INT63458

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
pyramidal cells 2
CSF 2
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 4 100.00 Very High Very High Very High
Pyramidal cell 1 94.80 High High
Eae 1 93.84 High High
Intracerebroventricular 1 83.48 Quite High
Hippocampus 1 79.28 Quite High
agonist 1 62.40 Quite High
Glutamate 1 60.56 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 76.68 Quite High
Movement Disorders 2 65.76 Quite High
Dystonia 2 64.36 Quite High
Dyskinesias 1 63.64 Quite High
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membranes from rats treated for 7 or 14 days with BD1047 showed a marked decrease in [3H](+)-pentazocine binding as compared to membranes from CSF-treated animals, suggesting a loss of sigma 1 receptor binding.
Negative_regulation (loss) of sigma 1 receptor Binding (binding) of in CSF associated with fortral
1) Confidence 0.36 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9137911 Disease Relevance 0.31 Pain Relevance 0.17
Trimethyltin was also shown to produce a marked reduction in the binding of [3H] (+)-pentazocine to sigma-receptor sites in limbic brain structures, as detected by quantitative autoradiography, which was particularly evident in the hippocampal pyramidal cells.
Negative_regulation (reduction) of sigma-receptor Binding (binding) of in pyramidal cells associated with fortral and pyramidal cell
2) Confidence 0.30 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8737963 Disease Relevance 0.08 Pain Relevance 0.35

General Comments

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