INT6357

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Context Info
Confidence 0.41
First Reported 1982
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 53
Total Number 66
Disease Relevance 7.03
Pain Relevance 39.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 20
interneurons 6
projection neurons 6
CeA 4
Purkinje cells 4
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 902 100.00 Very High Very High Very High
Neurotransmitter 129 100.00 Very High Very High Very High
Action potential 98 100.00 Very High Very High Very High
Glutamate 97 100.00 Very High Very High Very High
tetrodotoxin 73 100.00 Very High Very High Very High
agonist 112 99.98 Very High Very High Very High
Nicotine 14 99.98 Very High Very High Very High
noradrenaline 12 99.98 Very High Very High Very High
amygdala 1388 99.84 Very High Very High Very High
narcan 31 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 23 99.06 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.06 Very High Very High Very High
Drug Dependence 4 98.92 Very High Very High Very High
Targeted Disruption 64 98.84 Very High Very High Very High
Epilepsy 17 97.64 Very High Very High Very High
Ganglion Cysts 34 97.36 Very High Very High Very High
Depression 109 96.80 Very High Very High Very High
Rheumatoid Arthritis 5 96.40 Very High Very High Very High
Generalized Anxiety Disorder 47 95.48 Very High Very High Very High
Tremor 5 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of these results we conclude that amiloride and verapamil inhibit high K(+)-induced release of [3H]GABA by antagonizing the entrance of Ca2+ (and possibly Na+ when external Ca2+ is absent) through a population of voltage sensitive presynaptic Ca2+ channels activated by depolarization.
Positive_regulation (induced) of Localization (release) of GABA in external associated with gaba
1) Confidence 0.41 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8255356 Disease Relevance 0 Pain Relevance 0.47
Nicotine increased [3H]-GABA release from synaptosomes preloaded with [3H]-GABA in a concentration-dependent manner.
Positive_regulation (increased) of Localization (release) of GABA associated with gaba and nicotine
2) Confidence 0.40 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808692 Disease Relevance 0 Pain Relevance 0.68
Several recent electrophysiological studies have demonstrated that nicotinic agonists stimulate the release of gamma-aminobutyric acid (GABA) from rodent brain tissue.
Positive_regulation (stimulate) of Localization (release) of GABA in brain associated with gaba and agonist
3) Confidence 0.40 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9808692 Disease Relevance 0 Pain Relevance 0.51
In the absence of both Ca2+ and Mg2+, EGTA and also EDTA at 50 microM or higher concentrations induced a 2.5-5-fold stimulation of [3H]GABA release, similar to that produced by potassium depolarization, whereas only a slight effect, or no effect at all, was observed on the release of the other transmitters studied.
Positive_regulation (induced) of Localization (release) of GABA associated with gaba
4) Confidence 0.40 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6144725 Disease Relevance 0 Pain Relevance 0.38
This Na+ dependence does not seem to involve voltage-sensitive channels, since tetrodotoxin did not affect the GABA-releasing action of EGTA, whereas in parallel superfusion chambers it blocked over 80% the stimulation of GABA release by veratridine.
Positive_regulation (stimulation) of Localization (release) of GABA associated with tetrodotoxin, addiction and gaba
5) Confidence 0.40 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6144725 Disease Relevance 0 Pain Relevance 0.70
The GABAergic system is also present in postnatal mouse testis: GAD67, VGAT and several GABAA receptor subunits in postnatal mouse testis
Positive_regulation (present) of Localization (several) of GABAA in testis associated with gabaergic
6) Confidence 0.40 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.23 Pain Relevance 0.05
In addition, TTX blockade of sodium-dependent action potentials itself would have significantly reduced the spike-mediated release of GABA, glycine, glutamate, acetylcholine, and dopamine by amacrine and ganglion cells of the inner retina, reinforcing the negative findings with the pharmacological blockers specific to each of these transmitter systems.
Positive_regulation (mediated) of Localization (release) of GABA in retina associated with ganglion cysts, action potential, tetrodotoxin, dopamine, glutamate and gaba
7) Confidence 0.39 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.10 Pain Relevance 0.58
Electrical transmural stimulation of the isolated cat colon led to an increase in the Ca2+-dependent, tetrodotoxin-sensitive release of endogenous GABA. gamma-Aminobutyric acid increased the amplitude of rhythmic contractions of the circular muscle of the colon and also the release of acetylcholine, which was Ca2+-dependent and tetrodotoxin-sensitive.
Positive_regulation (increase) of Localization (release) of GABA in colon associated with tetrodotoxin and gaba
8) Confidence 0.39 Published 1987 Journal Gastroenterology Section Abstract Doc Link 3609661 Disease Relevance 0 Pain Relevance 0.49
Potassium-induced depolarization caused calcium-dependent release of GABA.
Positive_regulation (caused) of Localization (release) of GABA associated with gaba
9) Confidence 0.39 Published 1987 Journal Brain Res. Section Abstract Doc Link 3594247 Disease Relevance 0.19 Pain Relevance 0.33
Local infusion of NA through a cannula, which was implanted 2 mm away from the dialysis probe, gave rise to a marked increase in GABA release.
Positive_regulation (increase) of Localization (release) of GABA associated with gaba and noradrenaline
10) Confidence 0.39 Published 1994 Journal Neuroreport Section Abstract Doc Link 7865739 Disease Relevance 0 Pain Relevance 0.72
This NA-induced GABA release was suppressed by tetrodotoxin, a sodium channel blocker, which was perfused at the probe site.
Positive_regulation (induced) of Localization (release) of GABA associated with tetrodotoxin, gaba, sodium channel and noradrenaline
11) Confidence 0.39 Published 1994 Journal Neuroreport Section Abstract Doc Link 7865739 Disease Relevance 0 Pain Relevance 0.73
Potassium-induced depolarization caused a release of GABA in a calcium-dependent manner.
Positive_regulation (caused) of Localization (release) of GABA associated with gaba
12) Confidence 0.39 Published 1983 Journal Brain Res. Section Abstract Doc Link 6871712 Disease Relevance 0 Pain Relevance 0.36
The release of GABA was also induced by veratrine and blocked by tetrodotoxin.
Positive_regulation (induced) of Localization (release) of GABA associated with tetrodotoxin and gaba
13) Confidence 0.39 Published 1983 Journal Brain Res. Section Abstract Doc Link 6871712 Disease Relevance 0 Pain Relevance 0.37
Ca2+-dependent, K+-induced release of beta-alanine, gamma-aminobutyric acid (GABA), and glutamate was observed.
Positive_regulation (induced) of Localization (release) of GABA associated with glutamate and gaba
14) Confidence 0.39 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6123549 Disease Relevance 0 Pain Relevance 0.33
Thus according to the immunolocalization of GABAA-?
Positive_regulation (according) of Localization (immunolocalization) of GABAA
15) Confidence 0.35 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0 Pain Relevance 0.28
It is then suggested that this effect might depend on an indirect activation of GABAB receptors through release of GABA.
Spec (might) Positive_regulation (activation) of Localization (release) of GABA associated with gaba
16) Confidence 0.34 Published 1992 Journal Neuropharmacology Section Abstract Doc Link 1326728 Disease Relevance 0 Pain Relevance 0.78
Morphine tolerance has proven to be accompanied by alterations in the efficiency of many neuronal signals, as well as by an inversion of the noradrenergic signal response of cortical acetylcholine terminals and gamma-aminobutyric acid (GABA) neurons in vivo (decreased acetylcholine and increased GABA release in normal animals, vice versa in tolerant).
Positive_regulation (increased) of Localization (release) of GABA in neuronal associated with gaba, tolerance and morphine
17) Confidence 0.33 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1650828 Disease Relevance 0 Pain Relevance 0.56
In CeA neurons of WT mice, ethanol superfusion significantly augmented (by 39%) GABAA-IPSPs and decreased PPF (by 25%), suggesting increased presynaptic GABA release.
Positive_regulation (increased) of Localization (release) of GABA in neurons associated with gaba and amygdala
18) Confidence 0.33 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.40
Increased GABA release also could dampen glutamate inputs either by shunting (increase in the membrane conductance) or by activation of GABAB receptors located on corticostriatal terminals.
Positive_regulation (Increased) of Localization (release) of GABA associated with glutamate and gaba
19) Confidence 0.31 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.16 Pain Relevance 0.23
On the other hand, glutamate also activates presynaptic NMDA receptors, which induce an increase in presynaptic GABA release.
Positive_regulation (increase) of Localization (release) of GABA associated with gaba, glutamate and nmda receptor
20) Confidence 0.29 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.10 Pain Relevance 0.78

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