INT63507

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 8.35
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SERPINE2) cytosol (SERPINE2) extracellular space (SERPINE2)
extracellular region (SERPINE2)
Anatomy Link Frequency
blood 1
neuronal 1
sciatic nerve 1
paw 1
SERPINE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 60 100.00 Very High Very High Very High
opioid receptor 16 100.00 Very High Very High Very High
Sciatic nerve 48 99.56 Very High Very High Very High
Pain 57 99.10 Very High Very High Very High
Neuropeptide 5 99.10 Very High Very High Very High
depression 142 98.92 Very High Very High Very High
Neuropathic pain 8 98.92 Very High Very High Very High
withdrawal 2 98.36 Very High Very High Very High
Inflammation 83 98.32 Very High Very High Very High
agonist 6 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 126 100.00 Very High Very High Very High
Epstein-barr Virus 6 99.04 Very High Very High Very High
Infection 8 98.98 Very High Very High Very High
Depression 134 98.92 Very High Very High Very High
Neuropathic Pain 18 98.92 Very High Very High Very High
INFLAMMATION 95 98.32 Very High Very High Very High
Injury 108 96.92 Very High Very High Very High
Pain 66 94.52 High High
Post-partum Depression 11 92.04 High High
Apoptosis 1 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, TrkB and serpin peptidase inhibitor, clade e (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) were present in the set of 1,663 genes and located in module 1.
Gene_expression (present) of SERPINE2
1) Confidence 0.70 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.60 Pain Relevance 0.58
The potent neuromodulator, vasoactive intestinal polypeptide (VIP), influences neuronal survival through glial-mediated factors and also induces secretion of newly synthesized astrocyte PNI.
Gene_expression (synthesized) of PNI in neuronal
2) Confidence 0.63 Published 1996 Journal J. Neurobiol. Section Abstract Doc Link 8738754 Disease Relevance 0.87 Pain Relevance 0.24
Oligonucleotide microarrays were used to examine PNI gene expression in the peripheral blood of 13 subjects with infectious mononucleosis (IM).
Spec (examine) Gene_expression (expression) of PNI in blood associated with epstein-barr virus
3) Confidence 0.14 Published 2006 Journal Brain Res. Section Abstract Doc Link 16376318 Disease Relevance 0.54 Pain Relevance 0.07
In addition, several key PNI and psychiatry journals were manually searched for relevant articles including Psychoneuroendocrinology, Psychosomatic Medicine, Psychosomatic Research, Biological Psychiatry, Health Psychology, American Journal of Psychiatry, British Journal of Psychiatry, and British Medical Journal.
Gene_expression (searched) of PNI
4) Confidence 0.12 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 1.60 Pain Relevance 0.71
Acute infection is known to perturb psycho-neuroendocrine-immune (PNI) gene expression.
Gene_expression (expression) of PNI associated with infection
5) Confidence 0.11 Published 2006 Journal Brain Res. Section Abstract Doc Link 16376318 Disease Relevance 0.52 Pain Relevance 0.06
Our findings open up the possibility that PNI and activating TRPV1-expressing primary afferents may cause increased BSCB and BBB permeability in humans.
Gene_expression (expressing) of PNI associated with peripheral nerve injury
6) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0.89 Pain Relevance 0.42
Correlation of psycho-neuroendocrine-immune (PNI) gene expression with symptoms of acute infectious mononucleosis.
Gene_expression (expression) of PNI associated with neuropeptide and epstein-barr virus
7) Confidence 0.10 Published 2006 Journal Brain Res. Section Title Doc Link 16376318 Disease Relevance 0.59 Pain Relevance 0.32
Here we show that peripheral nerve injury (PNI) produced by either sciatic nerve constriction or transecting two of its main branches causes an increase in BSCB permeability, as assessed by using Evans Blue dye or horseradish peroxidase.
Gene_expression (produced) of PNI in sciatic nerve associated with nervous system injury, sciatic nerve and peripheral nerve injury
8) Confidence 0.10 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2984489 Disease Relevance 0.80 Pain Relevance 0.68
However, an up-regulation of DOR protein was found in neuropathic DRG compared to sham, suggesting that there may be a bilateral increase in the expression of DOR following PNI.
Gene_expression (expression) of PNI associated with neuropathic pain, opioid receptor and peripheral nerve injury
9) Confidence 0.03 Published 2007 Journal Pain Section Abstract Doc Link 16963185 Disease Relevance 1.13 Pain Relevance 1.29
Peripheral nerve injury (PNI) produced a time-dependent decrease in mechanical withdrawal thresholds that was attenuated by local administration into the hind paw of either morphine or the DOR agonist deltorphin II.
Gene_expression (produced) of PNI in paw associated with nervous system injury, agonist, opioid receptor, withdrawal, morphine and peripheral nerve injury
10) Confidence 0.03 Published 2007 Journal Pain Section Abstract Doc Link 16963185 Disease Relevance 0.81 Pain Relevance 1.18

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