INT63422

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.11
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2B) plasma membrane (ITGA2B)
Anatomy Link Frequency
platelet 4
monocytes 2
ITGA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 1 98.72 Very High Very High Very High
diclofenac 3 98.54 Very High Very High Very High
Angina 4 96.36 Very High Very High Very High
agonist 1 89.72 High High
cINOD 1 66.72 Quite High
Disease Link Frequency Relevance Heat
Adhesions 7 97.88 Very High Very High Very High
Cv General 3 Under Development 4 96.36 Very High Very High Very High
Rupture 1 95.88 Very High Very High Very High
Coronary Artery Disease 3 95.08 Very High Very High Very High
Death 1 90.72 High High
INFLAMMATION 1 66.48 Quite High
Atherosclerotic Plaque 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low
Myocardial Infarction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrated significantly increased expression of GP53 and activated GPIIb/IIIa on the platelet surface using a sensitive flow cytometric method of detection.
Positive_regulation (increased) of Gene_expression (expression) of GPIIb in platelet
1) Confidence 0.67 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735809 Disease Relevance 0.45 Pain Relevance 0.15
Moreover, immunocytofluorimetry demonstrated that diclofenac dose-dependently (100-500 microM) induced the expression of GMP-140 and increased the expression of GPIIb/IIIa on the membrane of unstimulated platelets.
Positive_regulation (increased) of Gene_expression (expression) of GPIIb in platelets associated with diclofenac
2) Confidence 0.49 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735806 Disease Relevance 0.47 Pain Relevance 0.24
METHODS: We studied changes in adhesion molecule expression of platelets (GPIIb/IIIa), neutrophils--CD18, CD11b and L-selectin--and monocytes (CD14) after interaction with active lesions of patients with stable angina subjected to PTCA and patients with unstable angina (UA).
Positive_regulation (changes) of Gene_expression (expression) of GPIIb in monocytes
3) Confidence 0.49 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771923 Disease Relevance 0.19 Pain Relevance 0
RESULTS: CD62P and CD41/45 expressions increased significantly in UA patients to 24.36 +/- 7.91% and 29.51 +/- 12.21% respectively.
Positive_regulation (increased) of Gene_expression (expressions) of CD41
4) Confidence 0.45 Published 2002 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12584788 Disease Relevance 0 Pain Relevance 0

General Comments

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