INT63524

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Context Info
Confidence 0.61
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.42
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
joint 4
NK cells 2
body 1
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 39 99.56 Very High Very High Very High
Enkephalin 10 99.34 Very High Very High Very High
positron emission tomography 5 99.20 Very High Very High Very High
Opioid 2 98.66 Very High Very High Very High
Arthritis 596 85.84 High High
deep brain stimulation 40 73.24 Quite High
Inflammation 48 48.08 Quite Low
Etanercept 5 43.96 Quite Low
narcan 3 41.28 Quite Low
opioid receptor 1 39.36 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 87 97.70 Very High Very High Very High
Autoimmune Disease 46 92.64 High High
Arthritis 692 85.84 High High
Sprains And Strains 55 85.16 High High
Renal Disease 5 84.20 Quite High
Systemic Lupus Erythematosus 5 80.88 Quite High
Immunization 66 78.08 Quite High
Immune Complex Diseases 5 77.92 Quite High
Syndrome 19 60.80 Quite High
Disease 63 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quite surprisingly, the target antigen recognized by both the transgenic T cells and the pathogenic autoantibodies was not joint-specific but the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI, or GPI) [66].
Localization (isomerase) of G6PI in joint associated with targeted disruption
1) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.99 Pain Relevance 0.30
Quite surprisingly, the target antigen recognized by both the transgenic T cells and the pathogenic autoantibodies was not joint-specific but the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI, or GPI) [66].
Localization (isomerase) of glucose-6-phosphate in joint associated with targeted disruption
2) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.00 Pain Relevance 0.30
In addition to its function as a glycolytic enzyme, G6PI can be secreted and serves a variety of other physiological functions [99].
Localization (secreted) of G6PI
3) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.76 Pain Relevance 0.12
This contention is further supported by positron emission tomography studies [95,96] that demonstrate rapid localization of adoptively transferred antibodies against G6PI to the peripheral joints of the recipient mice.
Localization (localization) of G6PI in joints associated with positron emission tomography
4) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.87 Pain Relevance 0.29
Quite surprisingly, the target antigen recognized by both the transgenic T cells and the pathogenic autoantibodies was not joint-specific but the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI, or GPI) [66].
Localization (isomerase) of GPI in joint associated with targeted disruption
5) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.00 Pain Relevance 0.30
This work has explored the possibility that alterations of NK activity induced by the opioid pentapeptide leu-enkephalin (LENK) may reflect the alterations in secretion of IFN, an important regulator of NK activity.
Localization (secretion) of NK associated with enkephalin and opioid
6) Confidence 0.47 Published 1996 Journal Res Exp Med (Berl) Section Abstract Doc Link 8739803 Disease Relevance 0 Pain Relevance 0.66
Finally, it is suggested that, if MER is being used, probably less than five channels are necessary and MER could also be started closer than 8 and 12 mm for the MRI-based STN target and GPi target, respectively.



Localization (target) of GPi associated with imagery
7) Confidence 0.40 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0 Pain Relevance 0.17
G6PI is systemically distributed in the body because it is expressed intracellular in all cells as an enzyme of glycolysis and can furthermore be secreted.
Localization (secreted) of G6PI in body
8) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 0.80 Pain Relevance 0.33
The percentage of NK cytotoxicity, was calculated by the following formula: NK cytotoxicity (%) = [(experimental value - spontaneous release)/(maximum release - spontaneous release)] × 100 %

Staining of NK cells

Localization (release) of NK in NK cells
9) Confidence 0.08 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 0 Pain Relevance 0
The percentage of NK cytotoxicity, was calculated by the following formula: NK cytotoxicity (%) = [(experimental value - spontaneous release)/(maximum release - spontaneous release)] × 100 %

Staining of NK cells

Localization (release) of NK in NK cells
10) Confidence 0.08 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 0 Pain Relevance 0

General Comments

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