthase 1 (mPGES-1) and therefore promotes PGE2 release [40], is also significantly reduced by an HO-1 inducer, CoPP, in IL-1?
Gene_expression (expression) of mPGES-1
7) Confidence 0.75 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.25 Pain Relevance 0.12
Expression of the LASS4, PTGES, ZDHHC1 and ZDHHC8 transcripts involved in lipid biosynthesis, metabolism and modification were all increased.


Gene_expression (Expression) of PTGES
8) Confidence 0.75 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.23 Pain Relevance 0.07
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Gene_expression (expression) of microsomal PGE synthase-1
9) Confidence 0.75 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.57 Pain Relevance 0.21
We conclude that the inhibitory effect of ellagic acid on PGE2 release from monocytes is due to a suppressed expression of COX-2, mPGEs-1 and cPLA2alpha, rather than a direct effect on the activities of these enzymes.
Gene_expression (expression) of mPGEs-1 in monocytes
10) Confidence 0.75 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.45 Pain Relevance 0.16
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Gene_expression (expression) of mPGEs-1
11) Confidence 0.75 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.57 Pain Relevance 0.21
Alternatively activated M2 monocytes-macrophages exposed to IL-4, IL-13, or IL-10 did not express mPGES-1, whereas in these cells, IL-4, IL-13, and to a lesser extent, IL-10 or IFN-gamma inhibited LPS-induced, mPGES-1 expression.
Neg (not) Gene_expression (express) of mPGES-1 in macrophages
12) Confidence 0.74 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.49 Pain Relevance 0.35
Alternatively activated M2 monocytes-macrophages exposed to IL-4, IL-13, or IL-10 did not express mPGES-1, whereas in these cells, IL-4, IL-13, and to a lesser extent, IL-10 or IFN-gamma inhibited LPS-induced, mPGES-1 expression.
Gene_expression (expression) of mPGES-1 in macrophages
13) Confidence 0.74 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.46 Pain Relevance 0.34
Thus, activated M1, unlike alternatively activated M2, mononuclear phagocytes express mPGES-1, and IL-4, IL-13, and IL-10 tune expression of this key enzyme in prostanoid metabolism.
Gene_expression (express) of mPGES-1 in mononuclear phagocytes
14) Confidence 0.74 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.24 Pain Relevance 0.25
Exposure to LPS strongly induced mPGES-1 expression.
Gene_expression (expression) of mPGES-1
15) Confidence 0.74 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.51 Pain Relevance 0.36
The present study was designed to investigate the regulation of expression of mPGES-1 in polarized phagocytes, which represent central, cellular orchestrators of inflammatory reactions.
Gene_expression (expression) of mPGES-1 in phagocytes associated with inflammation
16) Confidence 0.74 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.56 Pain Relevance 0.32
Prostaglandin E synthase (PTGES, also known as microsomal PGE synthase-1) acts downstream of PTGS2 and is inducibly expressed in most systems.
Gene_expression (expressed) of PTGES
17) Confidence 0.72 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.18 Pain Relevance 0.27
Nuclear factor-kappa B regulates inducible prostaglandin E synthase expression in human amnion mesenchymal cells.
Gene_expression (expression) of prostaglandin E synthase in amnion associated with cytokine
18) Confidence 0.72 Published 2008 Journal Biol. Reprod. Section Title Doc Link 17928629 Disease Relevance 0.19 Pain Relevance 0.31
Prostaglandin E synthase (PTGES, also known as microsomal PGE synthase-1) acts downstream of PTGS2 and is inducibly expressed in most systems.
Gene_expression (expressed) of Prostaglandin E synthase
19) Confidence 0.72 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.18 Pain Relevance 0.27
In parallel, increased expression of the PTGS2 and PTGES proteins was observed.
Gene_expression (expression) of PTGES
20) Confidence 0.72 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.15 Pain Relevance 0.24

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