INT63543

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Context Info
Confidence 0.13
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.00

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signal transduction (Adra2a) extracellular region (Serpini1) plasma membrane (Adra2a)
cytoplasm (Adra2a) signal transducer activity (Adra2a)
Adra2a (Rattus norvegicus)
Serpini1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
Clonidine 4 96.82 Very High Very High Very High
agonist 10 96.62 Very High Very High Very High
noradrenaline 2 95.76 Very High Very High Very High
Locus ceruleus 9 84.76 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concentration-response curves were obtained for the alpha 2-agonist noradrenaline and the mixed I1/alpha 2-receptor agonists clonidine, rilmenidine and moxonidine in slices without treatment and in slices treated with 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SK&F86466) or EEDQ, alpha 2-adrenoceptor antagonists with low affinity for I1 and I2 imidazoline receptors, respectively.
alpha 2-adrenoceptor Binding (affinity) of I1 associated with antagonist, noradrenaline, agonist and clonidine
1) Confidence 0.13 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8740150 Disease Relevance 0 Pain Relevance 1.00

General Comments

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