INT63505

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 7.40
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
Anatomy Link Frequency
platelet 2
blood 1
sciatic nerve 1
lumen 1
cleavage 1
F2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 1 98.64 Very High Very High Very High
intrathecal 4 98.58 Very High Very High Very High
tetrodotoxin 5 98.52 Very High Very High Very High
agonist 4 98.24 Very High Very High Very High
Sciatic nerve 2 97.32 Very High Very High Very High
Brush evoked pain 3 96.82 Very High Very High Very High
Thermal hyperalgesia 3 96.38 Very High Very High Very High
Spinal cord 8 94.16 High High
Hyperalgesia 1 93.60 High High
antagonist 35 93.52 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 56 99.92 Very High Very High Very High
Esophageal Varices 6 99.60 Very High Very High Very High
Hemorrhage 18 99.50 Very High Very High Very High
Dysmenorrhea 1 98.64 Very High Very High Very High
Cancer 115 97.64 Very High Very High Very High
Hepatic Encephalopathy 92 97.30 Very High Very High Very High
Neuropathic Pain 7 96.82 Very High Very High Very High
Cirrhosis 138 96.80 Very High Very High Very High
Hyperalgesia 4 96.38 Very High Very High Very High
Sepsis 113 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound 1 reduced prothrombin time (PT), and strengthened mice uterine contractions.
Negative_regulation (reduced) of prothrombin in uterine associated with dismenorea
1) Confidence 0.57 Published 2010 Journal Nat Prod Commun Section Abstract Doc Link 20839632 Disease Relevance 0.28 Pain Relevance 0.10
Protease inhibitors which do not inhibit thrombin, including cystatin and aprotinin, had no effect on synapse reduction.
Negative_regulation (inhibit) of thrombin in synapse
2) Confidence 0.41 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9125468 Disease Relevance 0 Pain Relevance 0.17
Thermal hyperalgesia and tactile allodynia induced by sciatic nerve ligation were significantly suppressed by repeated intrathecal injection of hirudin, which is characterized as a specific and potent thrombin inhibitor.
Negative_regulation (inhibitor) of thrombin in sciatic nerve associated with brush evoked pain, thermal hyperalgesia, sciatic nerve and intrathecal
3) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16251448 Disease Relevance 0.75 Pain Relevance 1.05
Thus, as outlined schematically in Fig. 7, interference with steady state levels of factors of the coagulation cascade, such as occurs in Factor VIII KO mice or upon blockade of Factor Xa or thrombin, also overrules this checkpoint, thereby leading to oversized organs.
Negative_regulation (blockade) of thrombin
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.06 Pain Relevance 0
Interestingly, several of these activities, including platelet activation and stimulation of tumor cell proliferation[30], [31], are associated with promotion of growth, which is in opposition to our suggestion that inhibition of thrombin leads to massive overgrowth.
Negative_regulation (inhibition) of thrombin in platelet associated with cancer
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.30 Pain Relevance 0.08
Removal of HCO(3)(-) ions from the serosal buffer reduced responses to thrombin and trypsin by >80%.
Negative_regulation (reduced) of thrombin
6) Confidence 0.22 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17431214 Disease Relevance 0.46 Pain Relevance 0.30
Also, supplementation of vitamin K in conditions with high risk of bleeding such as the presence of impaired prothrombin time and oesophageal varices, should be considered [118].
Negative_regulation (impaired) of prothrombin associated with esophageal varices and hemorrhage
7) Confidence 0.21 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3017957 Disease Relevance 1.44 Pain Relevance 0.03
The mediation of this effect is by inhibition of the multifunctional serine protease, thrombin, because hirudin, a thrombin-specific inhibitor, has the same effect.
Negative_regulation (inhibition) of thrombin
8) Confidence 0.19 Published 1996 Journal J. Neurobiol. Section Abstract Doc Link 8738754 Disease Relevance 0.79 Pain Relevance 0.26
Some F2 animals were also crossed together to produce F3 mice.
Negative_regulation (crossed) of F2
9) Confidence 0.17 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 0.71 Pain Relevance 0
Since Clexane could potentially block not only Factor Xa, but also inhibits thrombin to some extent, further analysis was performed using a more specific inhibitor, namely, Dabigatran, which blocks only thrombin.
Negative_regulation (blocks) of thrombin
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0
Since Clexane could potentially block not only Factor Xa, but also inhibits thrombin to some extent, further analysis was performed using a more specific inhibitor, namely, Dabigatran, which blocks only thrombin.
Negative_regulation (inhibits) of thrombin
11) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0 Pain Relevance 0
The therapeutic benefit of acidifying the gut lumen with synbiotics in cirrhotic patients with minimal HE was demonstrated by Liu et al. [123] who showed that synbiotic/probiotic supplementation ameliorates hepatic function as reflected by reduced bilirubin and albumin levels and prothrombin times [123].
Negative_regulation (reduced) of prothrombin in lumen associated with cirrhosis and hepatic encephalopathy
12) Confidence 0.15 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3017957 Disease Relevance 0.76 Pain Relevance 0.04
Interestingly, vWbp·prothrombin activity (Fig. 5F) was impeded by both specific vWbp antibodies (P?
Negative_regulation (impeded) of prothrombin
13) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.21 Pain Relevance 0
-thrombin, the fibrinogen recognition site, and proexosite I on prothrombin are blocked by the D2 of Coa [20].
Negative_regulation (blocked) of thrombin
14) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2916881 Disease Relevance 0.28 Pain Relevance 0
Contrary to what was expected from the changes in pharmacokinetics, a statistically significant decrease in the effect of phenprocoumon on factor II and VII activity was observed for the sessions with lornoxicam co-administration.
Negative_regulation (decrease) of factor II
15) Confidence 0.05 Published 1999 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10027661 Disease Relevance 0 Pain Relevance 0
Despite these changes in pharmacokinetics, a decrease of the effect on factor II and VII activity was observed.
Negative_regulation (decrease) of factor II
16) Confidence 0.05 Published 1999 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10027661 Disease Relevance 0 Pain Relevance 0
A third anticoagulant, danaparoid sodium, also prevents blood clotting by inactivating
           thrombin. 
Negative_regulation (inactivating) of thrombin in blood associated with coagulation disorder
17) Confidence 0.03 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.71 Pain Relevance 0.11
Hirudin is perhaps the most potent inhibitor of thrombin, the enzyme responsible for fibrinogen cleavage, platelet activation, and SMC proliferation [54].
Negative_regulation (inhibitor) of thrombin in platelet
18) Confidence 0.02 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.33 Pain Relevance 0.03
Hirudin is perhaps the most potent inhibitor of thrombin, the enzyme responsible for fibrinogen cleavage, platelet activation, and SMC proliferation [54].
Negative_regulation (inhibitor) of thrombin in cleavage
19) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.33 Pain Relevance 0.03

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