INT63425

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 15.34
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
platelets 25
polymorphonuclear leukocyte 4
leukocyte 3
macrophages 2
coronary artery 2
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 219 100.00 Very High Very High Very High
Delta-9-tetrahydrocannabinol 9 99.98 Very High Very High Very High
aspirin 84 99.84 Very High Very High Very High
diclofenac 3 99.30 Very High Very High Very High
Cannabinoid receptor 4 99.00 Very High Very High Very High
cva 57 96.00 Very High Very High Very High
Kinase C 8 95.00 High High
anesthesia 7 92.56 High High
ischemia 34 91.28 High High
agonist 19 91.24 High High
Disease Link Frequency Relevance Heat
Adhesions 370 100.00 Very High Very High Very High
INFLAMMATION 261 100.00 Very High Very High Very High
Heart Rate Under Development 23 99.80 Very High Very High Very High
Coronary Vasospasm 7 99.40 Very High Very High Very High
Pancreatitis 12 99.36 Very High Very High Very High
Stress 37 99.08 Very High Very High Very High
Nicotine Addiction 370 98.72 Very High Very High Very High
Injury 59 98.20 Very High Very High Very High
Brain Hemorrhage 64 98.00 Very High Very High Very High
Hemorrhage 8 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a recent study it was demonstrated that EDTA, used as the blood anticoagulant, brought about a significant increase in expression of GMP-140 antigen, and this effect was accompanied by a significant increase in platelet MLF.
Positive_regulation (increase) of Gene_expression (expression) of GMP-140 in platelet
1) Confidence 0.67 Published 1998 Journal Platelets Section Abstract Doc Link 16793756 Disease Relevance 0 Pain Relevance 0
These areas presented considerably increased endothelial P-selectin expression with adherent, oxygen free radical-producing polymorphonuclear leukocytes displaying pericellular cerium-reflectance.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in polymorphonuclear leukocytes
2) Confidence 0.66 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11677940 Disease Relevance 1.14 Pain Relevance 0.05
We have noted P-selectin overexpression with a preponderance in the areas of acinar oxidative stress.
Positive_regulation (overexpression) of Gene_expression (overexpression) of P-selectin associated with stress
3) Confidence 0.66 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11677940 Disease Relevance 1.01 Pain Relevance 0
Low-dose sevoflurane inhalation reduced ADP-induced CD62P expression on platelets 24 h after inhalation, and inhibited the formation of granulocyte-platelet aggregates under stimulation with AA and ADP after 1 and 24 h, and with TRAP-6 after 24 h compared with control.
Positive_regulation (induced) of Gene_expression (expression) of CD62P in granulocyte
4) Confidence 0.65 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18499605 Disease Relevance 0 Pain Relevance 0
Moreover, immunocytofluorimetry demonstrated that diclofenac dose-dependently (100-500 microM) induced the expression of GMP-140 and increased the expression of GPIIb/IIIa on the membrane of unstimulated platelets.
Positive_regulation (induced) of Gene_expression (expression) of GMP-140 in platelets associated with diclofenac
5) Confidence 0.64 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735806 Disease Relevance 0.48 Pain Relevance 0.24
P-selectin expression increased at 0 min in both groups, and was preserved significantly at 5 min and reduced at 120 min in group F.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin
6) Confidence 0.51 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
Positive_regulation (activation-dependent) of Gene_expression (expression) of P-selectin in platelets
7) Confidence 0.49 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0 Pain Relevance 0
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
Positive_regulation (activation-dependent) of Gene_expression (expression) of CD62p in platelets
8) Confidence 0.49 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0 Pain Relevance 0
One week was allowed for progression of inflammation and recruitment of macrophages, as it has been shown that inflammatory events at the endothelial layer (e.g. expression of inflammatory cell adhesion molecules E-selectin and P-selectin) begin as early as one hour after induction of the injury[24].
Positive_regulation (begin) of Gene_expression (expression) of P-selectin in macrophages associated with inflammation, injury and adhesions
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952595 Disease Relevance 0.82 Pain Relevance 0.38
Accordingly, it has been shown that P-selectin expression is generally increased on the surface of platelets in smokers, a process that requires translocation of P-selectin from the intracellular ?
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in platelets associated with nicotine addiction
10) Confidence 0.44 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.74 Pain Relevance 0.18
Accordingly, it has been shown that P-selectin expression is generally increased on the surface of platelets in smokers, a process that requires translocation of P-selectin from the intracellular ?
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in platelets associated with nicotine addiction
11) Confidence 0.44 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.74 Pain Relevance 0.18
RESULTS: AA, ADP, and TRAP-6 markedly increased the expression of CD62P on platelets, whereas CD42b (shedding) and PAC-1 (heterotypic conjugates) expression decreased.
Positive_regulation (increased) of Gene_expression (expression) of CD62P in platelets
12) Confidence 0.44 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18499605 Disease Relevance 0 Pain Relevance 0
In addition, MAFP pretreatment of tryptase-stimulated HBMEC increased both surface expression of P-selectin and polymorphonuclear leukocyte adherence to the HBMEC monolayer.
Positive_regulation (increased) of Gene_expression (expression) of P-selectin in polymorphonuclear leukocyte
13) Confidence 0.39 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15937147 Disease Relevance 0.55 Pain Relevance 0.40
THC increased the expression of glycoprotein IIb-IIIa and P selectin on human platelets in a concentration-dependent manner.
Positive_regulation (increased) of Gene_expression (expression) of P selectin in platelets associated with delta-9-tetrahydrocannabinol
14) Confidence 0.39 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385362 Disease Relevance 0.49 Pain Relevance 0.63
As expected, the median values of CD62P expression and PAC-1 binding in patients were significantly lower than in controls only in high responders (p < 0.0001) and intermediate responders (p < 0.0001 and p < 0.02, respectively).


Positive_regulation (values) of Gene_expression (expression) of CD62P associated with heart rate under development
15) Confidence 0.39 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.38 Pain Relevance 0
Flow cytometry was performed for measurement of fibrinogen binding, platelet surface expression of P-selectin, and microparticles.
Positive_regulation (performed) of Gene_expression (expression) of P-selectin in platelet
16) Confidence 0.37 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
Moreover, previous studies reported that an irregular heart rate blunted nitric oxide (NO) synthesis and increased p-selectin expression on platelets, ultimately increasing the risk for SBI [32,33].
Positive_regulation (increased) of Gene_expression (expression) of p-selectin in platelets associated with brain hemorrhage
17) Confidence 0.18 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.43 Pain Relevance 0
Circulating plasma levels of P-selectin, E-selectin, and intercellular cell adhesion molecule-1 were elevated in patients with vasospastic angina, indicating an association of endothelial damage and inflammatory reaction with coronary vasospasm.55)56) Hung et al.57) prospectively investigated the association of high-sensitivity C-reactive protein (CRP), a sensitive marker of inflammation, with coronary vasospasm and no hemodynamically significant coronary artery disease in a sample of 428 patients who underwent coronary angiography.
Spec (investigated) Positive_regulation (Circulating) of Spec (investigated) Gene_expression (levels) of P-selectin in coronary artery associated with coronary artery disease, inflammation, cva, coronary vasospasm and adhesions
18) Confidence 0.16 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 1.35 Pain Relevance 0.44
-thromboglobulin or P-selectin, sCD40L has been extensively studied in hyperglycemic subjects (8,9,21) and measured at the site of injury (19,22); ?
Positive_regulation (-) of Gene_expression (studied) of P-selectin associated with injury
19) Confidence 0.13 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.89 Pain Relevance 0
After in vitro activation, binding of fibrinogen and expression of P-selectin were (with the exception of ADP-induced P-selectin expression on ASA-treated platelets) consistently decreased for patients compared to the reference values (Table 1).
Positive_regulation (induced) of Gene_expression (expression) of P-selectin in platelets associated with aspirin
20) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2699331 Disease Relevance 0.45 Pain Relevance 0.15

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