INT63553

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 12.51
Pain Relevance 14.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
brain 2
plasma 1
lateral column 1
spinal cord 1
locus coeruleus 1
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 368 100.00 Very High Very High Very High
amygdala 272 100.00 Very High Very High Very High
Osteoarthritis 228 100.00 Very High Very High Very High
Chronic low back pain 189 100.00 Very High Very High Very High
insula 65 100.00 Very High Very High Very High
Periaqueductal grey 47 100.00 Very High Very High Very High
Hippocampus 13 100.00 Very High Very High Very High
opiate 9 100.00 Very High Very High Very High
Opioid 26 99.96 Very High Very High Very High
Acupuncture 437 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 480 100.00 Very High Very High Very High
Knee Osteoarthritis 225 100.00 Very High Very High Very High
Low Back Pain 192 100.00 Very High Very High Very High
Pain 695 99.28 Very High Very High Very High
Stress 306 96.52 Very High Very High Very High
Headache 78 96.08 Very High Very High Very High
Cognitive Disorder 8 92.40 High High
Cluster Headache 6 89.60 High High
INFLAMMATION 20 88.44 High High
Nociception 41 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus these studies potentially provide mechanistic explanations for the different brain activity associated with OA and CBP and their possible contribution to the resultant perceptions.
CBP Binding (associated) of in brain associated with chronic low back pain and osteoarthritis
1) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584040 Disease Relevance 1.52 Pain Relevance 1.62
Therefore, the obtained results cannot be generalized to the population at large, neither for CBP nor for OA.
CBP Neg (neither) Binding (generalized) of associated with chronic low back pain and osteoarthritis
2) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584040 Disease Relevance 1.47 Pain Relevance 1.34
Brain activity in CBP and OA
CBP Binding (activity) of in Brain associated with chronic low back pain and osteoarthritis
3) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584040 Disease Relevance 1.65 Pain Relevance 1.72
binding sites in the ventrolateral PAG attenuates the development of tolerance
PAG Binding (binding) of associated with tolerance and central grey
4) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.00 Pain Relevance 2.18
The central processing of the pain-relevant/anticipatory arousal also engaged the PAG.
PAG Binding (engaged) of associated with pain and central grey
5) Confidence 0.31 Published 1996 Journal Pain Section Abstract Doc Link 8740608 Disease Relevance 1.43 Pain Relevance 1.04
METHODS AND RESULTS: 16 patients undergoing DBS of the rostral PAG for chronic neuropathic pain were investigated post-operatively to determine whether PAG stimulation would alter HRV, and the subjects' perception of pain.
PAG Spec (determine) Binding (undergoing) of in PAG
6) Confidence 0.28 Published 2010 Journal Exp. Neurol. Section Body Doc Link 20178783 Disease Relevance 0 Pain Relevance 0
The PAG has abundant opiate receptors and participates in both opioid analgesia and acupuncture analgesia [5,8].
PAG Binding (participates) of associated with urological neuroanatomy, acupuncture, opiate, opioid and analgesia
7) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2596101 Disease Relevance 0.65 Pain Relevance 1.58
Besides showing the overlapped regions with the above network, the post-acupuncture condition engaged other brain regions including the medial prefrontal cortex (MPC), postcentral gyrus (PCG), insula, and PAG.
PAG Binding (engaged) of in insula associated with insula, urological neuroanatomy and acupuncture
8) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2596101 Disease Relevance 0.16 Pain Relevance 0.78
The NSAID dipyrone (metamizol) has been shown to engage opioidergic circuits at the PAG, the NRM and the spinal cord, but it is unknown whether this can be generalized to typical NSAIDs and to systemic administration.
PAG Binding (engage) of in spinal cord associated with raphe magnus, cinod, urological neuroanatomy and spinal cord
9) Confidence 0.19 Published 2004 Journal Pain Section Abstract Doc Link 15327823 Disease Relevance 0.67 Pain Relevance 1.24
Such time-dependent neural responses derived from the change-point analysis indicated different engagements of neural mechanisms, such as a decreased tendency in the amygdala and hippocampus, intermittent increased activities in the hypothalamus and PAG, sustained responses in the insula and PFC.
PAG Binding (engagements) of in neural associated with insula, hippocampus, central grey and amygdala
10) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989943 Disease Relevance 0.19 Pain Relevance 0.73
have shown recently that ALLO from the plasma gains ready access to the PAG
PAG Binding (access) of in plasma associated with periaqueductal grey
11) Confidence 0.17 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 0.16 Pain Relevance 0.24
pCREB lir selectively in the right lateral column of the PAG, and that CeA-PAG potentiation persists longer in the right hemisphere, it has been suggested
PAG Binding (potentiation) of in lateral column associated with amygdala and central grey
12) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.40 Pain Relevance 0.62
analyses varied with column of the PAG,
PAG Binding (column) of associated with central grey
13) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.83 Pain Relevance 0.24
aimed at the PAG (verified
PAG Binding (aimed) of associated with central grey
14) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.40 Pain Relevance 0.26
Lance [66], Diener and May [67], and Welch [68] have proposed to consider the participation in the migraine pathogenesis of orbital, frontal and limbic cortical areas and brainstem structures specialized in controlling pain mechanisms , like trigeminal nucleus caudalis, locus coeruleus, raphe nuccleus dorsalis,, PAG and area postrema, interacting with several neurotransmitters as noradrenaline, serotonin, dopamine and others, which could be “migraine generators”.
PAG Binding (interacting) of in locus coeruleus associated with pain, dopamine, locus ceruleus, migraine, medulla, neurotransmitter, noradrenaline, urological neuroanatomy, raphe and serotonin
15) Confidence 0.02 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2771268 Disease Relevance 0.98 Pain Relevance 1.16

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