INT63534

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 6.84
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
isthmus 2
fundus 2
central nervous system 2
neurons 1
visceral muscles 1
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 99.76 Very High Very High Very High
Central nervous system 4 99.32 Very High Very High Very High
Pain 5 97.80 Very High Very High Very High
antagonist 189 95.88 Very High Very High Very High
Opioid 2 95.20 Very High Very High Very High
Locus ceruleus 1 94.44 High High
Enkephalin 1 94.44 High High
Serotonin 4 94.32 High High
Inflammatory mediators 3 94.32 High High
substance P 1 91.36 High High
Disease Link Frequency Relevance Heat
Heart Failure 62 100.00 Very High Very High Very High
Chronic Renal Failure 55 100.00 Very High Very High Very High
Fatigue 28 100.00 Very High Very High Very High
Pulmonary Disease 66 99.98 Very High Very High Very High
Dyskinesias 1 98.68 Very High Very High Very High
Stress 66 97.88 Very High Very High Very High
Birth Weight 2 97.84 Very High Very High Very High
Pain 6 97.80 Very High Very High Very High
Pre-term Labor 52 97.00 Very High Very High Very High
Sepsis 33 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of gastric emptying by CRF may be mediated by the interaction with the CRF2 receptors, while the anxiogenic and colonic motor responses may involve CRF1 receptors.
CRF Binding (interaction) of
1) Confidence 0.47 Published 1999 Journal Can. J. Gastroenterol. Section Abstract Doc Link 10202204 Disease Relevance 0.27 Pain Relevance 0.13
Corticotropin releasing hormone is released from the hypothalamus, binding to visceral muscles and causing abnormal movement of the colon [9,17].
Corticotropin releasing hormone Binding (binding) of in visceral muscles associated with dyskinesias
2) Confidence 0.37 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.75 Pain Relevance 0.41
Corticotropin-releasing hormone (CRH) is produced and acts both within the central nervous system and at several peripheral sites.
CRH Binding (acts) of in central nervous system associated with central nervous system
3) Confidence 0.36 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8739889 Disease Relevance 0 Pain Relevance 0.05
Corticotropin-releasing hormone (CRH) is produced and acts both within the central nervous system and at several peripheral sites.
Corticotropin-releasing hormone Binding (acts) of in central nervous system associated with central nervous system
4) Confidence 0.36 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8739889 Disease Relevance 0 Pain Relevance 0.05
Information regarding energy balance is fed back to the paraventricular nucleus of the hypothalamus where a complex interplay between thyrotropin-releasing hormone (TRH) and corticotrophin-releasing hormone (CRH) determines consequent effects in thermogenesis and stress reactions.
CRH Binding (interplay) of in nucleus associated with stress
5) Confidence 0.36 Published 1998 Journal Thyroid Section Abstract Doc Link 9827664 Disease Relevance 0.36 Pain Relevance 0.17
CRH and/or cortisol have also been associated with impaired fetal habituation to stimuli and temperamental difficulties in infants.
CRH Binding (associated) of
6) Confidence 0.36 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15944068 Disease Relevance 0.56 Pain Relevance 0.14
No differences were observed with respect to staining for CRH, CRH-BP, CRH-R1 and CRH-R2 in biopsies from the isthmus and fundus of the same non-pregnant patient, but there were pronounced differences between various individuals within the group.
CRH Binding (staining) of in fundus
7) Confidence 0.36 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0 Pain Relevance 0
No differences were observed with respect to staining for CRH, CRH-BP, CRH-R1 and CRH-R2 in biopsies from the isthmus and fundus of the same non-pregnant patient, but there were pronounced differences between various individuals within the group.
CRH Binding (staining) of in fundus
8) Confidence 0.36 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0 Pain Relevance 0
The acylphloroglucinole hyperforin failed to inhibit 125I-astressin binding to hCRF, receptor up to 10 microM.
CRF Binding (binding) of
9) Confidence 0.35 Published 2001 Journal Pharmacopsychiatry Section Abstract Doc Link 11518063 Disease Relevance 0 Pain Relevance 0.44
The current study finding indicates that management of CRF and QOL may be more effective if improvements in psychological and emotional functioning are targeted as well as physical functioning, as in the case of the MQ intervention.
CRF Binding (management) of associated with fatigue
10) Confidence 0.35 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2826100 Disease Relevance 1.53 Pain Relevance 0.09
Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons.
corticotropin releasing factor Neg (no) Binding (interaction) of in neurons associated with qutenza
11) Confidence 0.35 Published 2003 Journal Neuropeptides Section Title Doc Link 12906840 Disease Relevance 0 Pain Relevance 0.76
Corticotropin-releasing hormone, its binding protein and receptors in human cervical tissue at preterm and term labor in comparison to non-pregnant state

Background

Corticotropin-releasing hormone Binding (binding) of
12) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Title Doc Link PMC1513580 Disease Relevance 0.24 Pain Relevance 0
may interfere with CRH and ACTH synthesis [20].


CRH Binding (interfere) of
13) Confidence 0.24 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.92 Pain Relevance 0.43
CRHBP plays an important role in binding of corticotrophin releasing hormone (CRH) of the HPA axis.
CRH Binding (binding) of
14) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.14 Pain Relevance 0
3.2 Whether and to what extent do the preferences with regard to life-sustaining treatments of patients with severe to very severe COPD differ from those of patients with end-stage CHF or CRF?
CRF Binding (differ) of associated with chronic renal failure, pulmonary disease and heart failure
15) Confidence 0.19 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.97 Pain Relevance 0
No differences were observed with respect to staining for CRH, CRH-BP, CRH-R1 and CRH-R2 in biopsies from the isthmus and fundus of the same non-pregnant patient, but there were pronounced differences between various individuals within the group.
CRH Binding (staining) of in isthmus
16) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0 Pain Relevance 0
No differences were observed with respect to staining for CRH, CRH-BP, CRH-R1 and CRH-R2 in biopsies from the isthmus and fundus of the same non-pregnant patient, but there were pronounced differences between various individuals within the group.
CRH Binding (staining) of in isthmus
17) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0 Pain Relevance 0
In this model, CRF binding is described by the two-domain mechanism.
CRF Binding (binding) of
18) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0 Pain Relevance 0.18
The use of [125I]CRF enabled detection of the initial lead compounds because this radioligand binds strongly to the J-domain of the CRF1 receptor [38].
CRF Binding (binds) of
19) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0.06 Pain Relevance 0.06
Nonpeptide binding does not affect CRF binding to the N-domain, but allosterically inhibits CRF binding to the J-domain.
CRF Binding (binding) of
20) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox