INT63444

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Context Info
Confidence 0.51
First Reported 1996
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 14.65
Pain Relevance 26.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
spinal cord 8
hippocampus 5
nucleus 4
sensory systems 4
hypothalamus 4
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 418 100.00 Very High Very High Very High
Glutamate 141 100.00 Very High Very High Very High
Substantia nigra 91 100.00 Very High Very High Very High
Neurotransmitter 44 100.00 Very High Very High Very High
Morphine 43 100.00 Very High Very High Very High
antidepressant 26 100.00 Very High Very High Very High
Dynorphin 16 100.00 Very High Very High Very High
GABA receptor 13 100.00 Very High Very High Very High
Pain threshold 10 100.00 Very High Very High Very High
GABAergic 101 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 51 100.00 Very High Very High Very High
Generalized Anxiety Disorder 27 100.00 Very High Very High Very High
Nociception 16 99.98 Very High Very High Very High
Diabetes Mellitus 10 99.98 Very High Very High Very High
Urological Neuroanatomy 14 99.68 Very High Very High Very High
Injury 124 99.40 Very High Very High Very High
Cv Unclassified Under Development 86 99.32 Very High Very High Very High
Glioma 3 99.08 Very High Very High Very High
Death 21 98.96 Very High Very High Very High
Neuropathic Pain 68 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential regulation of GABA B receptor subunit expression and function.
Regulation (regulation) of Gene_expression (expression) of GABA associated with gaba
1) Confidence 0.51 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12649368 Disease Relevance 0.14 Pain Relevance 0.85
In this study, we evaluated whether the expression of GABA(B(1b)) receptor mRNA is regulated supraspinally, namely in the thalamus, as part of the response to chronically enhanced noxious input arising from experimental monoarthritis (MA).
Spec (whether) Regulation (regulated) of Gene_expression (expression) of GABA in thalamus associated with gaba and thalamus
2) Confidence 0.45 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.10 Pain Relevance 0.43
Perfusion of the neostriatum with morphine (100 microM) significantly increased GABA and dynorphin B levels in the ipsilateral substantia nigra, but no effect was observed locally.
Neg (no) Regulation (effect) of Gene_expression (levels) of GABA in substantia nigra associated with gaba, dynorphin, substantia nigra and morphine
3) Confidence 0.32 Published 1996 Journal Brain Res. Section Abstract Doc Link 8963665 Disease Relevance 0 Pain Relevance 1.98
These results suggest that there is no significant loss of GABAergic boutons from the denervated area after SNI (which is consistent with the finding that neuronal death does not occur in this model) and that there is no depletion of GABA or GABAA receptors at GABAergic synapses within this region.
Neg (no) Regulation (depletion) of Gene_expression (receptors) of GABA in boutons associated with gaba, nervous system injury, gabaergic and death
4) Confidence 0.29 Published 2008 Journal Neuroscience Section Abstract Doc Link PMC2553186 Disease Relevance 0.70 Pain Relevance 0.63
Using an animal model of neuropathic pain, behavioral and biochemical experiments were performed to assess the effects of this condition on pain threshold and GABA(B) receptor sensitivity and subunit gene expression in the rat lumbar spinal cord.
Regulation (effects) of Gene_expression (expression) of GABA in spinal cord associated with gaba, pain threshold, neuropathic pain and spinal cord
5) Confidence 0.25 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.62 Pain Relevance 1.11
These results suggest that the expression of GABA(B(1b)) in the VB and Po is regulated by noxious input, and might contribute to the functional changes that occur in the thalamus during chronic inflammatory pain.
Regulation (regulated) of Gene_expression (expression) of GABA in thalamus associated with gaba, ipn and thalamus
6) Confidence 0.24 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.10 Pain Relevance 0.43
The data suggest that GABA(B2) mRNA expression in the ventrobasal complex and posterior nucleus is regulated by noxious input and that GABA(B) receptors might play a role in the plasticity of these relay nuclei during chronic inflammatory pain.
Regulation (regulated) of Gene_expression (expression) of GABA in nucleus associated with gaba and ipn
7) Confidence 0.24 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113954 Disease Relevance 0.10 Pain Relevance 0.44
The effects of antidepressant administration on GABA(B(1b)) and GABA(B(2)) subunit expression in spinal cord are more variable than for GABA(B(1a)).
Regulation (effects) of Gene_expression (expression) of GABA in spinal cord associated with gaba, antidepressant and spinal cord
8) Confidence 0.23 Published 2006 Journal Brain Res. Section Abstract Doc Link 16368079 Disease Relevance 0.42 Pain Relevance 1.47
Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus.
Regulation (Effect) of Gene_expression (expression) of GABA in hippocampus associated with gaba, antidepressant and hippocampus
9) Confidence 0.23 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15451391 Disease Relevance 0.10 Pain Relevance 0.94
Role of GABA receptors in the action of sildenafil
Regulation (Role) of Gene_expression (receptors) of GABA associated with gaba receptor
10) Confidence 0.22 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799976 Disease Relevance 0.09 Pain Relevance 0.42
Nociceptive regulation of GABA(B) receptor gene expression in rat spinal cord.
Regulation (regulation) of Gene_expression (expression) of GABA in spinal cord associated with gaba, nociceptor and spinal cord
11) Confidence 0.21 Published 1999 Journal Neuropharmacology Section Title Doc Link 10587092 Disease Relevance 0.62 Pain Relevance 1.02
Inasmuch as acute and chronic pain alter the expression of a number of nociception-related receptors, and because such changes are important components in the regulation of pain, the present study was undertaken to determine whether GABA(B) receptor gene expression is altered in sensory systems following a peripheral nociceptive stimulus.
Spec (whether) Regulation (altered) of Gene_expression (expression) of GABA in sensory systems associated with nociception, pain, gaba and lasting pain
12) Confidence 0.21 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10587092 Disease Relevance 0.68 Pain Relevance 0.74
These findings indicate an activity-dependent, differential regulation of GABA(B) R1 and R2 receptor gene expression in spinal sensory systems in response to chemogenic nociceptive activation, suggesting that GABA(B) receptor plasticity may play an important role in regulating the mediation, and perception, of chronic pain.
Regulation (regulation) of Gene_expression (expression) of GABA in sensory systems associated with nociception, gaba and lasting pain
13) Confidence 0.21 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10587092 Disease Relevance 0.74 Pain Relevance 0.80
All of these antidepressants selectively increased the expression of the GABA(B(1a)) subunit in hippocampus, having no consistent effect on the expression of GABA(B(1b)) or GABA(B(2)).
Neg (no) Regulation (effect) of Gene_expression (expression) of GABA in hippocampus associated with gaba, antidepressant and hippocampus
14) Confidence 0.20 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451391 Disease Relevance 0.05 Pain Relevance 1.23
Although gabapentin may have several different pharmacological actions, it appears that modulation of GABA synthesis and glutamate synthesis may be important.
Regulation (modulation) of Gene_expression (synthesis) of GABA associated with glutamate, gaba and gabapentin
15) Confidence 0.20 Published 1997 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 9686247 Disease Relevance 0.62 Pain Relevance 1.39
Perez de la Mora et al (1999), seeking to find the manner in which modafinil could change glutamate and GABA levels of the hypothalamus, studied the effect of modafinil on glutamate and GABA synthesis in ex vivo and in vitro slices of the rat hypothalamus, by measuring tritium incorporation into glutamate and GABA and found no effect of modafinil on the synthesis of these neurotransmitters.
Regulation (effect) of Gene_expression (synthesis) of GABA in hypothalamus associated with neurotransmitter, gaba and glutamate
16) Confidence 0.20 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.09 Pain Relevance 0.90
Diabetes affects the expression of GABA and potassium chloride cotransporter in the spinal cord: a study in streptozotocin diabetic rats.
Regulation (affects) of Gene_expression (expression) of GABA in spinal cord associated with gaba, diabetes mellitus and spinal cord
17) Confidence 0.18 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18457921 Disease Relevance 0.65 Pain Relevance 0.54
The aim of the present microdialysis study was to investigate the effect of local administration of morphine on the extracellular GABA level in the PAG of awake rats.
Spec (investigate) Regulation (effect) of Gene_expression (level) of GABA in PAG associated with gaba, urological neuroanatomy and morphine
18) Confidence 0.16 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8736636 Disease Relevance 0.52 Pain Relevance 1.02
Perez de la Mora et al (1999), seeking to find the manner in which modafinil could change glutamate and GABA levels of the hypothalamus, studied the effect of modafinil on glutamate and GABA synthesis in ex vivo and in vitro slices of the rat hypothalamus, by measuring tritium incorporation into glutamate and GABA and found no effect of modafinil on the synthesis of these neurotransmitters.
Regulation (change) of Gene_expression (levels) of GABA in hypothalamus associated with neurotransmitter, gaba and glutamate
19) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.09 Pain Relevance 0.88
The results showed: (1) Pain stimulation increased norepinephrine (NE), but not epinephrine, dopamine (DA), 3,4-dihydroxyphenylacetic acid (DA metabolic product), homovanilic acid (DA metabolic product), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HT metabolic product), acetycholine (Ach), choline (Ach metabolic product), gamma-aminobutyric acid (GABA), and L-glutamate acid concentrations in the PVN perfusion liquid; (2) PVN stimulation with L-glutamate sodium, which excited local neurons only, did not influence the concentrations of the studied classical neurotransmitter and metabolic product in the PVN perfusion liquid; (3) Microinjection of NE, epinephrine, or L-glutamate sodium into the PVN elevated pain threshold, and local administration of GABA decreased pain threshold in a dose-dependent manner, but PVN administration of Ach, DA, or 5-HT did not change pain threshold; (4) Microinjection of phentolamine (alpha-receptor antagonist) or MK801 [NMDA-receptor antagonist] into the PVN reduced pain threshold, and local administration of bicuculline (GABA-receptor antagonist) raised pain threshold, but PVN administration of propranolol (beta-receptor antagonist), atropine (Muscarinic cholinergic receptor antagonist), 6-OH gallamine (Nicotinic cholinergic receptor antagonist), fluperidol (DA-receptor antagonist), or cyproheptadine (5-HT-receptor antagonist) did not alter pain threshold.
Neg (not) Regulation (influence) of Gene_expression (product) of GABA in PVN associated with pain, pain threshold, neurotransmitter, glutamate, gaba, dopamine, antagonist and serotonin
20) Confidence 0.14 Published 2010 Journal Int. J. Neurosci. Section Abstract Doc Link 20504214 Disease Relevance 0.60 Pain Relevance 1.77

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