INT63441

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Context Info
Confidence 0.60
First Reported 1996
Last Reported 2004
Negated 3
Speculated 4
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 4.51
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
nucleus 10
plasma 4
hypothalamus 2
brain 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 24 99.98 Very High Very High Very High
antidepressant 16 99.84 Very High Very High Very High
corticosteroid 4 99.80 Very High Very High Very High
cocaine 11 99.44 Very High Very High Very High
withdrawal 10 99.36 Very High Very High Very High
Locus ceruleus 3 98.14 Very High Very High Very High
amygdala 5 95.44 Very High Very High Very High
Analgesic 1 95.04 Very High Very High Very High
Thalamus 4 93.80 High High
depression 3 91.40 High High
Disease Link Frequency Relevance Heat
Stress 47 100.00 Very High Very High Very High
Cystitis 8 100.00 Very High Very High Very High
Depression 4 99.98 Very High Very High Very High
Aids-related Complex 8 98.16 Very High Very High Very High
Pressure Volume 2 Under Development 4 95.52 Very High Very High Very High
Urological Neuroanatomy 2 85.72 High High
Adrenal Insufficiency 2 69.44 Quite High
Nociception 12 25.92 Quite Low
Recurrence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of cyclophosphamide (CP)-induced cystitis on the expression of corticotropin-releasing hormone (CRH) mRNA in the paraventricular nucleus (PVN) and the serum levels of adrenocorticotropic hormone (ACTH) using in situ hybridization histochemistry and radioimmunoassay.
Spec (examined) Regulation (effects) of Transcription (expression) of CRH in nucleus associated with cystitis
1) Confidence 0.60 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.25 Pain Relevance 0.04
These results suggest that corticosterone affects CRH gene transcription in the PVHmpd using two mechanisms: first, inhibition, which probably uses type II glucocorticoid receptor-dependent mechanisms and contributes to classic negative feedback; and second, facilitation, which is seen at low plasma concentrations and maintains gene transcription in the presence of sustained stress, possibly using type I mechanisms.
Regulation (affects) of Transcription (transcription) of CRH gene in plasma associated with stress
2) Confidence 0.60 Published 1998 Journal Endocrinology Section Abstract Doc Link 9724036 Disease Relevance 0.30 Pain Relevance 0
We have used in situ hybridization to investigate how basal levels of circulating corticosterone modulate CRH gene transcription in the neuroendocrine parvicellular part of the hypothalamic paraventricular nucleus (PVHmpd) during sustained hypovolemia.
Spec (investigate) Regulation (modulate) of Transcription (transcription) of CRH gene in nucleus associated with pressure volume 2 under development
3) Confidence 0.60 Published 1998 Journal Endocrinology Section Abstract Doc Link 9724036 Disease Relevance 0.16 Pain Relevance 0
We examined the effects of cyclophosphamide (CP)-induced cystitis on the expression of corticotropin-releasing hormone (CRH) mRNA in the paraventricular nucleus (PVN) and the serum levels of adrenocorticotropic hormone (ACTH) using in situ hybridization histochemistry and radioimmunoassay.
Spec (examined) Regulation (effects) of Transcription (expression) of corticotropin-releasing hormone in nucleus associated with cystitis
4) Confidence 0.44 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.25 Pain Relevance 0.04
The neurosteroid tetrahydroprogesterone (5 alpha-pregnan-3 alpha-ol-20-one, allopregnanolone, THP), has been previously shown to counteract the anxiogenic effects of corticotropin-releasing hormone (CRH) and to interfere with noradrenergic and corticosteroid-mediated regulation of CRH release and gene transcription.
Regulation (regulation) of Transcription (transcription) of CRH associated with corticosteroid
5) Confidence 0.43 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8946427 Disease Relevance 0.29 Pain Relevance 0.29
The divergent effects of imipramine vs the other 3 antidepressant drugs on Arc NPY mRNA expression are similar to the pattern of changes in tyrosine hydroxylase (TH) mRNA expression levels in the locus coeruleus (LC) using the same experimental paradigm, but are different from the unidirectional depressive effects of all four drugs on CRH mRNA expression in the PVN.
Regulation (effects) of Transcription (expression) of CRH mRNA in PVN associated with antidepressant, depression, aids-related complex and locus ceruleus
6) Confidence 0.42 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.64 Pain Relevance 0.63
The current study was proposed to further understand the effects of repeated and acute restraint stress on levels of thalamic CRH mRNA.
Regulation (effects) of Transcription (levels) of CRH associated with stress
7) Confidence 0.27 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578616 Disease Relevance 0.83 Pain Relevance 0.08
Repeated restraint did not alter baseline CRH mRNA levels, but blocked the acute restraint-induced effects.
Neg (not) Regulation (alter) of Transcription (levels) of CRH
8) Confidence 0.27 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578616 Disease Relevance 0.87 Pain Relevance 0.08
There were no changes in either plasma corticosterone or amygdalar CRH mRNA levels after 10-day cocaine withdrawal.
Neg (no) Regulation (changes) of Transcription (levels) of CRH in plasma associated with withdrawal and cocaine
9) Confidence 0.27 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782395 Disease Relevance 0.28 Pain Relevance 1.12
In addition, intron-directed in situ hybridization analysis was used to examine fluoxetine regulation of corticotropin-releasing factor heteronuclear gene transcription in the paraventricular nucleus of the hypothalamus.
Spec (examine) Regulation (regulation) of Transcription (transcription) of corticotropin-releasing factor in hypothalamus associated with fluoxetine
10) Confidence 0.21 Published 1998 Journal Neuroscience Section Abstract Doc Link 9740405 Disease Relevance 0.09 Pain Relevance 0.59
Significant changes in corticotropin-releasing factor type 1 receptor messenger RNA levels were also observed in the paraventricular nucleus but with a slow incremental biosynthesis of the receptor messenger RNA, as high levels were discernible only 360 min after fluoxetine treatment.
Regulation (changes) of Transcription (levels) of corticotropin-releasing factor in nucleus associated with fluoxetine
11) Confidence 0.21 Published 1998 Journal Neuroscience Section Abstract Doc Link 9740405 Disease Relevance 0.06 Pain Relevance 0.54
Basal CRF hnRNA and mRNA expression were not affected by antidepressant treatment in the PVN or in other brain regions examined.
Neg (not) Regulation (affected) of Transcription (expression) of CRF in brain associated with antidepressant
12) Confidence 0.13 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861819 Disease Relevance 0.50 Pain Relevance 0.49

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