INT63423

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Context Info
Confidence 0.55
First Reported 1996
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.98
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
platelet 14
granulocyte 2
leukocytes 2
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 83 100.00 Very High Very High Very High
Inflammation 3 93.04 High High
diclofenac 3 92.20 High High
agonist 17 84.84 Quite High
Angina 9 79.92 Quite High
Tetrahydrobiopterin 1 70.48 Quite High
cINOD 4 61.84 Quite High
anesthesia 10 50.00 Quite Low
antagonist 4 50.00 Quite Low
Analgesic 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 125 100.00 Very High Very High Very High
Heart Rate Under Development 20 99.80 Very High Very High Very High
INFLAMMATION 7 93.04 High High
Graft Vs Host Disease 2 88.04 High High
Cv General 3 Under Development 9 79.92 Quite High
Thrombosis 7 70.36 Quite High
Coronary Artery Disease 7 50.00 Quite Low
Organ Transplantation 2 29.40 Quite Low
Disorder Of Lipid Metabolism 7 26.56 Quite Low
Bacterial Respiratory Disease 1 22.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low-dose sevoflurane inhalation reduced ADP-induced CD62P expression on platelets 24 h after inhalation, and inhibited the formation of granulocyte-platelet aggregates under stimulation with AA and ADP after 1 and 24 h, and with TRAP-6 after 24 h compared with control.
Negative_regulation (reduced) of Gene_expression (expression) of CD62P in granulocyte
1) Confidence 0.55 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18499605 Disease Relevance 0 Pain Relevance 0
The direct thrombin inhibitor argatroban prevented platelet loss and expression of P-selectin significantly more than did heparin.
Negative_regulation (prevented) of Gene_expression (expression) of P-selectin in platelet
2) Confidence 0.53 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
These antagonists significantly suppressed but did not abolish P-selectin expression, annexin V binding, and microparticle formation.
Neg (not) Negative_regulation (abolish) of Gene_expression (expression) of P-selectin
3) Confidence 0.53 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
RESULTS: 4-Methylaminoantipyrine (MAA), the active metabolite of dipyrone, largely attenuated or even completely abolished the inhibition of arachidonic acid-induced platelet aggregation, thromboxane formation and P-selectin expression by aspirin.
Negative_regulation (abolished) of Gene_expression (expression) of P-selectin in platelet
4) Confidence 0.47 Published 2008 Journal J. Thromb. Haemost. Section Body Doc Link 17944992 Disease Relevance 0 Pain Relevance 0
P-selectin expression increased at 0 min in both groups, and was preserved significantly at 5 min and reduced at 120 min in group F.
Negative_regulation (reduced) of Gene_expression (expression) of P-selectin
5) Confidence 0.43 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
High doses ( > 500 microM) of this drug inhibited thrombin-stimulated expression of GPIIb/IIIa and GMP-140.
Negative_regulation (inhibited) of Gene_expression (expression) of GMP-140
6) Confidence 0.39 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735806 Disease Relevance 0.45 Pain Relevance 0.23
The direct thrombin inhibitor argatroban prevented platelet loss and expression of P-selectin significantly more than did heparin.
Negative_regulation (loss) of Gene_expression (expression) of P-selectin in platelet
7) Confidence 0.39 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
The median percentage of platelets exhibiting CD62P expression and PAC-1 binding by FC evaluation after stimulation in the presence of PG E1 was 25.4% (IQR: 21.4–33.1%) and 3.5% (1.7–9.4%), respectively.
Negative_regulation (exhibiting) of Gene_expression (expression) of CD62P in platelets associated with heart rate under development
8) Confidence 0.33 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2683811 Disease Relevance 0.34 Pain Relevance 0.11
Flow cytometry was performed for measurement of fibrinogen binding, platelet surface expression of P-selectin, and microparticles.
Negative_regulation (measurement) of Gene_expression (expression) of P-selectin in platelet
9) Confidence 0.31 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
Of the platelet aggregation inhibitors tested, only cilostazol significantly attenuated the adhesion through decreasing expression of intercellular adhesion molecule-1 (ICAM-1) and P-selectin.
Negative_regulation (decreasing) of Gene_expression (expression) of P-selectin in platelet
10) Confidence 0.27 Published 2004 Journal Microvasc. Res. Section Body Doc Link 15313121 Disease Relevance 0.16 Pain Relevance 0
Moreover, the GMP-140 level in the CSDP group was reduced significantly as compared with the control group, and to approach the level of normal (P > 0.05), while in the control group, it was higher as compared with the normal control (P < 0.05).
Negative_regulation (reduced) of Gene_expression (level) of GMP-140
11) Confidence 0.14 Published 2000 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 11789221 Disease Relevance 0.13 Pain Relevance 0
In addition to inhibition of DNA synthesis in lymphocytes, depletion of guanosine nucleotides suppresses the expression of several adhesion receptors including vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and P-selectin on vascular endothelial cells.9 This interferes with the attachment of leukocytes to endothelial cells and prevents the recruitment of lymphocytes and monocytes to sites of inflammation.10,11 Suppression of mononuclear cell recruitment is another mechanism by which MMF decreases acute and chronic graft rejection.
Negative_regulation (suppresses) of Gene_expression (expression) of P-selectin in leukocytes associated with inflammation, graft vs host disease and adhesions
12) Confidence 0.12 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.38 Pain Relevance 0.08
After in vitro activation, binding of fibrinogen and expression of P-selectin were (with the exception of ADP-induced P-selectin expression on ASA-treated platelets) consistently decreased for patients compared to the reference values (Table 1).
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin in platelets associated with aspirin
13) Confidence 0.05 Published 2009 Journal J Transl Med Section Body Doc Link PMC2699331 Disease Relevance 0.52 Pain Relevance 0.15

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