INT63489

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Context Info
Confidence 0.01
First Reported 1996
Last Reported 1996
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.58
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1) nucleus (Rtcd1)
molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
striatum 1
Dio1 (Mus musculus)
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 99.82 Very High Very High Very High
Morphine 8 96.00 Very High Very High Very High
adenocard 4 93.48 High High
MU agonist 2 93.12 High High
Dopamine 4 90.12 High High
opioid receptor 6 85.80 High High
Opioid 2 83.28 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 10 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that in striatum of wild-type CD1 mice as in rat. mu-agonists inhibit D1-activated adenylyl cyclase, but were without inhibitory activity against A2a-activated adenylyl cyclase.
D1 Positive_regulation (activated) of cyclase in striatum associated with agonist
1) Confidence 0.01 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.24 Pain Relevance 0.68
In contrast, the delta 2 agonist, DT-II, inhibited both D1 and A2a activated enzyme in all strains except DBA/2J, where DT-II did not inhibit D1-activated adenylyl cyclase.
D1 Neg (except) Positive_regulation (activated) of cyclase associated with agonist and sprains and strains
2) Confidence 0.01 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738226 Disease Relevance 0.34 Pain Relevance 0.83

General Comments

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