INT6354

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Context Info
Confidence 0.74
First Reported 1981
Last Reported 2011
Negated 1
Speculated 8
Reported most in Abstract
Documents 321
Total Number 342
Disease Relevance 41.41
Pain Relevance 186.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 33
interneurons 13
brain 11
hippocampus 7
dentate gyrus 6
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 4861 100.00 Very High Very High Very High
Neurotransmitter 930 100.00 Very High Very High Very High
antagonist 856 100.00 Very High Very High Very High
Glutamate 824 100.00 Very High Very High Very High
Dopamine 521 100.00 Very High Very High Very High
GABA receptor 242 100.00 Very High Very High Very High
Enkephalin 51 100.00 Very High Very High Very High
Catecholamine 22 100.00 Very High Very High Very High
long-term potentiation 395 99.92 Very High Very High Very High
noradrenaline 93 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 17 99.90 Very High Very High Very High
Rheumatoid Arthritis 25 99.88 Very High Very High Very High
Convulsion 226 99.74 Very High Very High Very High
Sensorineural Hearing Loss 198 99.62 Very High Very High Very High
Epilepsy 245 99.48 Very High Very High Very High
Sprains And Strains 187 99.46 Very High Very High Very High
Stress 186 99.40 Very High Very High Very High
Increased Venous Pressure Under Development 48 99.40 Very High Very High Very High
Urological Neuroanatomy 76 99.20 Very High Very High Very High
Generalized Anxiety Disorder 253 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If present, such molecular diversity could permit the selective targeting of GABA(B) receptor subtypes specifically involved in pathologies such as drug addiction, spasticity, pain, and epilepsy.
Localization (targeting) of GABA associated with epilepsy, drug dependence, pain, addiction, gaba and spasticity
1) Confidence 0.74 Published 2001 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 11414794 Disease Relevance 0.58 Pain Relevance 0.64
The GABAA receptor itself is a heteropentameric complex composed of five different subunits, and 19 subunits (?
Localization (receptor) of GABAA
2) Confidence 0.73 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0 Pain Relevance 0.25
METHODS: The effects of propofol and 4-iodopropofol were analyzed on heterologously expressed recombinant human GABAA alpha1beta2gamma2 receptors, evoked population spike amplitudes in rat hippocampal slices, and glutamate release from rat cerebrocortical synaptosomes in vitro.
Localization (release) of GABAA in spike
3) Confidence 0.73 Published 2001 Journal Anesthesiology Section Body Doc Link 11465597 Disease Relevance 0 Pain Relevance 0
Veratridine- (sodium channel-) dependent release of the neurotransmitters L-glutamate and GABA was almost fully inhibited by 20(S)-protopanaxadiol, however, less complete inhibition was observed with Rh(2).
Localization (release) of GABA associated with gaba, glutamate, neurotransmitter and sodium channel
4) Confidence 0.70 Published 2008 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 18262850 Disease Relevance 0 Pain Relevance 0.75
At its maximum inhibitory concentration, Rh(2) also produced release of l-glutamate and GABA from synaptosomes, in contrast to 20(S)-protopanaxadiol.
Localization (release) of GABA associated with gaba and glutamate
5) Confidence 0.70 Published 2008 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 18262850 Disease Relevance 0 Pain Relevance 0.75
Pharmacological characterization of nicotinic receptor-stimulated GABA release from mouse brain synaptosomes.
Localization (release) of GABA in brain associated with gaba
6) Confidence 0.70 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9808692 Disease Relevance 0 Pain Relevance 0.83
Studies on the ionic dependence showed that the stimulation of GABA release by EGTA was abolished in a Na+-free medium.
Localization (release) of GABA associated with addiction and gaba
7) Confidence 0.69 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6144725 Disease Relevance 0 Pain Relevance 0.59
The release of gamma-aminobutyric acid (GABA) was studied by comparing the properties of labeled GABA released from preloaded preparations to those of endogenous GABA released from the isolated guinea pig ileum.
Localization (released) of GABA in ileum associated with gaba
8) Confidence 0.69 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6638195 Disease Relevance 0 Pain Relevance 0.44
Thus the nature of the stimulation-evoked release of labeled GABA was similar to that of endogenous GABA.
Localization (release) of GABA associated with gaba
9) Confidence 0.69 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6638195 Disease Relevance 0 Pain Relevance 0.65
In the hippocampus, the tonic conductance is also activated by GABA released by action potential dependent vesicular mechanism [26].
Localization (released) of GABA in hippocampus associated with action potential, gaba and hippocampus
10) Confidence 0.68 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0 Pain Relevance 0.54
Immunolocalization of GABAA receptor subunits was hampered, due to availability of suitable antisera, but localization of GABAA-?
Localization (localization) of GABAA
11) Confidence 0.64 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0 Pain Relevance 0.30
A Na+ channel blocker, tetrodotoxin did not reduce GABA-evoked CA release.
Localization (release) of GABA associated with tetrodotoxin, gaba and catecholamine
12) Confidence 0.63 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6472489 Disease Relevance 0 Pain Relevance 1.10
The inhibitory neurotransmitter GABA is synthesized and released by horizontal cells and several subtypes of amacrine cells including dopaminergic amacrine cells.
Localization (released) of GABA in amacrine cells associated with gaba and neurotransmitter
13) Confidence 0.63 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.74
In addition, TTX blockade of sodium-dependent action potentials itself would have significantly reduced the spike-mediated release of GABA, glycine, glutamate, acetylcholine, and dopamine by amacrine and ganglion cells of the inner retina, reinforcing the negative findings with the pharmacological blockers specific to each of these transmitter systems.
Localization (release) of GABA in retina associated with ganglion cysts, action potential, tetrodotoxin, dopamine, glutamate and gaba
14) Confidence 0.63 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.10 Pain Relevance 0.56
Among these studies are those that have demonstrated the colocalization of enkephalin and GABA in retinal amacrine cells.
Localization (colocalization) of GABA in amacrine cells associated with gaba and enkephalin
15) Confidence 0.62 Published 1994 Journal Brain Res. Section Abstract Doc Link 8131082 Disease Relevance 0 Pain Relevance 0.96
The Ca(2+)-dependent fraction of the [3H]GABA released by high K+ depolarization is also completely abolished by amiloride (from 300 microM) and sensitive to verapamil (30 microM), but in contrast is insensitive to the absence of external Na+ and to DABA.
Localization (released) of GABA in external associated with gaba
16) Confidence 0.62 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8255356 Disease Relevance 0 Pain Relevance 0.52
The Ca(2+)-dependent, presumably exocytotic fraction of the [3H]GABA released by depolarization is dissected from the depolarization-induced Na(+)-dependent, carrier-mediated fraction of [3H]GABA release in mouse brain synaptosomes.
Localization (release) of GABA in brain associated with gaba
17) Confidence 0.62 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8255356 Disease Relevance 0 Pain Relevance 0.44
Vesicular and carrier-mediated depolarization-induced release of [3H]GABA: inhibition by amiloride and verapamil.
Localization (release) of GABA associated with gaba
18) Confidence 0.62 Published 1993 Journal Neurochem. Res. Section Title Doc Link 8255356 Disease Relevance 0 Pain Relevance 0.49
The absence of external Na+ completely abolishes the release of the carrier-mediated, presumably cytoplasmic release of [3H]GABA induced by homoexchange and heteroexchange with GABA and DABA, respectively.
Localization (release) of GABA in external associated with gaba
19) Confidence 0.62 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8255356 Disease Relevance 0 Pain Relevance 0.51
The carrier-mediated, Na(+)-dependent fraction of the depolarization-induced release of [3H]GABA is resistant to tetrodotoxin (TTX) but is sensitive to amiloride and verapamil.
Localization (release) of GABA associated with tetrodotoxin and gaba
20) Confidence 0.62 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8255356 Disease Relevance 0 Pain Relevance 0.53

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