INT63440

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Context Info
Confidence 0.39
First Reported 1996
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.53
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
PVN 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 8 100.00 Very High Very High Very High
fluoxetine 12 98.36 Very High Very High Very High
Action potential 1 96.48 Very High Very High Very High
Locus ceruleus 3 96.08 Very High Very High Very High
Endogenous opioid 1 84.00 Quite High
Neuropeptide 11 82.76 Quite High
tetrodotoxin 2 77.08 Quite High
sodium channel 1 76.24 Quite High
Opioid 1 75.00 Quite High
Intracerebroventricular 1 66.44 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 12 100.00 Very High Very High Very High
Depression 2 92.04 High High
Body Weight 2 90.00 High High
Anorexia 4 81.04 Quite High
Weight Gain 2 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The divergent effects of imipramine vs the other 3 antidepressant drugs on Arc NPY mRNA expression are similar to the pattern of changes in tyrosine hydroxylase (TH) mRNA expression levels in the locus coeruleus (LC) using the same experimental paradigm, but are different from the unidirectional depressive effects of all four drugs on CRH mRNA expression in the PVN.
Regulation (effects) of Transcription (expression) of Arc NPY in PVN associated with antidepressant, depression, aids-related complex and locus ceruleus
1) Confidence 0.39 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.68 Pain Relevance 0.66
These findings suggested that membrane depolarization regulates the NPY gene transcription positively through the unique CaMRE by activation of CaM kinases following Ca entry through L-type Ca channels.
Regulation (regulates) of Transcription (transcription) of NPY gene
2) Confidence 0.28 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8780004 Disease Relevance 0 Pain Relevance 0.16
Furthermore, our data demonstrate stimulatory action of ghrelin on NPY gene transcription, which requires de novo protein synthesis.
Regulation (action) of Transcription (transcription) of NPY gene
3) Confidence 0.27 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.27
In the pair-fed group, NPY mRNA levels did not change, but the POMC levels decreased (compared with the vehicle controls).
Neg (not) Regulation (change) of Transcription (levels) of NPY
4) Confidence 0.27 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.68 Pain Relevance 0.93
Half of the animals were given ad libitum access to food whereas the other half of the animals were food-deprived. 2-DG increased food intake fourfold compared to saline injected animals, but did not affect NPY mRNA levels after 2 h.
Neg (not) Regulation (affect) of Transcription (levels) of NPY
5) Confidence 0.26 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593862 Disease Relevance 0.18 Pain Relevance 0.24

General Comments

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