INT63482

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FOSL1) nucleus (FOSL1)
Anatomy Link Frequency
NAc 2
neuronal 2
FOSL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 7 100.00 Very High Very High Very High
agonist 3 99.48 Very High Very High Very High
withdrawal 8 97.92 Very High Very High Very High
opiate 5 92.08 High High
Enkephalin 1 84.80 Quite High
dopamine receptor 1 75.00 Quite High
Dopamine 1 70.32 Quite High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second experiment showed that somatic signs and FRA expression within the NAc could each be attenuated when the D2 agonist propylnorapomorphine (NPA; 0.1 or 0.3 mg/kg, i.p.) was administered prior to naltrexone-precipitated withdrawal.
Negative_regulation (attenuated) of Gene_expression (expression) of FRA in NAc associated with nucleus accumbens, agonist and withdrawal
1) Confidence 0.57 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10942854 Disease Relevance 0 Pain Relevance 1.23
When neuronal cells are plated on top of the monolayers, the expression of Fra, c-Jun, JunD, and GFAP decreases in the astroglial cells.
Negative_regulation (decreases) of Gene_expression (expression) of Fra in neuronal
2) Confidence 0.03 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8738155 Disease Relevance 0 Pain Relevance 0.08

General Comments

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