INT63481

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.39
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FOSL1) nucleus (FOSL1)
Anatomy Link Frequency
neurons 2
spinal cord 1
TMJ 1
neuronal 1
MBH 1
FOSL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 17 99.68 Very High Very High Very High
Nucleus accumbens 7 99.52 Very High Very High Very High
bradykinin 4 99.20 Very High Very High Very High
Snapping jaw 6 98.16 Very High Very High Very High
withdrawal 16 97.92 Very High Very High Very High
agonist 29 97.88 Very High Very High Very High
Spinal cord 15 95.00 High High
Dynorphin 11 94.60 High High
Opioid 5 94.20 High High
Enkephalin 4 93.36 High High
Disease Link Frequency Relevance Heat
Death 4 99.76 Very High Very High Very High
Temporomandibular Joint Syndrome 6 98.16 Very High Very High Very High
Cancer 22 97.08 Very High Very High Very High
INFLAMMATION 59 88.64 High High
Pain 13 54.40 Quite High
Metastasis 4 54.32 Quite High
Inflammatory Bowel Disease 1 51.80 Quite High
Arthritis 6 50.72 Quite High
Ganglion Cysts 24 50.00 Quite Low
Cold Sores 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Active integrin antagonist did not affect Fos-LI produced after injection of bradykinin alone into the TMJ.
Gene_expression (produced) of Fos-LI in TMJ associated with snapping jaw, antagonist and bradykinin
1) Confidence 0.75 Published 2006 Journal Pain Section Abstract Doc Link 16762506 Disease Relevance 0.56 Pain Relevance 0.93
A second experiment showed that somatic signs and FRA expression within the NAc could each be attenuated when the D2 agonist propylnorapomorphine (NPA; 0.1 or 0.3 mg/kg, i.p.) was administered prior to naltrexone-precipitated withdrawal.
Gene_expression (expression) of FRA in NAc associated with nucleus accumbens, agonist and withdrawal
2) Confidence 0.75 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10942854 Disease Relevance 0 Pain Relevance 1.22
Ten sections from each rat were randomly selected and the expression of Fos-LI and pERK1/2 evaluated by a blinded observer counting the number of immunopositive neurons in the gray matter of ipsilateral spinal cord.


Gene_expression (expression) of Fos-LI in spinal cord associated with spinal cord
3) Confidence 0.58 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0 Pain Relevance 0.08
At the same time, these drugs increased the expression of Fos/FRA-ir proteins, in particular the 35- and 40-kDa molecular weight species, and increased binding to the AP-1 DNA element.
Gene_expression (expression) of FRA
4) Confidence 0.58 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.59
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer.
Gene_expression (expression) of FOSL1 associated with cancer
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.45 Pain Relevance 0.21
We have observed that cultured glial cells express high basal levels of transcription factors, such as fos-related antigens (Fra), c-Jun, JunD, and cAMP responsive element binding protein (CREB).
Gene_expression (express) of Fra in glial cells
6) Confidence 0.04 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8738155 Disease Relevance 0 Pain Relevance 0.09
When neuronal cells are plated on top of the monolayers, the expression of Fra, c-Jun, JunD, and GFAP decreases in the astroglial cells.
Gene_expression (expression) of Fra in neuronal
7) Confidence 0.04 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8738155 Disease Relevance 0 Pain Relevance 0.08
Again, this increase in Fos/FRA expression in GnRH neurons was limited to the MBH.
Gene_expression (expression) of FRA in neurons
8) Confidence 0.01 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579360 Disease Relevance 0.09 Pain Relevance 0.21
This treatment increased Fos/FRA expression in MBH GnRH neurons approximately 10-fold compared with control rams.
Gene_expression (expression) of FRA in MBH
9) Confidence 0.01 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579360 Disease Relevance 0.09 Pain Relevance 0.20
These five ewes had a 6-fold increase in the percentage of GnRH neurons in the medial basal hypothalamus (MBH) expressing Fos/FRA, compared with control ewes that had no LH pulses before death.
Gene_expression (expressing) of FRA in medial associated with death
10) Confidence 0.01 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579360 Disease Relevance 0.10 Pain Relevance 0.20
Fos/FRA expression was not increased in GnRH neurons found in any other area.
Gene_expression (expression) of FRA in neurons
11) Confidence 0.01 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579360 Disease Relevance 0.10 Pain Relevance 0.20

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