INT63535

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Context Info
Confidence 0.35
First Reported 1996
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (HERPUD1) molecular_function (HERPUD1) response to stress (HERPUD1)
Anatomy Link Frequency
brain 1
reticulum 1
HERPUD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 1 100.00 Very High Very High Very High
Intracerebroventricular 1 82.64 Quite High
Central nervous system 1 51.08 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Sciatic nerve 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 98.08 Very High Very High Very High
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four genes were significantly regulated in all three tissues: Per2, Nr1d2 (nuclear receptor subfamily 1, group D, member 2), Herpud1 (homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1), and Oazi (ornithine decarboxylase antizyme inhibitor) (Figures 1, 2).
Regulation (regulated) of Herpud1 in reticulum associated with stress
1) Confidence 0.35 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.16 Pain Relevance 0
An indirect influence of the endogenous opiate modulating peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2, 5 nmol) was apparent by a change in the initial distribution within the brain.
Regulation (influence) of Tyr-MIF-1 in brain associated with opiate
2) Confidence 0.00 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8739889 Disease Relevance 0 Pain Relevance 0.17

General Comments

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