INT63550

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Context Info
Confidence 0.25
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.22
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
osteoclasts 4
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 94.40 High High
metalloproteinase 92 70.04 Quite High
Osteoarthritis 78 66.48 Quite High
cytokine 8 52.44 Quite High
Inflammation 6 51.48 Quite High
cINOD 8 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 118 99.88 Very High Very High Very High
Cancer 38 99.86 Very High Very High Very High
Acne 12 99.84 Very High Very High Very High
Hypercalcemia 36 96.96 Very High Very High Very High
Fever 1 95.44 Very High Very High Very High
Pain 3 94.40 High High
Osteomyelitis 1 91.56 High High
Disease 17 79.24 Quite High
Osteoarthritis 80 66.48 Quite High
INFLAMMATION 10 51.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence to determine whether breast cancer cell mediated degradation of type I collagen could be extended to a more physiological system, cancer cells were cultured on bone matrix as described below.


Positive_regulation (mediated) of Protein_catabolism (degradation) of type I collagen associated with cancer and breast cancer
1) Confidence 0.25 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.67 Pain Relevance 0
Increased degradation of type I collagen in acne fulminans.
Positive_regulation (Increased) of Protein_catabolism (degradation) of type I collagen associated with acne
2) Confidence 0.21 Published 1996 Journal Acta Derm. Venereol. Section Title Doc Link 8740265 Disease Relevance 1.27 Pain Relevance 0.09
(10-10M) and cultured in the presence of 10% FCS the cancer cells induced significant degradation of type I collagen (range 70–80%), whereas minimal degradation was observed in the absence of serum (Fig. 1).
Positive_regulation (induced) of Protein_catabolism (degradation) of type I collagen associated with cancer
3) Confidence 0.18 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.74 Pain Relevance 0.06
The role of MMP-13 in bone biology is of major importance as, on the one hand, MMP-13 secretion from the osteoblasts could be responsible for increasing type I collagen degradation and, on the other hand, in osteoclasts it could contribute to an increased bone resorption process.
Positive_regulation (responsible) of Protein_catabolism (degradation) of type I collagen in osteoclasts associated with hypercalcemia
4) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.27 Pain Relevance 0.12
The role of MMP-13 in bone biology is of major importance as, on the one hand, MMP-13 secretion from the osteoblasts could be responsible for increasing type I collagen degradation and, on the other hand, in osteoclasts it could contribute to an increased bone resorption process.
Positive_regulation (increasing) of Protein_catabolism (degradation) of type I collagen in osteoclasts associated with hypercalcemia
5) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.27 Pain Relevance 0.11

General Comments

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